New fluorescence probes for drug-albumin interaction studies.
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Binding Sites↗
Biomedical subjects
A Takadate
Publications and source records attributed to A Takadate.
[Electronic properties of N-heteroaromatics. LVIII. Electronic interaction of some biologically active aminoacridines and deoxyribonucleic acid (DNA): ultraviolet hypochromism (author's transl)].
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Acridines↗
[Synthesis of 3-aminoisocarbostyril derivatives and their reactions with primary amines (author's transl)].
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Amines↗
[Synthesis of 1H,5H-s-triazolo[1,5-b]isoquinolin-5-ones and 6H-as-triazino[2,3-b]isoquinolin-6-ones by cyclization of 2,3-diaminoisocarbostyril derivatives (author's transl)].
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Acetone↗
Fluorescence quenching of DNA by carcinogenic quinolines.
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Animals↗
Promotion by DNA of the photoinduced radical production from 4-nitroquinoline 1-oxide in aqueous medium at 77 degrees K and its mechanism.
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Carcinogens↗
[Electronic properties of N-heteroaromatics. 32. H-nuclear magnetic resonance spectra of chloro- and fluoro-substituted pyrimidine derivatives: relationship between chemical shifts of ring and substituent protons and electron densities].
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Chlorine↗
Electronic properties of N-heteroaromatics. XL. A nuclear magnetic resonance study of the interaction of 4-nitroquinoline 1-oxide with deoxyribonucleosides.
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Deoxyribonucleases↗
Charge transfer in the molecular interaction of 4-nitroquinoline 1-oxide and related carcinogens with DNA and deoxyribonucleosides.
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Animals↗
[Electronic properties of N-heteroaromatics. XXVII. 19F nuclear mangetic resonance spectra of 2, 4, and 6-fluorosubstituted pyrimidine derivatives].
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Chemical Phenomena↗
[Studies on heterocyclic compounds. 3. Ring closure reaction of 4,5-diamino-6-substituted-aminopyrimidines].
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Chemical Phenomena↗
Urinary metabolites of 2,6-diisopropylnaphthalene in rats.
Metabolism of 2,6-diisopropylnaphthalene (2,6-DIPN) in rats was found to proceed exclusively through oxidation of the isopropyl chain of the molecule. Five unconjugated metabolites were isolated from the urine and identified: 2,6-naphthalenedi(2-propan)-2-ol, 2-[6-(1-hydroxy-1-methyl)ethylnaphthalen-2-yl]-2-propionic acid, 2,6-naphthalenedi-2-propionic acid, 2-[6-(1-hydroxy-1-methyl)ethylnaphthalen-2-yl]-2-hydroxypropionic acid, and 2-[6-(1-hydroxy-1-methyl)ethylnaphthalen-2-yl]-1,2-propanediol, together with a small amount of the unchanged compound. The identification of these metabolites was made by means of mass, infrared, and nuclear magnetic resonance spectrometry. The presence of glucuronides of five metabolites described above was also suggested by thin-layer and gas-liquid chromatography of the extract that was obtained after hydrolysis by beta-glucuronidase. In addition, the quantitative determination of metabolites indicated that these five were the major urinary metabolites of 2,6-DIPN, and that the total urinary excretion of these metabolites in 24 hr after administration was about 23% of the dose.
Animals↗