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Biomedical subjects

A Tsuboyama

Publications and source records attributed to A Tsuboyama.

At least 19 recordsLinked to original sources
PubMed1989

Behenoyl cytosine arabinoside, aclacinomycin A, 6-mercaptopurine, and prednisolone combination therapy for acute non-lymphocytic leukaemia in adults.

38 consecutive, previously untreated adult patients with acute non-lymphocytic leukaemia (ANLL) were treated with BHAC-AMP (N4-behenoyl-1-beta-D-arabinofuranosyl-cytosine, aclacinomycin A, 6-mercaptopurine, and prednisolone) therapy between March 1980 and February 1985. 25 patients (65.8%) achieved complete remission (CR). Median CR duration and median survival of patients who achieved CR were 14, and 24 months, respectively. The Kaplan-Meier analysis revealed a probability for remaining in CR of 18.0% at 5 years. Analysis of failure cases revealed that most of them were due to resistant disease. Major toxicities were infection, diarrhoea, liver dysfunction, nausea and vomiting but these were acceptable. The results indicate that BHAC-AMP therapy is comparable to the regimen with daunorubicin and cytosine arabinoside and a further clinical trial is necessary for previously untreated adult patients with ANNL.

Aclarubicin↗
PubMed1986

Morphological and immunological change in the predominant type of leukaemic cells in a patient with T-cell chronic lymphocytic leukaemia.

A case of T-cell chronic lymphocytic leukaemia is described. Intracerebellar tumour was demonstrated by the characteristic feature of contrast-enhanced computerized tomography and was evidenced by surgical procedure. Histological examination revealed lymphocyte infiltration in the cerebellum. Initially, the majority of leukaemic cells were mature, medium-sized lymphocytes with surface marker phenotype of E+, OKT3+, OKT4+, OKT6-, OKT8-. In the terminal stage, large atypical lymphocytes which were morphologically distinct from the original lymphocytes and had different surface marker phenotype of E+, OKT3+, OKT4-, OKT6-, OKT8+, Leu7+ became increasingly prominent. The remaining medium-sized lymphocytes were morphologically and immunologically unchanged. Subsequently, the disease developed to a more aggressive pattern and the patient died in spite of chemotherapy.

Adult↗
PubMed1985

Long arm deletion of chromosome 5 in a case of chronic myelomonocytic leukemia.

The 46,XY,del(5)(q31),del(12)(p11) and 46,X,-Y,del(5)(q31),del(12)(p11), +mar clones were found in the bone marrow cells of a 64-year-old Japanese man with chronic myelomonocytic leukemia (CMML). Although the 5q- anomaly has been reported to occur in various hematologic disorders, a literature survey of CMML cases revealed that the present case is the first instance of CMML with the 5q- anomaly. The possible significance of the chromosome findings is discussed.

Bone Marrow↗