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Biomedical subjects

A Stuart

Publications and source records attributed to A Stuart.

90 records · Page 5Linked to original sources
PubMed1973

Amitriptyline in migraine prophylaxis. Changes in pattern of attacks during a controlled clinical trial.

A double-blind controlled clinical trial of crossover design was conducted in 26 volunteers suffering from migraine. Of 20 subjects who completed the trial, 16 had fewer attacks on amitriptyline than on placebo. Amitriptyline was found to have the greatest effect in reducing attacks with a short warning and in which no specific cause could be recognized. It had least effect in attacks with a long warning and recognized as due to fatigue. The drug was effective only in reducing those attacks with shorter duration and its effect was irrespective of severity. A dosage of between 10 and 60 mg, usually taken at night, was found to be adequate.

Adult↗
PubMedDate not supplied

Neonatal auditory brainstem responses recorded from four electrode montages.

Simultaneous auditory brainstem responses (ABRs) to click stimuli at 30 and 60 dB nHL were recorded from 16 full term neonates with four electrode arrays: vertical (Cz-Nape of neck), ipsilateral (Cz-Mi), contralateral (Cz-Mc), and horizontal (Mc-Mi). Results indicated that ABR waveforms were morphologically similar to those recorded in adults: Waves I, III, and V were clearly identifiable and of the same polarity in 15 of 16 subjects 60 dB nHL and Wave V was clearly identifiable in 14 of 16 subjects at 30 dB nHL. Although ABR waves were identified in most cases, waveforms expression was variable with different electrode recording montages. It is suggested that if a clinician must choose one montage array for recording neonatal ABRs at high intensity levels for neurodiagnostic evaluations, the ipsilateral recording array is indicated since it displays the highest expression of wave components. For screening applications or threshold searching at lower stimulus levels, however, either the ipsilateral or vertical montage would be justified. Further, caution should be employed when interpreting ABR results in neonates recorded with unconventional montages due to the variable expression of wave components.

Electrodes↗
PubMedDate not supplied

Gender effects in auditory brainstem responses to air- and bone-conducted clicks in neonates.

UNLABELLED: Examinations of gender differences in auditory brainstem response (ABR) wave V latencies and thresholds to air- and bone-conducted clicks were undertaken with neonates. Two hundred and two full-term neonates participated (i.e., 103 males and 99 females). Wave V latency measures for air- and bone-conducted click stimuli of 30, 45, and 60 dB nHL and 15 and 30 dB nHL, respectively, and thresholds to air- and bone-conducted clicks were determined. Female newborns displayed statistically significant shorter wave V latencies than male newborns for air-conducted click stimuli (i.e., approximately 0.2-0.3 ms; P=.0016). There were no significant gender differences in wave V latencies to bone-conducted click stimuli (P=.11). With respect to ABR thresholds, no statistically significant differences were observed for either air-conducted clicks (P=.054) or bone-conducted clicks (P=.18). EDUCATIONAL OBJECTIVES: As a result of this activity, the participant will be able to (1) describe gender differences in ABR wave V latencies and thresholds to air- and bone-conducted clicks with neonates and (2) summarize possible explanations for observed gender differences in ABR wave V latencies and thresholds to air- and bone-conducted clicks with neonates.

Auditory Threshold↗
PubMedDate not supplied

Unilateral auditory temporal resolution deficit: a case study.

An adult with a unilateral precipitous severe high-frequency hearing loss displayed a selective auditory temporal resolution deficit in the poorer ear, despite excellent word recognition ability in quiet bilaterally. Word recognition performance was inferior in interrupted noise, reverberation, and time-compression conditions when stimuli were presented to the hearing-impaired ear and compared with performance for stimuli presented to the normal-hearing ear or that of normal-hearing listeners. It was suggested that a restricted listening bandwidth was responsible for the performance decrement on the tasks involving temporal resolution. This case illustrates the importance of employing temporal resolution tasks in an audiologic test battery. Such assessment tools may reveal deficits that otherwise may go unnoticed in light of excellent word recognition in quiet.

Adult↗
PubMedDate not supplied

Distortion product otoacoustic emissions in normal-hearing children with homozygous sickle cell disease.

The purpose of this study was to investigate distortion product otoacoustic emissions (DPOAEs) in young normal-hearing children with sickle cell disease (SCD). It was hypothesized that the prevalence of DPOAEs and response amplitudes would be lower than those in children with normal hemoglobin due to suspected compromised cochlear function as a result of vaso-occlusive events characteristic of SCD. Twenty African-American children with SCD and 15 African-American children with normal hemoglobin participated. Distortion product OAEs were evoked by 13 primary tone pairs with f2 frequencies ranging from 1000 to 4500 Hz. The primary tones were presented at L1 and L2 levels of 70 and 60 dB SPL (high) and 50 and 40 dB SPL (low), respectively. The findings of this study were completely unexpected and contrary to our original hypotheses. The likelihood of detecting a DPOAE response was not related to the clinical status of the children. Distortion product OAE amplitudes were significantly larger for children with SCD (p =.01).

Adolescent↗
PubMedDate not supplied

Effects of alterations in auditory feedback and speech rate on stuttering frequency.

This study investigated the effects of altered auditory feedback on stuttering frequency during speech production at two different speech rates, Nine stutterers, who exhibited at least 5% dysfluency during a reading task, served as subjects. They read eight different passages (each 300 syllables in length) while receiving four conditions of auditory feedback: nonaltered, masking, delayed, and frequency altered. For each auditory feedback condition, subjects read at both a normal and a fast rate. Results indicated that stuttering frequency was significantly decreased during conditions of delayed and frequency altered auditory feedback at both speech rates (p < 0.05). These findings refute the notion that a slowed speech rate is necessary for fluency enhancement under conditions of altered auditory feedback. Considering previous research and the results of this study, it is proposed that there may be two interdependent factors that are responsible for fluency enhancement: alteration of auditory feedback and modification of speech production.

Adolescent↗
PubMedDate not supplied

Possible neuronal refractory or recovery artifacts associated with recording the mismatch negativity response.

The mismatch negativity (MMN) is an event-related potential that involves a negative voltage shift of baseline electroencephalographic (EEG) activity in the approximate latency window of the N1 and P2 cortical potentials in response to new or novel sounds. The MMN is present at birth and has been hypothesized to serve as an automatic preconscious detector of changes in the auditory environment. Research paradigms used to extract the MMN response from EEG activity have a potential problem related to neuronal refractoriness or recovery. Both N1 and P2 are known to increase in amplitude with longer interstimulus intervals (ISIs). The MMN extraction procedures involve mathematical subtraction of waveforms elicited by standard sounds (with short ISIs) from those recorded to rare deviant sounds (with longer ISIs). Any ISI-dependent amplitude changes in N1 and/or P2 could therefore alter the morphology of the resulting difference wave and lead to misinterpretation of the nature of the underlying MMN generators. We tested 12 young females and found that the MMN can be influenced by ISI-dependent refractory effects that may modify the waveform morphology. This has important clinical implications since the MMN is being investigated as an assessment tool.

Adult↗