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A Testa

Publications and source records attributed to A Testa.

At least 55 records · Page 3Linked to original sources
PubMed1987

Triplication of alpha-globin genes is responsible for unusual alpha 113Leu/alpha 113His-globin chain ratios in sheep.

By investigations at the DNA and protein level, it has been shown that in sheep a previously detected, presumed quantitative allele of the II alpha 113His gene, displaying a reduced efficiency (called the II alpha 113His decreases gene), is carried by a chromosome bearing three alpha-globin loci. In particular, five sheep having an alpha 113Leu/alpha 113His-chain ratio of about 13:1 (13:1 phenotype) possessed the -I alpha 113Leu-II alpha 113Leu-/-I alpha 113Leu-II alpha 113Leu-III alpha 113His decreases genotype. One sheep showing a alpha 113Leu/alpha 113His-chain ratio of about 3:1 (3:1 phenotype) had the -I alpha 113Leu-II alpha 113His-/-I alpha 113Leu-II alpha 113Leu-III alpha 113His decreases genotype, while one sheep having a chain ratio of about 6:1 (6:1 phenotype) carried the -I alpha 113Leu-II alpha 113Leu-II alpha 113His decreases-/-I alpha 113Leu-II alpha 113Leu-III alpha 113His decreases genotype. Nineteen sheep, displaying the common phenotypes, all possessed the alpha alpha/alpha alpha gene arrangement. Furthermore, the possible location of the gene with reduced efficiency and the expression of the three genes in the triple alpha-globin loci chromosome are discussed.

Animals↗
PubMed1987

A clinical study of Addison's disease.

Fifty-four patients affected by primary adrenocortical insufficiency have been retrospectively studied. Eighteen were affected by a tuberculous Addison's disease, 24 by an idiopathic Addison's disease and 12 by an unclassifiable form. Modality of arise, clinical presentation and association with other diseases are reviewed. The most useful laboratory and instrumental tests for the diagnosis are discussed and a diagnostic flow-chart is proposed.

Addison Disease↗
PubMed1987

[Clinical dosimetry in xeromammography using the low dose system].

The results obtained by utilizing low-dose plates in xeromammography are reported. Phantom experimental examinations and dosimetric measurements were made before using these plates. The new exposition data were then compared to those obtained with the old plates. Findings prove low-dose plates to be more sensitive--thus granting very good iconographic results with reduction of skin dose (about 30%) at FFD of 110 cm. The skin dose has been compared to that obtained with the most modern mammographs.

Female↗
PubMed1987

[Retrospective study of 177 patients admitted to the coronary unit in whom the diagnosis of myocardial infarct was excluded: subgroup at high risk for cardiovascular accidents].

In attempt to know prognosis of "threatening angina" we examined, after an average of 4 years, 177 patients hospitalized in CCU for myocardial infarction for whom the diagnosis was ruled out. Cardiac events mortality rate was of 22.4% (45% in the first six months); myocardial infarction occurred in 29.5% of the cases (71% within the twelfth month) with mortality rate of 56%. After Hospital discharge 30% of the patients had angina, whereas 27.3% was alive and completely asymptomatic. These results compared with infarctuated patients group discharged in the same period from same CCU prove "threatening angina" has worse prognosis. High morbidity and mortality in the first months require early diagnostic and therapeutic measures.

Aged↗
PubMedDate not supplied

MR characterization of hepatic lesions by t-null inversion recovery sequence.

Tissue characterization of focal hepatic lesions was performed employing an inversion recovery sequence with short repetition time and short inversion time (TI) values. Different and specific TI values, correlated to the in vivo measured T1 relaxation times, were used to null the signal intensity of each type of lesion. In 40 patients studied, we observed the nulling effect of normal liver in 10 of 10 cases with a TI of 136 ms, of metastases in 7 of 8 cases with a TI of 175 ms, of hemangiomas in 15 of 16 cases with a TI of 200 ms, and of cysts in 6 of 7 cases with a TI of 235 ms. A quantitative analysis of the nulled signal was performed by measuring the signal/noise values. A further qualitative and quantitative characterization was carried out by evaluating the signal intensity of hepatic lesions at the null point of normal liver. The method provided the possibility of discriminating different focal lesions with specificity values of 83-94%, according to the type of lesion.

Adult↗
PubMedDate not supplied

Intracavitary beta-interferon for the management of pleural and/or abdominal effusions in patients with advanced cancer refractory to chemotherapy.

Twenty-three cancer patients with pleural and/or abdominal effusion refractory to chemotherapy were treated with intracavitary beta-interferon after drainage. The overall response rate at 30 days was 35% for the whole group of patients, 25% for those with pleural effusion, and 40% for those with ascites. In 15 patients the mean time to re-accumulation of fluid after drainage only was 8.7 days, while it approached 30.3 days after intracavitary beta-interferon. This difference was statistically significant (P less than 0.001). The treatment was well tolerated with only mild and transient pain in 3 cases.

Adult↗