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Biomedical subjects

A Thulin

Publications and source records attributed to A Thulin.

At least 37 records · Page 2Linked to original sources
PubMed1981

Cholangiocarcinoma in a patient with biliary cysts.

A 15-year-old girl with multiple intra- and extrahepatic biliary cysts is presented. At a primary laparotomy a massive dilatation of the choledochal duct was found and a choledochocysto-duodenostomy was made. Initially the patient recovered but 1 1/2 years later a mass reappeared under the right costal arch. At a second laparotomy multiple neoplastic changes were found on the right and left liver lobes. Histologic examination of biopsies from the liver showed the picture of a cholangiocarcinoma.

Adenoma, Bile Duct↗
PubMed1981

Premalignant lesions of the periampullary region. Report of two cases.

Two patients with adenomatous lesions of the periampullary region of the duodenum are presented. In one patient the tumour was located in the most distal part of the common bile duct. The other patient had a tumour originating in the mucosa of the papilla of Vater and extending into the distal part of the common bile duct. The diagnostic and therapeutic problems with these lesions are discussed with respect to their precancerous nature.

Adenoma↗
PubMed1980

Wilkie's syndrome--a rarity?

Six cases are reported of vascular compression of the duodenum giving rise to duodenal and gastric dilatation, a condition which may be more common than generally recognized. The pathophysiology, difficulties of diagnosis and treatment are also discussed. Recognition of this disease is essential otherwise it may be fatal.

Adolescent↗
PubMed1980

Osteogenic sarcoma of the breast. Report of a case.

The clinical, mammographical, cytological and histological features of a mammary osteogenic sarcoma are reported. The tumor, which was removed by only local excision, had suddenly appeared in the same breast from which previously an intraductal papilloma had been removed. Nearly three years after the operation there is no indication of recurrence.

Aged↗
PubMed1980

Clinical and laboratory findings in patients subjected to laparotomy for suspected acute appendicitis.

In a retrospective study, clinical and laboratory findings in 454 patients subjected to laparotomy for suspected acute appendicitis were evaluated. A normal appendix was found in 25% of the total series and was twice as common in female as in male patients. Perforated appendicitis was present in 8% of the series, most commonly in the youngest (less than 5 years) and the oldest (greater than 40 years) age groups. The incidence of severe appendicitis increased with the duration of the preoperative abdominal symptoms. Of the patients with a 'laboratory profile' including fever and leukocytosis, 44% had gangrenous or perferated appendicitis. Of those who additionally had elevated ESR (greater than 20 mm), 62% showed a gangernous or perforated appendicitis. The overall incidence of wound infection was 13.9%. Wound infection was closely related to the state of the appendix. The results thus indicated that patient's age, duration of abdominal symptoms and the 'laboratory profile' are important parameters for assessment of clinically suspected acute appendicitis.

Acute Disease↗
PubMed1979

Skeletal scintigraphy in the inital assessment of women with breast cancer.

The results of 99mTc bone scanning have been retrospectively analyzed on 467 women admitted with a newly diagnosed breast cancer. The outcome of skeletal scintigraphy has been studied with reference to various prognostic variables. 9.8% of the women exhibited a positive scintigram. We could not find any influence of the tumour position on the frequency of positive bone scans. Age in relation to the menopause affected the rate of positive scans in that about three times as many positive scans were recorded in post menopausal women than in those who had not reached the menopause. Clinical staging according to the TNM system as well as the histological status of the axillary nodes correlated well with the rate of scintigrams that indicated a disseminated cancer disease. The tumour size, as measured in the operation specimen, strongly affected the frequency of positive and suspicious scans in accord with the prognostic significance of this parameter. The role of skeletal scintigraphy for an adequate staging of breast cancer patients is discussed.

Adult↗
PubMed1978

Secretory, motor and vascular effects in the sublingual gland of the rat caused by autonomic nerve stimulation.

The influence of the autonomic nerves on sublingual glands of rats was studied. Stimulation of the chorda-lingual nerve evoked a lively flow of saliva and was also thought to contract the myoepithelial cells in the gland. Sympathetic nerve stimulation, on the other hand, usually evoked no secretion and did not cause any motor responses in the sublingual gland. The glandular blood flow was increased by chorda-lingual nerve stimulation, and this vasodilatation persisted also when atropine had been administered. Sympathetic nerve stimulation decreased the sublingual blood flow; this vasoconstrictor effect was mediated via activation of alpha-adrenoceptors.

Animals↗
PubMed1977

Hyperosmolality and pancreatic blood flow.

In the cat pancreas, close intra-arterial infusions of hypertonic xylose, glucose and sucrose solutions caused a marked vasodilatation but no secretion. The magnitude of the vasodilator response correlated with the degree of induced glandular hyperosmolality but not with the substance per se. Stimulation of the vagus nerve as well as infusion of secretin and/or CCK evoked a pronounced secretion and a small to moderate increase in pancreatic blood flow, but did not significantly change the plasma osmolality in the venous effluent from the gland. Bradykinin, papaverine and isoprenaline caused large increments of pancreatic blood flow; none of these drugs evoked secretion nor did they change the venous osmolality. It is concluded that blood-bone hyperosmolality is a strong stimulus for pancreatic vasodilatation, but the functional hyperaemia of this gland is due to factors other than regional tissue hyperosmolality.

Animals↗
PubMed1976

Motor and secretory effects of nerves on the parotid gland of rat.

