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Biomedical subjects

A Susta

Publications and source records attributed to A Susta.

At least 37 records · Page 2Linked to original sources
PubMed1979

Kinetoplast test for the detection of antibodies against double-stranded deoxyribonucleic acid in patients with rheumatic diseases.

The differential diagnosis in rheumatology is frequently considerably facilitated or rendered possible by immunological methods. Evidence of antibodies against double-stranded deoxyribonucleic acid (ds-DNA) in systemic lupus erythematosus (SLE) is considered a conclusive confirmation of the diagnosis and moreover a useful criterion of the activity of the process. The authors developed an immunofluorescent method where as substrate the kinetoplast of the protozoon Trypanosoma danilewskyi containing pure ds-DNA not bound to histones is used. A total of 164 titrations of these antibodies were made in 113 patients with various diagnoses. The results indicate that anti-ds-DNA antibodies are present only in patients with SLE and that the titres correspond to the activity of the disease. The method is suited for routine use, the substrate being commercially available and of standard quality.

Adult↗
PubMed1978

Experience with high doses of ibuprofen in the long-term treatment of rheumatoid arthritis.

Ibuprofen (Brufen) is a non-steroidal anti-inflammatory drug well-established in the symptomatic treatment of rheumatoid arthritis. In view of its exceptionally good tolerance it has become fashionable to prescribe increasingly large doses for severe cases or in those patients unable to tolerate other anti-rheumatic compounds. This study illustrates the sustained therapeutic benefit and almost complete lack of toxicity in fify-nine rheumatoid patients treated with up to 1,600 mg ibuprofen daily over six months. Significant improvement occurred in all clinical parameters and gastro-intestinal upset leading to discontinuance of therapy was reported in just two patients. There were no abnormalities in any of the biochemical tests performed.

Arthritis, Rheumatoid↗