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Biomedical subjects

A Stragier

Publications and source records attributed to A Stragier.

At least 19 recordsLinked to original sources
PubMed2005

Ultraviolet irradiation to preserve high reverse osmosis water quality.

AIMS: The use of ultrapure dialysate decreases hemodialysis patients' morbidity. Bacterial and endotoxin content of reverse osmosis (RO) water is usually lowered or eliminated by a combination of bacterial filtration and regular disinfection of the distribution. Whether bacterial filtration may be replaced by UV irradiation is unknown. MATERIALS AND METHODS: One, and subsequently two UV lamps were inserted in a complex RO water distribution circuit, devoid of bacterial filters. RO water bacterial content was checked weekly between RO water distribution disinfections. RESULTS: With one UV lamp on the departure of the RO water circuit, bacterial results remained negative (< 1 cfu/ml) till the second week after disinfection. Disinfection of the circuit was required every four weeks to comply with the AAMI Guidelines (< 200 cfu/ml). Failure of the lamp was followed by bacterial growth (up to 500 cfu/ml), promptly aborted after replacement of the failed lamp. Subsequent addition of a second UV lamp on the return line of the water circuit kept bacteria < 1 cfu/ml for up to five weeks. Endotoxin levels remained < 0.125 EU. CONCLUSIONS: UV irradiation preserves a low RO water bacterial/endotoxin content in the distribution line and is not associated with a measurable endotoxin increase.

Disinfection↗
PubMed2003

Daily weight gain and protein catabolic rate are lower over the long interdialytic interval.

BACKGROUND: The interdialytic weight gain (IDWG) and protein catabolic rate (PCR), expressed per 24 hours (daily), are usually assumed to be stable over the week in chronic hemodialysis (HD) patients. METHODS: We studied different HD patient groups at different time points (study 1 in 1993: n = 48, study 2 in 1999: n = 16, study 3 in 2000: n = 112). Daily IDWG (calculated from post- and pre-dialysis body weight and interdialytic interval) and nPCR (calculated from kinetic modeling) were compared over short (2 days) and long (3 days) intervals. RESULTS: In all groups of HD patients studied, both daily IDWG and nPCR were significantly (p < 0.05) lower (IDWG by 7-15%, nPCR by 5-6%) over long than short interdialytic intervals. This difference was observed whether or not blood sampling was planned after the long interval. This suggests selfrestriction of dietary intake over the long interdialytic interval. CONCLUSIONS: Daily IDWG and nPCR are lower over the long interdialytic interval. Studies should thus define or even standardize the period of time over which IDWG and nPCR are calculated.

Adult↗
PubMed1999

[Craniopharyngioma: ophthalmological manifestations and prognosis after treatment].

The craniopharyngioma is a benign tumor located at least in part in the suprasellar cistern. The symptoms are determined not only by the position of the tumor but also by its size and the age of the patient. The goal of our study is to analyse retrospectively the manifestations of craniopharyngioma and their prognosis after treatment in function of the age.

Adolescent↗
PubMed1996

[Idiopathic epimacular membrane and vitreo-macular traction syndrome: vitrectomy functional results].

The retrospective study of 26 consecutive cases of idiopathic epimacular membrane and vitreomacular traction syndrome treated by vitrectomy with a mean follow-up of 19 months showed very good functional results. The visual acuity at the last visit improved by 2 lines or more when compared with the preoperative visual acuity in 77% of pseudophakic eyes and eyes with clear lens. The metamorphopsia disappeared or significantly diminished in half the cases. The main postoperative complication was the appearance or progression of nuclear sclerosis, which could mask the good functional results of vitrectomy.

Adult↗
PubMed1995

Rinsing time and disinfectant release of reused dialyzers: comparison of formaldehyde, hypochlorite, warexin, and renalin.

The influence of disinfecting agent (DA) type on the rinsing time of reused dialyzers and DA rebound release after rinsing is unknown. We compared 10 groups of five dialyzers each: cellulose acetate capillaries and AN69 plates disinfected with formaldehyde (F), polysulfone and cuprophane capillaries disinfected with 3.5% Renalin (R; Renal Systems, Minneapolis, MN), polysulfone capillaries and AN69 plates disinfected with 0.5% R, and AN69 capillaries and plates disinfected with Hypochlorite (H; Solvay, Brussels, Belgium) or Warexin (W; Guardian Chemical, Division of United Guardian Inc, Hauppage, NY), respectively. Formaldehyde, R, H, and W were detected by standard tests. The rinsing time required to reach undetectable levels of DA is shortest for H and W, intermediate for R 0.5% and 3.5%, and longest for F (F v R, H, and W; R v H and W; and H v W: P < 0.001). The rebound release 30 minutes after completion of rinsing is the highest for F (average 6 ppm), intermediate for R 0.5% and 3.5% (mean 1.4 ppm, P < 0.002 compared with F and mean 2.95 ppm, P < 0.05 compared with F, respectively), and low (< or = 1 ppm) for W and H (P < 0.001 compared with F and P < 0.01 compared with R 3.5% and 0.5%). We conclude that the dialyzer rinsing time needed to obtain undetectable levels of DA depends on the DA type. In addition, we demonstrate that like F, R is released from reused dialyzers after "adequate rinsing." The potential clinical consequences of this phenomenon require further investigation.

Acetic Acid↗
PubMed1992

Hazards with disinfecting agents in renal units!

As already described in the April 1991 issue of EDTNA/ERCA Journal (Volume XVII, No. 2), the specific characteristics of various disinfecting agents delineate their respective application areas. Obviously, in a renal unit one needs a large range of disinfecting agents as they are being used for cleaning and disinfection of: water treatment devices; water tanks and distribution systems; single patient units; patient vascular access sites; dialysis connection procedure; dialyser reuse; instruments; floors, etc.... We have been taught never to mix different disinfecting agents as this might reduce their efficiency. However, it had never been hitherto reported that this might be dangerous or even cause an explosion! In this paper, we describe in detail how we were confronted with such an explosion. We further report that similar hazards occurred in other units and present an overview of possible hazards with the most common disinfecting agents. Finally, we emphasize some preventive guidelines to be put forth in renal units.

Disinfectants↗