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Biomedical subjects

A T Teichmann

Publications and source records attributed to A T Teichmann.

At least 37 records · Page 2Linked to original sources
PubMed1988

Lipid metabolic changes during hormonal treatment of endometriosis.

Three groups of patients with pelvic endometriosis were treated with medroxyprogesterone acetate (MPA) 50 mg/day (n = 10), lynestrenol (LYN) 10 mg/day (n = 25) and danazol (DAN) 600 mg/day (n = 25) respectively. Total cholesterol, triglycerides, alpha-lipoprotein, prebetalipoprotein, beta-lipoprotein cholesterol, high-density (HDL) and low-density (LDL) lipoprotein and apolipoprotein A1 and B concentrations were determined before treatment and after 3 and 6 mth of therapy. Whereas lipid, lipoprotein and apolipoprotein levels did not change in the MPA group, the patients on LYN and in particular those on DNA showed marked changes in lipoportein patterns. Alpha-lipoprotein, HDL and apolipoprotein A1 levels fell, while beta-lipoprotein, LDL and apolipoprotein concentrations rose, these changes being statistically significant. No alterations were seen in the serum levels of cholesterol, triglycerides or prebetalipoprotein cholesterol. In view of a possible relationship between high LDL and low HDL levels and a risk of accelerated coronary arteriosclerosis in women it was concluded that progestogen-induced alterations in lipoprotein patterns should be avoided as far as long-term treatment is concerned and where additional risk factors are present.

Adult↗
PubMed1988

[Serum lipid and lipoprotein concentrations in pregnancy and at onset of labor in normal and complicated pregnancies caused by hypertensive gestosis and fetal growth retardation].

Cholesterol triglyceride and lipoprotein concentrations were determined in the sera of 220 pregnant women at different periods of their pregnancy. In 197 healthy pregnant women we found besides an increase in cholesterol level and in particular an increase in the beta-lipoprotein fractions, a marked increase in pre-beta-lipoprotein levels and more than twice as high triglyceride concentration in the course of the first to the third trimenon. Nothing abnormal was found on comparing the lipid and lipoprotein parameters of 13 pregnant women having hypertensive toxaemia, with those of healthy gravidae, with the exception of a marked increase in the pre-beta-lipoprotein levels in those patients who suffered from toxaemia. No connection was seen between infantile deficient development below the tenth percentile and the serum lipid and lipoprotein concentrations (n = 10) in the mother. Examinations carried out in 233 pregnant women and their children at the time of birth did not yield any connections between maternal and infantile protein patterns. All infants had definitely lower parameter concentrations than their mothers.

Adolescent↗
PubMed1987

Medroxyprogesterone acetate and lipid metabolic changes.

Lipid metabolic changes under oral treatment with medroxyprogesterone acetate (MPA) were investigated in four groups of patients: group I; 10 patients aged 25-45 (mean 38) years received 50 mg MPA daily for pelvic endometriosis. Group II; 21 patients aged 55-77 (mean 62) years received 200 mg MPA daily for surgically treated endometrial carcinoma stage I. Group III; 14 praemenopausal patients aged 37-52 (mean 47) years received 1000 mg MPA daily for metastasized breast cancer. Group IV; 27 post-menopausal patients aged 53-78 (mean 68) years were treated with 1000 mg MPA daily for metastatic breast cancer as well. A fifth group of initially 86 patients aged 40-86 (mean 63) years after surgery for endometrial carcinoma stage I served as untreated control for groups II and IV. Cholesterol and triglyceride concentrations were measured enzymatically lipoproteins were determined by quantitative electrophoresis and precipitation and apolipoproteins A1 and B were quantified by kinetic rate nephelometry. Whereas in patients of group I no changes of lipid and lipoprotein parameters were observed, daily oral doses of 200 mg MPA and more led to a marked fall in alpha-lipoprotein-, HDL-cholesterol and apolipoprotein A1 levels. beta-Lipoprotein-, LDL-cholesterol and apolipoprotein B concentrations rose significantly in Groups III and IV. The relevance of these findings in terms of athero-genicity is discussed.

Adult↗
PubMed1985

Effects of medrogestone and conjugated oestrogens on serum lipid and lipoprotein concentrations.

