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A T Chamberlain

Publications and source records attributed to A T Chamberlain.

25 records · Page 2Linked to original sources
PubMed1982

Low lead levels in pagetoid bone.

The hypothesis that accumulation of trace elements in bone is an etiologic influence in Paget's disease was investigated by comparing the trace element content of pagetoid and normal bone. An initial analysis of iliac bone samples obtained at autopsy from 11 cases and 11 age- and sex-matched controls was carried out using emission spectrometry. Of the 12 elements present in detectable amounts, only lead showed large differences in concentration between diseased and normal bone. Mean lead levels were lower in diseased bone, both in comparison with bone from the controls and in comparison with normal bone from the cases. A second analysis, using atomic absorption spectrometry, was carried out on an additional 10 case/control pairs together with the original 11 pairs. This analysis was restricted to lead, barium, and strontium. Again, mean lead levels were lower in diseased bone. This difference was shown in both case/control groups. When results for the two groups were combined, mean levels of barium were also lower in diseased bone. Mean lead levels in normal bone from cases were lower than those in normal bone from their matched controls, suggesting an abnormality of lead distribution within the skeleton which is not confined to diseased bone.

Aged↗
PubMed1981

The anatomic distribution of osteitis deformans.

Previous observations on the anatomic distribution of Paget's disease of bone are substantiated by a study of an additional 639 patients and by comparison with radionucleide bone imaging. The main anatomic features are a preference for the lower rather than the upper limb girdle, a spinal distribution similar to that seen in vertebral spondylosis, and a tendency to right-sided involvement. Bone stress is a possible explanation of the skeletal distribution, and may therefore be significant in the pathogenesis of the disease.

England↗
PubMed1980

Paget's disease of bone: the Lancashire focus.

The radiological prevalence of Paget's disease of bone has been studied in 31 towns in Britain. A remarkably localised area of high prevalence has been shown in Lancashire. Although environmental influences seem dominant in the aetiology of the disease, no hypothesis about the environmental cause of the Lancashire focus can be advanced.

Aged↗
PubMedDate not supplied

Osteochondroma in a British neolithic skeleton.

The skeletal remains of past populations provide an important source of information on the natural history of disease. Relatively few cases of bone tumours have been reported in archaeological material. This paper describes one of the oldest occurrences of osteochondroma to have been identified in a human skeleton.

Adolescent↗