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Biomedical subjects

A T Jaffe

Publications and source records attributed to A T Jaffe.

4 recordsLinked to original sources

An alternate approach for harvesting Mohs specimens with a flexible scalpel.

BACKGROUND: Mohs micrographic surgery is a highly successful technique for removing skin cancers while conserving normal tissue. However, conservation of the deep margins can often be difficult to achieve when using a standard scalpel. An inability to conserve normal tissue at the deep margins can greatly impact the complexity of repair, duration of surgery, aesthetic result, and patient morbidity. OBJECTIVE: To find an alternative method of obtaining Mohs specimens that offers greater control of the depth of incision when compared to the standard scalpel. METHODS: We utilized a flexible scalpel to obtain Mohs levels on patients with superficial cutaneous malignancies in anatomic locations where careful conservation of the deep margins would allow for less extensive repair. RESULTS: For those patients who had tumor-free margins after one level of Mohs surgery, the shallower defects achieved with the flexible scalpel allowed for excellent cosmetic outcomes and decreased patient operative time and morbidity. CONCLUSION: The flexible scalpel is both effective and efficient in obtaining thin Mohs specimens when conservation of the deep margin is of utmost importance.

Humans↗

Epidermal maturation arrest.

BACKGROUND: Cutaneous wound repair involves a complex and temporal integration of cytokines, formed blood components, extracellular matrix, and parenchymal cells. The normal healing process can be impeded at any step along its path by a variety of factors. OBJECTIVE: We present four cases of abnormal wound repair in patients whose defects were left to heal by second intention following Mohs micrographic surgery. In particular, these patients experienced an unusual delay in healing with an apparent arrest of epidermal maturation. RESULTS: Each appeared to respond to a topical steroid and/or ibuprofen. The intent of this therapy was to inhibit products of the arachadonic acid cascade or other cytokines that may have been hindering normal epidermal differentiation. CONCLUSION: We present four case reports, a brief review of epidermal reconstitution in wounds, and a possible explanation for why our therapy may have hastened wound repair in our patients.

Adult↗