The effect of toyocamycin on cellular RNA synthesis.
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Animals↗
Biomedical subjects
A Tavitian
Publications and source records attributed to A Tavitian.
Selective inhibition of ribosomal RNA synthesis in mammalian cells.
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Animals↗
Preservation of the leukemogenic activity and elimination of contaminants during purification of Rauscher virus.
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Centrifugation↗
Estimation of the molecular weight of adenovirus 12 tumor CF antigen by rate-zonal centrifugation.
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Adenoviridae↗
Quantitative study of Rauscher virus inactivation by various physical and chemical agents.
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Centrifugation↗
[Characterization of the polysomes of mammalian cells cultivated in vitro].
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Animals↗
Study of oncogenic potentialities of human melanoma: identification of N-ras oncogene after DNA transfer and tumour induction.
The oncogenic potentialities of human melanoma cells derived from two different patients were studied using DNA-mediated gene transfer into NIH 3T3 cells followed by tumor induction into athymic nude nice. 64% of the mice injected subcutaneously with selected cells which had been co-transfected with human melanoma DNA and the selective marker NeoR developed tumors within 3-4 weeks, while up to 100% of those injected with cells transfected three days before with melanoma DNA developed tumors within 4-6 weeks. Southern blots analysis of the tumors indicated that almost all of them contained human sequences. Hybridization with different oncogene probes showed the presence of an human Eco RI N-ras-hybridizing fragment in the primary and secondary derived tumors, indicating that a transforming N-ras oncogene in human melanoma had been transferred to recipient cells and that transformed cells induced tumors in nude mice.
Animals↗