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Biomedical subjects

A Timme

Publications and source records attributed to A Timme.

5 recordsLinked to original sources
PubMed1977

Nocardia infections in congenitally athymic (nude) mice and in other inbred mouse strains.

The mortality rate and histopathological features of Nocardia asteroides and Nocardia brasiliensis infections in congenitally athymic (nude) mice of ICR and C3H/eB origins were quite different from what we found for Swiss white mice and other inbred mouse strains (namely, C57/BL/6J, New Zealand Black, BALB/c, CBA/LAC, and C3H/eB). The immunocompetent littermates of the congenitally athymic mice occupied an intermediate position between their athymic siblings and Swiss white mice in terms of their responses to both these organisms. Macrophage ingestion and destruction of N. brasiliensis, as demonstrated by electron microscopy, was found to occur. The T-lymphocyte appears to be an essential component in normal mouse resistance to infection by both N. asteroides and N. brasiliensis.

Animals↗
PubMed1977

Pancreatic islets of malnourished rats: quantitative histologic and electron microscopic findings.

Young rats were maintained for three weeks on a low-protein diet. These animals developed many of the features of human protein-calorie deficiency, including dextrose intolerance and diminished insulin release. Quantitative histologic and ultrastructural studies showed that malnourished rats had (1) a reduced total pancreatic islet volume, and (2) a preponderance of pale granules in the B cells. It is suggested that pale B granules may contain increased amounts of insulin, which accumulate in the cells because of defective insulin release. The mechanism responsible for this has not been elucidated.

Animals↗
PubMed1976

Diffuse arteritis, long-term immunosuppression and malignancy.

A 45-year-old White man presented with multiple aneurysm formation and severe constitutional symptoms, the control of which entailed long-term corticosteroid therapy. Early in the patient's clinical course, two aneurysms were resected, and at subsequent postmortem examination the vascular lesions were found to be inactive and fibrosed, which suggested that the corticosteroids had been effective in controlling the inflammatory reaction. Of special interest was the development of diffuse lymphoma of the large cell type (histiocytic lymphoma) late in the course of the disease. This report emphasises the association between immunosuppressive therapy and subsequent neoplasia, and stresses the need for caution in the administration of these agents to patients whose condition is benign.

Aortic Aneurysm↗