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Biomedical subjects

A Storm-Mathisen

Publications and source records attributed to A Storm-Mathisen.

6 recordsLinked to original sources
PubMed1994

Conduct disorder patients 20 years later: a personal follow-up study.

As a part of a larger study, 75 consecutive patients with conduct disorder (48% men, median age 15, range: 6-19 years) were followed up after 18-21 years (mean: 19) with a clinical interview using DSM-III criteria. At follow-up, 47% had no Axis I disorder, 24% an anxiety disorder, 25% a substance abuse disorder and only one a psychotic disorder. Thirty-three percent fulfilled the criteria of an antisocial personality disorder. An additional anxiety disorder at the time of the primary examination was a strong predictor of a poor outcome, as was also criminal offences. The study shows the severe prognosis of conduct disorder and the importance of this disorder as an antecedent to substance abuse. However, since nearly half of these patients developed into a healthy state during the 20-year follow-up period, work should be continued to develop better treatment for these patients.

Adolescent↗
PubMed1992

[Myasthenia gravis].

Myasthenia gravis, first described in 1672 by Sir Thomas Willis and named by Jolly in 1895, is clinically characterized by muscular weakness relieved by rest. The incidence rate is about 4/million/year, the prevalence in Norway is about 100/million. Anticholinesterase drugs, introduced by Mary Walker in 1934, are still the primary therapeutics. Since about 1960 the disease has been recognized as autoimmune. Circulating antibodies to the acetylcholine receptor of the neuromuscular synapse are detectable in greater than or equal to 85% of the patients. Hence thymectomy, plasmapheresis and immunosuppressant drugs are useful. The thymus is recognizably pathological in 75-80% of the cases. The thymic hormone thymopoietin stimulates thymocytes and T-cells, and directly blocks the acetylcholine receptor.

Animals↗
PubMed1984

Epidemiology of myasthenia gravis in Norway.

The number of patients with myasthenia gravis diagnosed and registered in Norway from 1912-1981 has been collected, representing essentially all diagnosed cases during these 70 years. Until 1948, Oslo University Hospital, the National Hospital, had the only neurological department. in Norway. Since then, neurological departments have been established throughout our country. All these departments and all practising neurologists in Norway responded to the appeal for the necessary information on their diagnosed patients up to the end of 1981. The majority of the results are based on the period 1951-1981. The National Bureau of Statistics has registered the deaths of myasthenia gravis cases since 1951, and since 1956 where it has constituted an underlying or contributory cause. The incidence rate by diagnosis per million population 1951-1981 is 2.6 for males, 5.3 for females and 4 for both sexes. The prevalence per million population is 52 for males, 127 for females and 90 for both sexes. The mortality in males is 144% and in females 155% of the mortality in the population. The excess mortality is much greater in patients below 60 years of age, especially in females where a value of 483% if found.

Adolescent↗