AUTOMATIC ANALYSIS OF PHONOCARDIOGRAMS.
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Biomedical subjects
Publications and source records attributed to A TARANTA.
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Pepsin-digested rabbit antibody (5S) provoked reverse passive cutaneous anaphylaxis in the guinea pig, but was somewhat less effective, mole for mole, than the native antibody. Fixation of guinea pig complement by the pepsin-digested antibody could not be demonstrated either in vitro or in vivo. Splitting of the 5S fragment into two monovalent fragments (3.5S) markedly reduced the capacity to provoke reverse passive cutaneous anaphylaxis.
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Rabbit antibodies (7S) degraded by papain into univalent 3.5S fragments fail to fix complement when they combine, but do not precipitate, with the homologous antigens. Divalent 5S fragments obtained by pepsin digestion (composed of fragment I linked to II, but lacking fragment III) also fail to fix complement although they precipitate with homologous antigens. The amount of specific precipitate formed by the 5S antibody fragment is not increased by exposure to complement
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