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Biomedical subjects

A Torras

Publications and source records attributed to A Torras.

90 records · Page 5Linked to original sources
PubMed1980

[Lupus nephritis: clinicomorphological manifestations (author's transl)].

Forty patients with systemic lupus erythematosus have been evaluated for clinicopathological evidence of renal involvement. Average age at the onset of the disease was 23 years; 90 percent of the patients were women. Indications for renal biopsy included clinical symptoms of nephropathy (34 patients) and signs of immunological activity (6 patients(. All biopsied specimens were examined under light microscope; 28 of them under immunofluorescence, and 18 under electron microscope. Histological classification was as follows: I) Normal kidney (2 patients); II) mesangial glomerulonephritis (6 patients); III) focal glomerulonephritis (10 patients); IV) diffuse proliferative glomerulonephritis (19 patients), and V) membranous glomerulonephritis (3 patients). Six patients had no clinical nephritis, two of them had normal kidneys and four had a mesangial glomerulonephritis. Patients in groups III, IV, and V showed clinical and biological evidence of renal involvement. Highest incidence of renal failure, nephrotic syndrome or high blood pressure was found among cases in group IV. Group IV accounted also for the highest mortality rate. Clinical course of 25 cases (1 of type II, 8 or type III, and 16 of type IV) on corticosteroid therapy for an average follow-up of 22.8 months has showed greater clinical improvement (proteinuria and renal function) of nephropathy type III than nephropathy type IV. Renal biopsy is a useful diagnostic and prognostic method in patients with systemic lupus erythematosus, even in those cases without clinical evidence of renal disease.

Adolescent↗
PubMed1980

[Hemolytic-uremic syndrome in the adult (author's transl)].

This article presents six cases of hemolytic-uremic syndrome, defined as the combination of acute renal insufficiency, microangiopathic hemolytic anemia, and thrombocytopenia, in six adult patients, two men and four women, between 20 and 52 years old. Three of the cases were considered idiopathic, two secondary to the use of oral contraceptives, and one appeared after an abortion. All of the patients presented severe hypertension, frequently accompanied by increased renin levels; in no cases was there any important coagulation disorder. In all of the biopsies there were lesions denoting intravascular thrombosis in the arterioles and medium-sized arteries of the kidney, as well as thickening of the glomerular basal membrane. Immunofluorescence was positive for fibrinogen and C3 in the majority of biopsies examined. Two patients suffered acute pancreatitis, hypertension having perhaps been an important factor in this complication. One of the two patients died as a result of acute hemorrhagic pancreatitis and was the only death in the series. Of the five remaining subjects, three required periodic hemodyalisis and the other two presented a considerable degree of chronic renal failure, which confirms that the prognosis for the hemolytic-uremic syndrome is much worse for the adult than for the child.

Adult↗
PubMed1980

Familial IgA nephropathy: report of two cases and brief review of the literature.

Immunoglobulin A nephropathy developed in two siblings who shared the DRw4 antigen but who were otherwise HLA-A, -B, and -C unrelated. It is suggested that a genetically induced alteration in the immune response can cause some of the cases of mesangial IgA glomerulopathy and that close blood reltaives of patients with this disease should be checked for the possible existence of renal abnormalities.

Adult↗
PubMed1979

[Nephrotic syndrome by diffuse mesangial sclerosis (author's transl)].

This case deals with a 15-month old male child affected with a nephrotic syndrome resulting in grave chronic renal failure, determined histologically as diffuse mesangial sclerosis. The most frequent causes of nephrotic syndrome in the first year of life are analyzed along wiht their diagnostic differential, with special attention to the Finish or microcystic congenital nephrotic syndrome and to diffuse mesangial sclerosis. In the discussion contradictions existing in the bibliography on diffuse mesangial sclerosis are shown in its clinical and developmental aspects as well as the prognostic and even in the pathological anatomy, which leads us to believe that this illness may be more complex than what it appears, and subdividing it into illnesses of different etiology, development and prognosis; or that some of the cases. described as such may not be the same as those described by R. Habib in 1973. In the present case the deposits of C3 and IgM are worth noting, as they were not described in the other 11 cases, also the study done with the electron microscope, which also was not done in the previous cases.

Complement C3↗
PubMed1979

Renin-induced massive proteinuria in man.

A 30 year old man developed renovascular hypertension and extreme elevation of plasma renin activity. Daily proteinuria ranged from 13 to 31 g. There were no criteria for the diagnosis of malignant hypertension. A primary glomerulopathy was excluded by a basically normal renal biopsy from the unprotected kidney. On electron microscopy the epithelial cell foot processes were not fused, thus ruling out simultaneous lipoid nephrosis. The source of renin was removed by means of a left nephrectomy. Following the procedure the patient became normotensive, the renin values normalized and the proteinuria disappeared. The results suggest that renin can cause significant proteinuria in man.

Adult↗
PubMedDate not supplied

Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.

Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS). Pulmonary impairment in the HUS is rarely reported in the literature, and no reports of pulmonary hemorrhage, as a clinical feature of the HUS, have been documented. We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding. Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy. It is extremely resistant to standard treatment, and confers a poor prognosis for this disease.

Adenocarcinoma↗