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Biomedical subjects

A Tedeschi

Publications and source records attributed to A Tedeschi.

At least 145 records · Page 8Linked to original sources
PubMed1984

Plasma of normal, but not atopic persons reducing basophil degranulation induced by anti-IgE.

The response to anti-IgE serum of basophils from allergic and normal persons in the presence of whole plasma or as washed cells in Tyrode solution was examined to detect any inhibiting activity of human plasma. A factor reducing the potential of anti-IgE serum to degranulate basophils was present in plasma of normal but not of allergic persons. It is considered that this property of plasma could contribute to homeostatic control in immediate hypersensitivity.

Adult↗
PubMed1984

Conversion of longstanding atrial flutter to sinus rhythm and transient complete A-V block following oral administration of verapamil. Report of a case.

In a patient with ischaemic heart disease chronic atrial flutter reverted to sinus rhythm during treatment with oral Verapamil, given at dosage of 240 mg once a day in order to prevent spontaneous angina. Such an unexpected event was accompanied by a remarkable sinus node depression and by a transient complete a-v block, that gradually subsides leaving a slight permanent a-v conduction delay. Either a higher bioavailability of the drug or an extremely increased sensitivity of the receptors can explain such a marked electrophysiological effect at a moderate drug dosage.

Aged↗
PubMed1984

[Intolerance to rice: a food intolerance uncommon in children].

We report the first case, in our knowledge, of dietary intolerance only to the rice in childhood. Gastrointestinal symptoms and shock-like state in relation to the ingestion of ground rice were observed in a 5-month-old girl. At 34 months she was still clinically intolerant to this food.

Diarrhea, Infantile↗
PubMed1983

Clinical significance of specific IgE determination on nasal secretion.

The clinical use of RAST on the nasal secretions was investigated in seventeen atopic patients, with asthma or rhinitis, who had shown at a first diagnostic screening, some difficulties in the identification of the responsible allergen(s). The results of the skin tests, of the RAST on the serum and on the nasal secretions and of the specific provocation test (bronchial or nasal) were compared. In some cases the basophil degranulation test was performed. The results of the RAST on the nasal secretions were in perfect agreement with the provocation test. The skin tests and the RAST on the serum showed many discrepancies, particularly for Dermatophagoides, epidermal derivatives of cat and dog and moulds, and less frequently for Graminaceae and other pollens. It is concluded that RAST analysis on nasal secretions is useful in clinical diagnosis of allergy especially for Dermatophagoides, epidermal derivatives and moulds. Most false positive results were observed with the RAST on serum; in fifteen cases it was positive, while all the other tests, basophil degranulation test included, were negative. The data suggest that IgE may have a low affinity for basophil receptors.

Adolescent↗
PubMed1983

Effect of verapamil on allergen-induced asthma in patients with respiratory allergy.

Specific degranulation of mast cells and basophils depends upon transmembrane calcium flow. In the present studies the protective effect of the calcium-antagonist drug verapamil against allergen-induced asthma was assessed in eight atopic patients. The results of this study showed that verapamil, administered both orally or by aerosol, can prevent the specific bronchoconstriction.

Administration, Oral↗
PubMed1982

Basophil activation in idiopathic mixed cryoglobulinemia.

We studied basophil activation in patients affected by idiopathic mixed cryoglobulinemia in order to investigate the role of the basophil cell in the pathogenesis of the vasculitis typical of this disease. We selected 13 patients and we performed the in vitro basophil degranulation test with cryoprecipitate; in 5 cases the test was positive when it was performed in whole blood, while it was negative when it was performed with cells washed and resuspended in Tyrode's buffer. In 6 subjects it was not possible to perform the test because of the very low number of circulating basophil cells. Finally, in 2 subjects the in vitro basophil degranulation test with cryoprecipitate was negative; this result may be related to the very low levels of complement factors in the sera of these subjects. These findings suggest that the pathogenetic mechanism of vasculitis in idiopathic mixed cryoglobulinemia could be started by basophil activation.

Adult↗
PubMed1981

The relationship between metoclopramide and milk secretion in puerperium.

The Authors administered Metoclopramide to women in puerperium with poor lactation. An increased lactation and high serum prolactin levels were noted. The administration of this medicine did not provoke any variations in serum T3, T4 and TSh levels. thyroid screening of the treated mothers' babies resulted negative.

Adult↗
PubMed1980

Amniotic fluid reverse triiodothyronine in normal and high risk pregnancies.

The authors have dosed by radioimmunoassay the rT3 concentrations in the amniotic fluid of 12 normal pregnant women and of 25 women with high risk pregnancies at the same period of gestation. The average of the rT3 concentrations in the amniotic fluid of pregnant women affected by diabetes mellitus, EPH gestosis and with foetal growth, retardation, are not different from those found in the control group. In the patients affected by Rh isoimmunization, the rT3 levels are remarkably higher than those found in the control group. The rT3 highest levels found in the amniotic fluid of pregnant women affected by Rh isoimmunization could be due. 1) to a decreased transformation of rT3 in rT2 for an accentuated alteration of the sulphydryl groups: 2) to a need of blocking the pathway's conversion of T4 in T3 (hormone with great catabolic effect) in these foetuses already presenting an accentuated catabolism for the chronic hemolytic enemy and for the severe hepatic alterations.

Amniotic Fluid↗