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Biomedical subjects

A Tobin

Publications and source records attributed to A Tobin.

31 records · Page 2Linked to original sources
PubMed1989

Risk factors in inflammatory bowel disease.

A patient with inflammatory bowel disease may have several risk factors, including host defence and familial and environmental factors. Host defence factors include neutrophil and complement abnormalities and increased intestinal permeability. This may explain why elemental diets are effective treatment in Crohn's disease. Food is a major factor affecting the intestinal tract, and the considerable change in dietary habits during this century may explain why Crohn's disease has become more common. There is a geographic difference in the distribution of the disease. This could be due to difference in fish consumption. Fish oil has been shown to be effective in an uncontrolled study in the treatment of ulcerative colitis. This needs to be confirmed by ongoing controlled studies. Very few data have been published on the dietary habits of different countries. There is a need for a uniform dietary assessment that can be applied in a multicentre study. These studies would involve much co-operation but would yield important clues in the aetiology of inflammatory bowel disease.

Animals↗
PubMed1986

Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms.

A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA sequences and restriction fragment length polymorphisms, was evaluated by the LOD score method with requisite assumptions for mode of inheritance, age-of-onset and incomplete gene penetrance. Genes for pro-opiomelanocortin and glutamic acid decarboxylase, which have been implicated in the etiology of the disease in rat models, were excluded as being responsible for the disease state in this family. Other regions of the genome were also excluded using DNA probes for other genes and random "unique" sequences.

Adolescent↗
PubMed1980

Effect of NAD on Malate Oxidation in Intact Plant Mitochondria.

Potato tuber mitochondria oxidizing malate respond to NAD(+) addition with increased oxidation rates, whereas mung bean hypocotyl mitochondria do not. This is traced to a low endogenous content of NAD(+) in potato mitochondria, which prove to take up added NAD(+). This mechanism concentrates NAD(+) in the matrix space. Analyses for oxaloacetate and pyruvate (with pyruvate dehydrogenase blocked) are consistent with regulation of malate oxidation by the internal NAD(+)/NADH ratio.

Journal Article↗
PubMedDate not supplied

A case management approach to immunizing patients at high risk for influenza.

The influenza season affects not only the people afflicted with influenza, but the healthcare system as a whole. An estimated dollar 12 billion is the annual cost to care for these patients. An existing problem is that although there is an immunization for influenza, many patients at high risk are not immunized. This article will describe an innovative program of a large Midwest suburban hospital to immunize patients at high risk.

Case Management↗
PubMedDate not supplied

An hypothesis about heroin addiction, murder, prostitution, and suicide: acting out parenting conflicts.

From interviews with forty subjects, we have developed a preliminary hypothesis which can be refined and deepened and then tested by psychotherapeutic investigation. These murderers, prostitutes, heroin addicts and successful suicides all demonstrated various aspects of difficulty with their capacity for reciprocal tenderness. This arose from their experiences of exploitation and derprivation with their own parents. Their unique characteristics included primitive rage, insatiable demands and capacity for unconflicted manipulation. These characteristics colored the expression of their intrapsychic conflict between the wish to parent successfully and the fear of perpetrating their own childhood experiences upon their children.

Acting Out↗