Twenty patients, aged 30-60 yr, who had undergone bilateral ovariectomy, were treated orally with 5 mg medrogestone (6,17-dimethylpregna-4,6-diene-3,20-dione) and 1.25 mg conjugated oestrogens per day, according to a constant dosage pattern during the cycle (22 + 6 days). The lipids and lipoproteins were determined twice before the start of therapy and 3, 6 and 12 mth thereafter. The lipids were quantified enzymatically and the lipoproteins by quantitative lipoprotein electrophoresis. Whilst cholesterol and triglyceride concentrations showed no detectable change, a slight but significant increase was seen in the high-density alphalipoprotein (HDL) cholesterol concentrations. The low-density beta-lipoprotein (LDL) cholesterol level showed a moderate fall. There was a resultant reduction in the beta/alpha-lipoprotein ratio. Accordingly, the apoprotein A1 concentrations were found to be elevated, while apoprotein B tended to fall to lower levels during therapy. When these changes are measured by the lipid metabolism risk criterion for the occurrence of coronary heart disease applicable to post-menopausal patients, the effects of the above-mentioned combination may be regarded as entirely favourable.

Adult↗
PubMed1985

[Changes in serum lipoproteins under hormonal therapy of breast carcinoma and other endocrine-dependent tumors].

The higher the low-density-lipoprotein cholesterol (beta lipoprotein) level, the greater the risk that coronary heart disease will develop, alpha-lipoprotein fractions (high-density-lipoproteins) are considered to be protective factors. Medroxyprogesterone acetate is responsible for characteristic changes of the lipoprotein patterns indicating enhanced coronary risks. Medroxyprogesterone acetate is applied in the therapy of breast, uterus and ovarian cancer. A statistically significant decrease was observed in alpha-lipoproteins whereas beta-lipoproteins increased without statistical significance. A similar reaction can be observed under the combination therapy of aminoglutethimide and medroxyprogesterone acetate, whereas the combination of cortisone and aminoglutethimide has a distinct influence on beta-lipoproteins but the alpha-lipoprotein level remains uninfluenced. According to these data the effect of an adjuvant application of these drugs must be carefully evaluated due to an increase of coronary risks.

Aminoglutethimide↗
PubMed1984

[Lipoprotein changes during hormonal treatment of endometriosis with lynestrenol and danazol].

The Lipoprotein profile of 24 patients with endometriosis was determined before, during and after the treatment with the two steroid hormones Lynestrenol (10 mg/day) and Danazol (600-800 mg/day). The total cholesterol triglycerides, beta-, prebeta-, and Alphalipo -protein bound to cholesterol were determined. Both hormones cause a marked lowering of the Alpha-Lp-cholesterin. In addition, the beta-LP-cholesterin was elevated and the beta-alpha-LP-ratio was elevated. In the dosage used by us, Lynestrenol showed less effect on the Lipoprotein profile. Danazol caused changed in the beta- and alpha-lipoprotein pattern of highly pathological atherogenic types. The total cholesterol was not influenced. Since women in the fertile age group will suffer a higher risk of arteriosclerosis from an elevation of the beta-LP-cholesterin, the treatment with Danazol calls for a sophisticated monitoring of the lipid metabolism and care in the indication for long term treatment with Danazol or with Lynestrenol.

Adult↗
PubMed1984

[Premature uterine contraction from the psychosomatic viewpoint. A critical literature review of methods].

Premature labor is often followed by premature delivery. This is to be prevented because of the increased perinatal mortality and morbidity. Etiology of premature uterine activity has not been elucidated up to now neither medically nor psycho-socio-somatically. There are many contradictory findings examining imminent premature labor with view to psychosomatics. In this review they are listed tabularly and investigated critically with regard to methodological structure. It is evident, that conflicting results are caused by disregard of fundamental principles of planning experiments and data analysis. The procedure should be thought over newly and exact research aspired including interdisciplinary knowledge.

Adaptation, Psychological↗
PubMed1984

[Usefulness of the S-S-G, a questionnaire for measuring attitude to pregnancy, sexuality and birth].

As a part of a larger research-project a questionnaire to measure attitudes towards pregnancy, sexuality and birth was used. The questionnaire, S-S-G, was developed by Lukesch and Lukesch. It is designed to measure attitudes which are believed to be very important for the processes of pregnancy, birth and eventually to the fetal development, as well. Our findings do not support the relevance and significance of this questionnaire. The further use of the S-S-G cannot be recommended because: 1. The standardization is not valid according to our and other random samples. 2. The authors' proofs of validity are not sufficient and cannot be replicated with the exception of one statement. 3. Other correlations postulated cannot be confirmed with our sample. 4. The questionnaire is both in substance and method insufficient. 5. The questionnaire is recommended by the authors for uses which have not been tested by them.

Abortion, Induced↗