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Biomedical subjects

A Teddy Weiss

Publications and source records attributed to A Teddy Weiss.

8 recordsLinked to original sources
PubMed2006

ST-deviation patterns in recurrent myocardial infarctions.

Myocardial infarction (MI) may be classified as ST-elevation MI (STEMI) or non-STEMI (NSTEMI). We used the term "recurrent MI" (RMI) to denote repeat MI episodes in a particular patient in which a different coronary site is responsible for each episode. We investigated whether the type of RMI is more likely to be of the same type as the index MI or whether patients may have the 2 types of MI at random. The analysis included 305 patients who had >or=2 MI episodes. Acute MIs were classified as STEMI or NSTEMI. We attempted to include only MIs of native vessels, without the presence of extracardiac conditions that intensify myocardial ischemia. Most patients (76%) had repeat episodes of the same MI type, i.e., STEMI or NSTEMI. Recurrent STEMI occurred in 44% of patients, recurrent NSTEMI in 32%, and STEMI and NSTEMI in 24%. Thus, most patients with RMI episodes will have STEMIs or NSTEMIs but not the 2 types, suggesting a predilection of some patients to repeat episodes of occlusive thrombi and others to repeat episodes of nonocclusive thrombi.

Aged↗
PubMed2006

Comparison of cardiovascular risk of noncardiac surgery following coronary angioplasty with versus without stenting.

Previous studies have shown a high incidence of cardiovascular complications when noncardiac surgery (NCS) is performed after coronary stenting. No study has compared the outcomes of NCS after stenting compared with percutaneous transluminal coronary angioplasty (PTCA) alone. The records of all patients who underwent NCS within 3 months of percutaneous coronary intervention at our institution were reviewed for adverse clinical events with the end points of acute myocardial infarction, major bleeding, and death < or = 6 months after NCS. A total of 216 consecutive patients were included in the study. Of these, 122 (56%) underwent PTCA and 94 (44%) underwent stenting. A total of 26 patients (12%) died, 13 in the stent group (14%) and 13 in the PTCA group (11%), a nonsignificant difference. The incidence of acute myocardial infarction and major bleeding was 7% and 16% in the stent group and 6% and 13% in the PTCA group (p = NS), respectively. Significantly more events occurred in the 2 groups when NCS was performed within 2 weeks of percutaneous coronary intervention. In conclusion, our study has demonstrated high rates of perioperative morbidity and mortality after NCS in patients undergoing PTCA alone, as well as stenting. These findings support the current guidelines regarding the risk of NCS after stenting but suggest they be extended to PTCA as well.

Age Factors↗
PubMed2005

Tumor necrosis factor and interleukin-6 levels in hypertensive patients with and without left ventricular hypertrophy.

The objective of this prospective study was to examine the association between serum levels of TNF (tumor-necrosis factor) and IL-6 (interleukin-6) and left ventricular mass in hypertensive patients. Hypertensive patients currently receiving medical therapy were eligible. All subjects underwent echocardiography with measurements of left ventricular (LV) mass and ejection fraction (EF) and had serum levels of TNF and IL-6 measured by ELISA immunoassay. 35 subjects (20F, 15M; mean age 56.4 +/- 10.5 yrs) were studied. 19 patients (54%) had elevated LV mass. Of these patients, 6 (32%) had detectable serum TNF levels and 1 (7%) had detectable IL-6 levels, (p = NS). Hypertensive patients with elevated LV mass do not consistently exhibit elevated cytokine levels when compared to those with normal LV mass.

Aged↗
PubMed2005

Effects of external pressure on arteries distal to the cuff during sphygmomanometry.

The aim of this study was to examine the effect on distal arteries of external pressure, applied by upper arm sphygmomanometer cuff. Photoplethysmographic (PPG) signals were measured on the index fingers of 44 healthy male subjects, during the slow decrease of cuff air pressure. For each pulse the ratio of PPG amplitude to its baseline (AM/BL) and its time delay (deltaTD) relative to the contralateral hand were determined as a function of cuff pressure. At cuff pressures equal to systolic blood pressure, pulses reappeared with the pulse time delay in the cuffed arm significantly greater than in the noncuffed arm, with (deltaTD) (mean +/- SD) 150 +/- 31 ms (p < 0.001). At cuff pressures equal to diastolic blood pressure (81 +/- 12 mmHg), deltaTD was 42 +/- 19 ms (p < 0.001), and at 50 mmHg, which is below diastolic blood pressure, (deltaTD) was still significantly positive at 6 +/- 9 ms (p < 0.001). AM/BL relative to its initial value rose at cuff pressures between systolic and diastolic blood pressure, then deceased to 0.6 +/- 0.41 (p < 0.001) at diastolic blood pressure and 0.54 +/- 0.24 (p < 0.001) at 50 mmHg. The changes in (deltaTD) and AM/BL can be interpreted as originating from changes in the compliance of conduit arteries and small arteries with cuff inflation and deflation.

Adolescent↗
PubMed2003

Characteristics, management and outcome of patients with prior coronary bypass surgery presenting with acute myocardial infarction.

We compared the characteristics, management and outcome of patients with or without prior coronary artery bypass graft surgery (CABG) presenting with AMI to any coronary care unit in Israel, from four national surveys performed during 1992-1998. Of 5,396 patients, 171 (3.2%) had prior CABG, 39 of whom received thrombolysis. Thrombolysis was administered less often in patients with prior CABG, but the utilization of coronary angiography was similar. Mortality rates were higher in patients with prior CABG, particularly among those given thrombolysis. The use of coronary angiography was a strong independent predictor of survival, but its utilization was similar in patients with or without prior CABG. Patients with prior CABG constitute a small minority among current AMI patients. They are sicker and their mortality is higher compared to patients without prior surgery, especially among those given thrombolysis. Coronary angiography is associated with improved outcome in these patients but is currently used to the same extent as in patients without prior surgery.

Angioplasty, Balloon, Coronary↗