Biomedical subjects
Publications and source records attributed to A Taaffe.
Seventy-eight cases of pilomatricoma are reported. The unexpected findings are new lesions occurring in middle and old age; the lack of association with other diseases; and the large number of lesions located deep in the skin. As contemporary knowledge of the nature of this disorder is advancing, it is suggested that the eponymous title be abandoned.
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Four patients are described who developed granulomatous reactions in the red portions of their tattoos. Histopathological and immunofluorescence studies showed features of lichen planus. Mercury was identified in only one patient's lesion, and hypersensitivity to mercury was shown by patch testing in one other patient. Tattooing may provide a localised antigenic challenge resulting in spontaneously occurring lichen planus.
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The clinical features, diagnosis management, aetiology and inheritance of angiokeratoma corporis diffusum (Fabry's disease) are discussed and the literature reviewed. The treatment and knowledge generally of this rare condition have not greatly improved in 75 years.
The mechanisms, clinical features and management of the various forms of urticaria are discussed. The importance of histamine receptors, complement and the kinin cascade are reviewed.
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