A case of drug-induced (?) pulmonary hypertension.
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Appetite Depressants↗
Biomedical subjects
A Torp
Publications and source records attributed to A Torp.
Fluorescence of catechol amines and related compounds condensed with formaldehyde.
The reaction under mild conditions between formaldehyde and phenylalanine and phenylethylamine derivatives has been studied. When the amines included in a dried protein film were exposed to formaldehyde vapour a very intense green to yellow fluorescence was given only by those that as well as being primary amines also have hydroxyl groups at the 3 and 4 positions (3,4-dihydroxyphenylalanine, dopamine, noradrenaline). The 3-OH group seems to be essential for the reaction. The catechol amines, which are secondary amines (adrenaline, epinine), gave a much weaker fluorescence that developed more slowly. The results obtained on further examination of the reaction favour the view that the amines primarily condense with formaldehyde to 1,2,3,4-tetrahydroisoquinolines which are involved in a secondary reaction to become highly fluorescent and at the same time insoluble. This secondary reaction may be a binding to protein, an oxidation with the formation of double bonds in the heterocyclic ring, or both.
Catecholamines↗
Myocardial biopsy in a case of cardiomyopathy and partial alpha-a antitrypsin deficiency with liver engagement.
A case of partial alpha-1 antitrypsin deficiency with liver engagement and a biopsy-verified congestive cardiomyopathy is reported. The possibility of a connection between these two diseases is discussed in view of recent literature.
Biopsy↗