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Biomedical subjects

A Stumpf

Publications and source records attributed to A Stumpf.

6 recordsLinked to original sources
PubMed1999

Donor/Acceptor Metallocenes: A New Structure Principle in Catalyst Design.

Suitable as highly effective polymerization catalysts is the new class of donor/acceptor metallocenes in which the rotation of the two pi ligands is restricted through the formation of a dative D(+)-->A(-) bond (see picture). Specifically optimized substitution patterns yield excellent properties for the synthesis of high-melting, highly crystalline thermoplastic materials, amorphous thermoplastic materials with high glass transition temperatures as well as polyolefin elastomers with low glass T(g).

Journal Article↗
PubMed1997

Incidental appendix carcinoid. Value of somatostatin receptor imaging.

PURPOSE: Somatostatin receptor scintigraphy is used to diagnose carcinoid of the gastrointestinal tract. Its sensitivity ranges from approximately 75%-100%. Therefore, it was hypothesized that it can be used in the postsurgical follow-up to detect residual carcinoid, recurrence, and metastatic disease. RESULTS: This article is concerned with the findings of somatostatin receptor imaging performed on a 12-year-old girl 8 weeks after appendectomy. Histologic examination showed an incidental appendix carcinoid. Somatostatin receptor scintigraphy performed for detection of lymph node metastatic spread of the carcinoid showed focal tracer accumulation at the former operative site; subsequently, a right hemicolectomy was performed. However, histologic examination of the surgical tissue showed no evidence for carcinoid. CONCLUSION: It is concluded that there are some potential pitfalls for somatostatin receptor imaging at least soon after surgery. Therefore, it should not be used to aid in reoperation.

Appendiceal Neoplasms↗
PubMed1993

HTLV-I-related retroviral markers in Hungarian patients with mycosis fungoides.

Cell and serum samples from 7 Hungarian patients with mycosis fungoides were examined for the presence of HTLV-I-related DNA sequences and antibodies recognizing HTLV-I antigens. DNA sequences distantly related to the proviral DNA of HTLV-I were shown by Southern blot hybridization in 3 patients. Serum samples from these patients contained antibodies reactive with the internal core polypeptides of HTLV-I and HTLV-II, but not with the env gene encoded type-specific HTLV antigens. Restriction enzyme analysis with EcoRI, PstI, BamHI and SacI revealed structural similarity of the provirus(es) integrated in the DNA of mycosis fungoides cells to HTLV-I but not to HTLV-II. Data suggest that these proviruses and HTLV-I are similar to each other along gag and pol regions.

DNA, Viral↗
PubMed1977

Obtaining, evaluation and clinical application of antileukemic antilymphocyte globulin (ALLG) in the treatment of chronic lymphatic leukemia.

Antileukemic antilymphocyte globulin (ALLG) was obtained by immunizing horses with peripheral blood lymphocytes from patients suffering from chronic lymphatic leukemia. After absorbing the serum with erythrocytes, globulins were precipitated from the serum with ammonium sulfate. ALLG preparations were sterile, nontoxic and nonpyrogenic and contained no antibodies against basement membranes or antierythrocytic or antiplatelet antibodies. Nine patients with chronic lymphatic leukemia were treated with the globulin. Methods for selecting patients for treatment with ALLG and for controlled therapy were elaborated. Clinical and hematologic observation in the patients were reported. The high therapeutic efficacy of ALLG with high cytotoxic titer was emphasized. Beneficial hematologic and therapeutic effects were obtained in six patients. Attention was drawn to the efficiency of the combined therapy with ALLG, cytostatics and adrenal steroids.

Animals↗