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Biomedical subjects

A Teuscher

Publications and source records attributed to A Teuscher.

At least 55 records · Page 3Linked to original sources
PubMed1980

In vitro and in vivo studies on glucagonoma tissue.

A 66 year old patient with diabetes had a necrolytic migratory erythema, weight loss and anaemia. Plasma immunoreactive glucagon (IRG) of 2465 pmoles/l (normal 35 +/- 5 SEM pmoles/l) suggested the existence of a glucagonoma which was confirmed by arteriography and subsequently removed by surgery. Although plasma IRG returned to normal, glucose tolerance and insulin secretion remained pathological. Plasma amino acid levels had been reduced but were corrected by surgery. Pancreatic polypeptide, however, 298 pmoles/l before was still 206 pmoles/l after the operation (normal 12-48 pmoles per litre). Column chromatography of plasma and tumor extracts showed quantitatively important IRG fractions with molecular weights above 9000 daltons, possibly precursors of glucagon. Beside a 50-fold IRG excess, the tumour concentrations of insulin and somatostatin were 4 to 150 times increased. By contrast, pancreatic polypeptide was present in normal amounts. Electron microscopic examination showed atypical A-cell granula and unusual abundance of mitochondria.

Aged↗
PubMed1979

[Immunologic studies with fully synthetic human insulin in patients with diabetes mellitus].

A group of 12 diabetic patients with insulin allergy previously documented by positive skin tests have been investigated with insulin of bovine, porcine and human origin and with a synthetic human insulin (CGP 12 831). In 3 patients clearly positive skin tests were found even against CGP 12 831. In lymphocyte transformation tests performed in these 3 cases, an increase of 3H-thymidine uptake was found when Actrapid was added. No increase was observed when CGP 12 831 was added.

Animals↗
PubMed1979

[The course of diabetes and clinical findings in glucagonoma].

A 66-year-old male patient with non-insulin-dependent diabetes of probably 20 years' duration presented with necrolytic migratory erythema, stomatitis, anemia and weight loss. Plasma-glucagon concentration measured with Unger's antibody 30-K was 8500 pg/ml, representing a hundredfold elevation. Two thirds consisted of high molecular glucagon fractions (10 000--40 000 Dalton). This may be an important index for detection of glucagonoma with endocrine activity. After excision of the glucagonoma the clinical syndrome was reversed and the patient recovered completely. Histological and histochemical investigation confirmed that the tumor was a glucagonoma. Despite complete removal of the tumor and a normal plasma glucagon concentration, the diabetes remained unchanged. Excessive hyperglucagonemia does not appear to play a primary role in the pathogenesis of this patient's diabetes.

Aged↗
PubMed1979

[The biological effect of purely synthetic human insulin in patients with diabetes mellitus].

Six patients with diabetes were treated with fully synthetic human insulin (CGP 12 831) for durations of 3 days (4 patients), 4 days and 13 days (1 patient each). In every case, clinical signs of hypoglycemia were registered and measured by blood sugar determinations. Two patients with insulin-dependent diabetes were maintained on synthetic insulin. Ketoacidosis was corrected in 1 patient. In a hyperglycemic diabetic with failing response to oral antidiabetics, synthetic insulin normalized the hyperglycemia. In 2 juveniles with recent onset of diabetes, every injection of synthetic insulin was followed by a fall in blood sugar. In a normal individual, hypoglycemia developed after a single injection of 8 units. The synthetic human insulin was well tolerated. The 6 diabetics showed evidence of full biological action of the fully synthetic insulin, as was expected from animal experiments.

Adult↗
PubMed1978

Effect of propranolol on fetal tachycardia in diabetic pregnancy.

Propranolol was administered during the last 20 days of pregnancy to a diabetic woman because of fetal tachycardia (heart rate approximately 200 beats/min). With a daily dose of 160 mg of propranolol, a fetal heart rat of 120 to 160 beats/min could be achieved. Blood concentration of propranolol was measured in the mother and infant after birth. The level in the neonatal blood was 20 percent of the maternal sample, which is definitely higher than expected from animal experiments. No undersirable effect of propranolol treatment was detected. Postpartum, the infant demonstrated paroxysmal supraventricular tachycardia, and propranolol was again essential in maintaining a normal rate.

Adult↗
PubMed1976

[Correlations between clinical findings and therapeutic measures and the course of diabetic retinopathy].

A review is presented of recent literature on clinical findings and therapy in relation to the course of diabetic retinopathy. A report is then given on personal results with hypophysectomy in 15 diabetics with progressive retinopathy. The observation period is 16 years. The course of retinopathy is related to growth hormone findings, which have been determined in a longterm program. Mean survival after trans-sphenoidal hypophysectomy was 4 1/3 years (1 8/12 to 8). There is no clear evidence that impending blindness could be arrested in the whole group, but there was a temporary halt in individual diabetics. In one patient, growth hormone treatment was investigated as a means of improving renal function. The diabetic retinopathy findings did not change during growth hormone treatment.

Blood Glucose↗
PubMed1976

Evaluation of an instruction programme on diabetes diet by means of a teaching machine.

In 119 patients with diabetes, student nurses, social workers, dietitians and medical students a pretest was carried out with multiple-choice questions on the subject of diabetes diet. The group was then exposed to programmed diet instruction with a teaching machine. There was a significant learning effect as measured by the score differences with identical and analogue post-tests. Programmed self-teaching with feed back by multiple-choice questions seems to be an efficient method of instruction of basic facts of nutrition for diabetics thus enabling the physician to spend more time on the patient's personal problems.

Diet, Diabetic↗
PubMed1975

[Frequency of juvenile diabetes mellitus in the Canton Bern (Switzerland)].

The prevalence of juvenile diabetes in the under-20 age group was found to vary from 5.2 to 9.8 per 10 000 juvenile population in Canton of Bern (Switzerland), varying with the region. The overall prevalence was 5.9/10 000. There were twice as many juvenile diabetics in the mountain region than in the other two geographically different areas. The survey was carried out with the help of practitioners and chiefs of hospital services. Participation was close to 100%.

Adolescent↗
PubMed1975

[The place of "monocomponent" insulins in diabetes mellitus therapy].

The chemical and biochemical properties of highly purified insulin (termed "monocomponent insulin") are discussed. The clinical indications for this mc-insulin are immunologic side effects of conventional insulin therapy such as resistance, allergy and lipoatrophy. Furthermore, highly purified insulins can be tried in high insulin requirement, in juvenile diabetes and intermittent insulin therapy. Case histories for these clinical indications are presented. It is advised that the use of mc-insulin should be restricted to precise clinical indications until enough pure pig insulin is available for treatment of all insulin-dependent diabetics.

Animals↗