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Biomedical subjects

A Torralba

Publications and source records attributed to A Torralba.

At least 37 records · Page 2Linked to original sources
PubMed1981

Urinary excretion and circadian rhythm of cyclic-AMP and cyclic-GMP in childhood.

Normal urine values of cyclic-AMP and cyclic-GMP were determined in healthy children, using a competitive protein binding and a radioimmunoassay technique respectively. Neither sex nor age affected the cyclic nucleotides excretion. A circadian rhythm in the urinary excretion of cyclic-AMP was observed throughout a 20 h period. The peak excretion occurred at 16.00 h, while minimal excretion was at 24.00 h. The differences observed between the periods of highest and lowest excretion of cyclic-GMP were not statistically significant.

Binding, Competitive↗
PubMed1979

Septic shock in pediatrics.

A review of the septic shock syndrome in pediatrics, analyzing its actual incidence in clinical practice, etiopathological factors, physiopathology, clinical manifestations in the different stages of the disease, diagnostic criteria, prognostic, and treatment is presented.

Acute Kidney Injury↗
PubMed1979

3,3-Bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (BHMI), the active metabolite of the laxative sulisatin.

The disodium salt of the sulphuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (sodium sulisatin, Laxitex), a synthetic laxative with two phenolic groups esterified with sulfate, has been studied in order to find out if its laxative properties may be attributed to the unaltered compound or to its diphenolic derivative BHMI. We first studied the effect of homogenates of the gastrointestinal tract of rats and of rat cecal content of the hydrolysis of sulfate ester bonds of sulisatin. Results show that sulisatin can be hydrolyzed by cecal content while homogenates of stomach, small intestine and large intestine have no hydrolytic effect. Sulisatin is also a substrate of arylsulfate sulphohydrolase obtained from the snail Helix pomatia. The unaltered drug has no effect on the intestinal motility since it does not change the intestinal transit speed in rats pretreated with neomycin sulfate. Sulisatin (1.5, 3 and 6 mg) is unable to inhibit water absorption in rat colon while small amounts of BHMI (15 and 30 micrograms) may inhibit it significantly. It is concluded that sulisatin passes unaltered through the small intestine and is hydrolyzed in the large intestine by the intestinal microflora to its diphenolic derivative BHMI, which is responsible for the laxative activity of the drug.

Animals↗
PubMed1977

Influence of fosfomycin on intestinal disaccharidases in rats.

The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disaccharides with a glucose-oxidase-peroxidase reagent and a chromogen (Glucostat). The results obtained in animals treated with a daily dose of 1 g/kg fosfomycin for 6 consecutive days are compared with the corresponding results of animals that received 1 ml/day of saline solution during the same period. Our conclusion was that fosfomycin has no effect on the intestinal disaccharidases in rats.

Administration, Oral↗
PubMed1976

Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.

The influence of DAN-603 (disodium salt of sulphuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone) on the propulsive motility of the rat digestive tract was studied by means of indicators (charcoal and pyrvinium pamoate) and radioactive tracers (133BaSO4). The results showed that DAN-603 increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying.

Animals↗
PubMed1976

[Serum ige levels in healthy children (author's transl)].

Serum IgE levels have been measured in a group of 55 healthy children from 2 to 10 years of age. The IgE mean value increases with the age but no sexual differences have been found. The numerical distribution of the different genotypes observed in the unselected population, follows the Hardy-Weinberg law, which describes the segregation of two alleles at a single locus.

Age Factors↗
PubMedDate not supplied

Evidence of autoantibodies in rats with adjuvant-induced arthritis.

The adjuvant arthritis, induced by subdermal injection of heat-killed mycobacteria dispersed in oil, is a form of chronic arthritis in rats. In this paper, the production of autoantibodies against immunoglobulins in rats with adjuvant arthritis was examined by means of the latex agglutination technique. A significant agglutination titre was found in arthritic rats on day 14 of induction and these values decreased throughout the studied period. The positive results in arthritic animals were 100, 86, 86, 29 and 29% on 14, 21, 28, 35 and 42 day after the induction, respectively. These results were significantly higher than those found in control animals. Correlation between latex titre and adjuvant-induced systemic swelling was observed. Treatment with benoxaprofen from day 14, produced a decrease in the latex titre and the values reached normal levels after two weeks of treatment.

Animals↗