PubMed1986
We have revised the concept of pseudolymphoma, some of its classifications and its differences with the malignant lymphoma, which sometimes are only an evolution, not existing other elements of judgement. We publish the summary of ten lymphocytoma cutis cases studied by us, which we believe are the paradigm of the B pseudo-lymphoma due to the clinical and hystological controversy in our patients. One of them shifted to malignant lymphoma after 30 years of evolution as a lymphocytoma. Under the denomination of lymphocytoma we believe should be included a group of not well defined process, of unknown etiology, described in literature under the names of "Spiegler-Fendt Sarcoid", "lymphadenosis benigna cutis", "benign lymphocytic reticulosis" and "lymphocytic infiltration of Jessner" all of them with clinical evidences of papulo-tuberous lesion, covered by a yellowish to brownish red erythematous skin with the appearance of "orange skin" with no ulcers and usually located on the head (nose, forehead and scalp) or in any other part of the skin, looking sometimes, like the malignant lymphoma. Histologically characterized by a dense lymphocytic reaction proliferation; polymorphous with a diffuse or nodular pattern, characteristic in B pseudolymphoma. We should establish the differences between at least two clinical forms: the one of single lesion, of multiple lesions in the same area, called therefore single and multiple regional form, each one with its own characteristics and with certain clinical and hystological relations: single-Nodular and multiple-diffuse. The existence of important adenopathies in the multiple form, its clinics, its long evolution and its developing in malignant lymphoma in one of our cases makes us especially aware of this form and we strongly recommend to keep a lifetime control.