The influence of parasympathetic and sympathetic nerves on the parotid gland of the rat was investigated. It was found that both divisions of the autonomic nerves evoke secretion and probably also motor effects in this gland. Secretion elicited on sympathetic stimulation was mediated both via alpha- and beta-adrenoceptors, while motor effects were mediated via alpha-adrenoceptors. On stimulation of the autonomic nerves a lower duct pressure was reached in the parotid than in the submaxillary gland, and on sympathetic nerve stimulation the flow of saliva always started later from the parotid than the submaxillary gland. These findings are discussed in the view of the different arrangement of the myoepithelial cells in the 2 glands.

Animals↗
PubMed1976

Blood flow changes in the submaxillary gland of the rat on parasympathetic and sympathetic nerve stimulation.

Blood flow and secretion from the submaxillary gland of the rat was recorded. Stimulation of the chordalingual nerve evoked vasodilatation which was little, it at all, decreased after administration of atropine. The secretion evoked on parasympathetic nerve stimulation was greatly reduced but not totally abolished by parasympatholytic agents. Stimulation of the cervical sympathetic trunk evoked secretion, which was mediated both via alpha and beta-adrenoceptors and vasoconstriction which was abolished by dihydroergotamine, and thus seemed to be mediated via alpha-adrenergic receptors. After alpha-adrenoceptor blockade vasodilatation was seen on sympathetic nerve stimulation. This was abolished by the beta-adrenoceptor blocking agent propranolol.

Acetamides↗
PubMed1976

Secretory and motor effects in the submaxillary gland of the rat on intraarterial administration of some polypeptides and autonomic drugs.

Bradykinin, oxytocin, physalaemin and some autonomic drugs were injected in to the common carotid artery. Physalaemin evoked secretion and a pressure rise in the submaxillary duct. A duct pressure rise could be elicited by bradykinin which did not evoke secretion. Autonomic blocking agents did not diminish secretion evoked by physalaemin and did not change pressure responses elicited by bradykinin or physalaemin. Neither secretion, nor duct pressure changes could be recorded after administration of oxytocin. In agreement with previous experiments secretion evoked by autonomic drugs was found to be mediated via cholinergic, alpha- and beta-adrenergic receptors, while motor effects were due to activation of cholinergic and alpha-adrenergic receptors.

Animals↗
PubMed1976

Secretory and structural effects of 6-hydroxy-dopamine on normal parotid glands of rats, and at different times after surgical sympathectomy.

The effects of i.v. 6-hydroxydopamine (6-OHDA), 100 mg/kg, have been studied on parotid glands of rats at 12, 24, 48, 72 hr and 3 weeks after avulsion of the right superior cervical sympathetic ganglion. The salivary flow from normal left control glands and from right glands 12 hr after ganglionectomy were similar, but at longer times after ganglionectomy the secretory response from the test glands was greatly reduced. Morphological assessment showed that 6-OHDA induced a massive depletion of secretory granules from all control glands and also at 12 hr after ganglionectomy but at 48 and 72 hr there was considerably less depletion of granules on the ganglionectomized side. It is thought that at the longer times after ganglionectomy the secretion from the test glands is caused by circulating catecholamines released by the action of 6-OHDS on adrenergic nerves elsewhere, plus a possible small direct secretogogue effect oomy are thought to be attributable to the release of catecholamines from adrenergic nerves within the gland.

Animals↗
PubMed1975

Structural changes associated with parotid "degeneration secretion" after post-ganglionic sympathectomy in rats.

Parotid glands of rat have been examined 12, 24 and 48 hours after avulsion of the cervical sympathetic ganglion and compared with normally innervated left glands. Formaldehyde-induced fluorescence showed a relatively normal complement of adrenergic nerves at 12 hours but most of the nerves had lost their noradrenaline content by 24 hours and no fluorescent nerves were detected at 48 hours. Ultrastructural degenerative changes in axons were rare at 12 hours, common at 24 hours, and the degenerating axons appeared to have disappeared by 48 hours. The glands looked whitish and pale and similar to the controls at 12 and 48 hours but were pinkish and oedematous on the sympathectomised side at 24 hours. Correspondingly the acini were loaded with secretory granules at 12 and 48 hours but were extensively depleted of granules at 24 hours. This loss of granules is considered to be due to sympathetic "degeneration secretion" caused by the release of noradrenaline from the degenerating adrenergic nerves between 12 and 24 hours after ganglionectomy. This is thought to be the first example of morphological change resulting from "degeneration activation" to be recorded microscopically.

Animals↗
PubMed1975

Changes in parotid acinar cells accompanying salivary secretion in rats on sympathetic or parasympathetic nerve stimulation.

Morphological and secretory effects of stimulating autonomic nerves have been studied in parotid glands of rats. Sympathetic stimulation evoked a slow flow of saliva which had a high concentration of amylase. After long term sympathetic stimulation secretory granules were heavily depleted from the parotid acinar cells. Parasympathetic stimulation evoked a copious flow of saliva with a low concentration of amylase. However, at high frequency stimulation the total amount of amylase secreted on parasympathetic stimulation was as great or even greater than on symphatetic stimulation, nevertheless, any loss of secretory granules from the acinar cells was very small. It is concluded that secretion of parotid acinar granules in the rat is prinicipally a sympathetic function. Secretion of fluid is more effectively produced by parasympathetic stimulation and much of the amylase in such saliva appears to have arisen from sources other than the secretory granules.

Amylases↗
PubMed1975

Influence of autonomic nerves and drugs on myoepithelial cells in parotid glands of cat.

When a single electrical shock is applied to either the parasympathetic or to the sympathetic nerves a pressure rise is seen in the parotid duct of the cat, probably due to myoepithelial cell activation. No secretion occurred on single impulse stimulation. When repetitive stimulation was used both divisions of the autonomic nervous system could evoke secretion. The motor response to sympathetic stimulation was mediated via alpha-receptors while secretion mainly was mediated via beta-receptors.

Animals↗