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Biomedical subjects

A TASMAN

Publications and source records attributed to A TASMAN.

At least 19 recordsLinked to original sources
PubMed1962

Immunization against tetanus of patients given injections of antitetanus serum.

The authors report on an investigation conducted in the Netherlands into the best method of active immunization of patients treated with antitetanus serum; the active immunization is conferred by two intramuscular injections of tetanus phosphate toxoid at one month's interval.Trials were carried out on a total of 153 patients to determine the relative value of three treatment schemes: (a) the first vaccination and the serum injection given simultaneously but in different sites, (b) the first vaccination and the serum given in a single mixed inoculation, and (c) the first vaccination given one month after the serum injection. The results show that with simultaneous administration of vaccine and serum in different sites the patient acquires a reasonable antitoxin titre more rapidly than with either of the other schemes. Not only is he quickly protected, but he also receives his first vaccination at a psychologically opportune moment-when he is being treated for an accident.The authors lay special stress on the value of booster injections and discuss the difference in immune response between those under and over 20 years of age.

Humans↗
PubMed1959

Consistency in potency assay of tetanus toxoid in mice.

The use of mice for the assay of tetanus toxoids would offer considerable advantages over the use of guinea-pigs, but mice cannot readily be immunized with the fluid tetanus toxoid at present designated as the International Standard. This study shows, however, that the mouse is a very suitable laboratory animal for the comparison of adsorbed tetanus toxoids, and that an AlPO(4)-adsorbed vaccine, which is stable at 4 degrees C, is a satisfactory reference preparation. The log-dose-response lines of toxoids adsorbed on different quantities of AlPO(4) and on various quantities of another adsorbent ran parallel to those of the reference vaccine. The 95% confidence limits for the potencies of tetanus vaccines, diphtheria-tetanus vaccines, and diphtheria-pertussis-tetanus vaccines, determined by assay against the reference vaccine in mice, showed a high degree of reproducibility of the results.

Animals↗
PubMed1957

Problems concerning the prophylaxis, pathogenesis and therapy of diphtheria.

The first part of this article on the prophylaxis, pathogenesis and therapy of diphtheria is devoted to an epidemiological survey of the results achieved with active immunization against the disease. From these results it can be concluded that active immunization has been largely responsible for the decrease in the morbidity and mortality rates which has taken place in the past half-century.In the second part, the authors deal at length with problems relating to the pathogenesis and therapy of the disease, discussing such subjects as the different types of diphtheria bacteria, the significance of non-virulent strains, the action of bacteriophages, the plurality of diphtheria toxin, the use of antibacterial sera, and the importance of the "avidity" of antitoxic sera.Finally, taking into consideration the data presented in the preceding parts, the authors put forward their views as to the cause of diphtheria, the measures which should be taken to control it, and the most satisfactory form of therapy.

Anti-Bacterial Agents↗
PubMed1954

Results obtained with diphtheria phosphate toxoid.

An investigation was recently carried out in the Netherlands to determine the value of Diphtheria Phosphate Toxoid-a highly purified aluminium-phosphate-adsorbed toxoid prepared at the National Institute of Public Health, Utrecht-for active immunization against diphtheria. The authors describe the procedure followed in this study, in which 4,272 persons of both sexes and of ages ranging from under 1 year to 70 years were inoculated with the vaccine, and give a detailed analysis of the results obtained.

Aluminum Compounds↗