Recent advances in the diagnosis and in the prevention of rheumatic fever.
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Biomedical subjects
Publications and source records attributed to A Taranta.
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In children and adolescents who each had at least one previous episode of rheumatic fever and who were not maintaining effective anti-streptococcal prophylaxis, the attack rates of subsequent streptococcal infections declined with advancing age, but were unaffected by gender, cardiac status, or multiplicity of antecedent rheumatic episodes. The rate of rheumatic recurrence per streptococcal infection fell with advancing age, but rose with increasing amounts of cardiac damage and with multiplicity of previous rheumatic attacks. The results suggest that the underlying clinical features of the host have a greater effect on the rheumatogenicity of an acquired streptococcal infection than on the ability to avoid the infection.
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Staphylococcus aureus strain DA352, grown in a diffusate of Todd-Hewitt broth, produced two extracellular nondialyzable lymphocyte mitogens having isoelectric points of 5.5 to 5.7 and 8.6 to 9.0. The mitogens were separable from one another by isoelectric focusing and could be isolated free of detectable amounts of other staphylococcal products by ethanol precipitation followed by isoelectric focusing. Dose-response curves with both mitogens showed a maximum per cent transformation in the range (90%+) obtained with phytohemagglutinin (PHA), a decrease of transformation with excess mitogen, and, with decreasing concentrations, a slope somewhat less steep than that obtained with PHA. Incubation with undigested or pepsin-digested pooled human gamma globulin enhanced the activity of the basic mitogen.
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