PubMed Health⌕ Search

Biomedical subjects

A Tartara

Publications and source records attributed to A Tartara.

17 recordsLinked to original sources
PubMed1979

[Long-term treatment with lithium salts and cerebral electric activity. Experimental research].

An eeg study was carried out in rabbits to investigate the neurophysiological effects of chronic lithium clorure treatment. The Monnier and Gangloff's stereotaxic method was used for recording cortical and deep structure activity. Lithium clorure was administered i.p. at doses of 20 mg/Kg/die for 15-22 days (mean plasmatic levels: 0.04 mEq/l). The eeg changes consisted in synchronization of the cortical activity, slowing of the deep structure activity and increase of CAD spiking. The most interesting finding was the appearance of peculiar periodic spikes in the CAD and subcortical structures. A similar pattern has been previously described by us in rabbits treated with repeated ECT.

Animals↗
PubMed1979

Antagonism between dopaminergic and neuroleptic drugs. I. Acute administration.

In this paper we report our results concerning the antagonism between dopaminergic (bromocriptine, apomorphine, piribedil) and neuroleptic (haloperidol, chlorpromazine, reserpine, clotiapine) drugs on the eeg and behaviour of rabbits. The Monnier and Gangloff stereotaxic method was used in order to record cortical and deep structures. The use of neurophysiologic methods also enabled us to verify the magnitude and modes of the antagonism between the two types of drugs. Particularly, the dissociation between eeg and behavioural effects of this antagonism is discussed; this fact seems to confirm the hypothesis that dopaminergic drugs have a double point of attack in the CNS.

Animals↗
PubMed1979

Antagonism between dopaminergic and neuroleptic drugs. II. Chronic administration.

In this work the eeg and behavioural effects obtained after the administration of dopaminergic drugs (bromocriptine, apomorphine, piribedil) in rabbits chronically pretreated with haloperidol, chlorpromazine, clotiapine, are shown. The Monnier and Gangloff stereotaxic method was used. The aim of the study was to verify receptor supersensitivity by neurophysiologic methods. The neurophysiologic pattern of receptor supersensitivity induced by long-lasting treatment with neuroleptic drugs and its peculiarity are discussed.

Animals↗
PubMed1979

Dopamine-agonist drugs and cerebral electrical activity in the rabbit.

The eeg changes induced by acute administration in rabbits of dopamine-agonist drugs (bromocriptine, apomorphine, piribedil) were studied. We examined the spontaneous electric activity of cortex and deep structures, the electric excitability thresholds and the action of these drugs in "cerveau isolé" rabbit. Eeg findings were correlated with behavioural reactions. The modes of action and the probable double point of attack of the drugs at the CNS are discussed.

Animals↗
PubMed1975

Two-dimensional immunoelectrophoresis: a new simplified method.

A new method of two-dimensional immunoelectrophoresis is described, in which fixed amounts of both antigen (total proteins) and antibody are employed. When applied to normal human sera, it results in the appearance of 15 peaks accounting for the commonest serum proteins with the only exception of alpha 1-acid glycoprotein. Transferrin, measured by Laurell's or Mancini's technique, is used as an internal standard. The height of the transferrin peak at 300 mg% is determined by a calibration curve. The heights of the various peaks are thus expressed as percentages of that of transferrin at 300 mg%. The method appears to be simple, rapid and antiserum-saving.

Adolescent↗