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Biomedical subjects

A Trifaud

Publications and source records attributed to A Trifaud.

At least 19 recordsLinked to original sources
PubMed1986

[Pre and postoperative chemotherapy of osteosarcoma with an adriamycin-cisplatin combination. Risks of a neoadjuvant chemotherapy which is not sufficiently effective].

The authors evaluated a new protocol of neoadjuvant chemotherapy for osteosarcoma, easier to manage and different from T10. The good results obtained with the postoperative ADR-CDDP association led us to undertake a pilot study between 1982 and 1984, using ADR-CDDP as preoperative chemotherapy. The records of sixteen patients were available for follow-up. The average age of the patients was 19.9 years. Patients received two or three preoperative courses, and a total of six identical courses. Tolerance was good. Pain usually disappeared but this was often misleading because associated with radiological and/or clinical tumor progression, low histological necrosis or poor outcome. The continuous disease-free survival actuarial rate was less than 57 and 40% at 18 months and two years respectively. The actuarial survival rate was 87% at one year and 65% at two years respectively. Disappointing results of this preoperative protocol, compared to results with the SO4 78 or T10 protocols for example, led to publish these data early in order to underline their potential dangers. As a result, we stopped our study. The charter of pilot studies justifies this publication. As well, these data point out the necessity of very close follow-up of neoadjuvant chemotherapy by sophisticated medical imaging. Neoadjuvant chemotherapy, if ineffective, must be stopped early, and should lead to surgery, followed by adequate postoperative chemotherapy.

Adolescent↗
PubMed1986

[Experiences and perspectives on adjuvant chemotherapy in osteogenic osteosarcoma].

This article analyses the relevance of the published results of adjuvant chemotherapy in osteogenic osteosarcomas. It discusses the causation and prospects for treatment particularly the details of the chemotherapy, with reference to mono- or poly-chemotherapy, the influence of the dose and of the interval of administration, and also the value of pre- and post-operative chemotherapy. It is apparent that intensive pre-operative chemotherapy limited to 4 weeks is a reasonable mean of distinguishing the good responders. The problem of the choice of therapy for bad responders is also discussed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1981

[Assessment of activity in bone tumours by telethermography (author's transl)].

The assessment of activity in bone tumours after irradiation is somewhat uncertain. In most cases, the process of healing cannot be assessed. The authors propose the use of tele-thermography, which was used 14 patients. In 8 cases, amputation was performed when tele-thermography showed persistent activity. In all cases, secondary microscopic examination of the amputated limb showed remaining active tumour in spite of negative radiological appearances. In 6 cases, in which tele-thermography was negative, the limb was not amputated with no recurrence up to the present time. The follow up study has varied from 15 months to 5 years. The authors consider that this technique is of great value in the assessment of the activity of irradiated sarcomata.

Amputation, Surgical↗