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Biomedical subjects

A Tsunawaki

Publications and source records attributed to A Tsunawaki.

At least 19 recordsLinked to original sources
PubMed1998

Treatment of Fetal Premature Ventricular Contractions by Administering Propranolol Hydrochloride Orally to the Mother.

> Frequent fetal premature ventricular contractions were diagnosed at 39 weeks of gestation. To avoid unnecessary cesarean section, the mother was administered propranolol hydrochloride orally. The tococardiography became feasible and permitted us to evaluate fetal well-being. The patient successfully delivered transvaginally a male infant at 40 weeks of gestation.

Journal Article↗
PubMed1997

Adenoma malignum: MR imaging and pathologic study.

PURPOSE: To evaluate the clinical, pathologic, and magnetic resonance (MR) imaging findings in adenoma malignum, a rare variant of uterine cervical adenocarcinoma. MATERIALS AND METHODS: Medical records of all patients (n = 7) with adenoma malignum of the uterine cervix diagnosed pathologically between 1988 and 1996 were retrospectively reviewed. Unenhanced T1-weighted and T2-weighted images and gadolinium-enhanced T1-weighted MR images were evaluated, and findings were correlated with gross pathologic and microscopic features. RESULTS: In five of seven patients, enlargement of the cervix was seen. All lesions were detected as multiple cystic lesions that extended from the endocervical gland to the deep stroma of the cervix. They appeared isointense (n = 5) or slightly hyperintense (n = 2) relative to the uterus on T1-weighted images and markedly hyperintense relative to the uterus on T2-weighted images. Solid portions of variable size were seen between cystic lesions, and both the multiple cystic component and the solid portion were most apparent on the gadolinium-enhanced T1-weighted images. Microscopic parametrial invasion was seen in two patients but was not detected at MR imaging. CONCLUSION: Adenoma malignum was depicted on MR images as a multicystic mass with solid portions located in the deep cervical stroma. Gadolinium enhancement helped identify the solid portion of the tumor.

Adenocarcinoma↗
PubMed1988

[Reduced operation for cervical carcinoma and its evaluation].

Cervical carcinoma is usually treated by extensive total hysterectomy such as Okabayashi's procedure. However, since the introduction of the criteria for classification of stage Ia lesions in 1978 by the Registration Committee for Cervical Carcinoma of the Japan Association of Obstetrics and Gynecology, surgical procedures have been categorized in greater detail, and reduced operations have begun to be performed. Generally, simple hysterectomy is performed for stage 0 cervical carcinoma, and semi-extensive hysterectomy is indicated for stage Ia lesions. In this study, reduced operations were evaluated in 254 patients with stage 0 and 288 with stage Ia cervical carcinoma selected from 1,412 patients with cervical carcinoma treated at our department between 1976 and 1985. The time required for the operation was 90.8 +/- 34.8 min for simple, 126.7 +/- 36.5 min for semi-extensive, and 173.5 +/- 42.5 min for extensive hysterectomy. The volume of bleeding was 274.5 +/- 257.7 ml for simple, 545.4 +/- 758.2 ml for semi-extensive, and 805.7 +/- 441.6 ml for extensive hysterectomy. The frequency of blood transfusion increased with the increase in the extent of surgery, being 9.0, 22.9, and 61.8% for the respective operations. The incidence of postoperative complications (cystoplegia, renal disorders, fistula of the urinary tract, ileus and hepatitis) also increased to 12.4% for semi-extensive and 44.8% for extensive hysterectomy. Simple hysterectomy was sufficient for stage 0 lesions, and side effects associated with this operation were infrequent and mild. Curative conization was performed for 14 patients who expressed a desire to have babies, and no recurrence has been observed to date. Semi-extensive hysterectomy was performed in 77% of stage Ia patients, and extensive and simple operations were performed in 8.0% and 10.4%, respectively. Close histological evaluation and postoperative care were carried out, particularly for patients who underwent simple hysterectomy. All these patients are currently alive without signs of recurrence. Two patients received only curative conization due to their strong desire to have babies and are currently being followed up. Both of these patients showed small degrees of interstitial invasion of less than 2mm.

Adult↗
PubMed1986

[Fundamental and clinical studies on imipenem/cilastatin sodium in the field of obstetrics and gynecology].

Fundamental and clinical studies on imipenem/cilastatin sodium (MK-0787/MK-0791) were carried out and the results obtained were summarized below. The transfer of MK-0787/MK-0791 into female genital organ tissues was found to be satisfactory. The transfer of MK-0787/MK-0791 into umbilical arterial blood, umbilical venous blood and amniotic fluid was relatively good. A dose of 1,000 mg/1,000 mg per day of MK-0787/MK-0791 was given to each of 6 gynecology patients for 5-22 days and satisfactory clinical effect was obtained in 5 patients out of 6 patients. No notable side effects or abnormal laboratory findings were observed except for a moderate in elevation in S-GOT/S-GPT in 1 case.

Adult↗
PubMed1985

[Studies on the management of CIN accompanied by infertility].

We performed cytological examinations on 863 of the 969 patients (89.3%). In the final diagnosis, 4 patients had carcinoma in situ (0.5%) and 1 patient had microinvasive carcinoma (0.1%). Therefore, it is important to perform cytological examinations on infertility out-patient s, and conduct routine cytological examinations when infertility treatment is being continued over long periods. The detection rate for the 18 patients who required detailed examination did not differ between primary and secondary infertility, or with the period of infertility or the factor causing infertility. The follow up after conization should be done carefully, and the patient should be encouraged to become pregnant as early as possible. Unlike fertile women, in infertile women, conization should be performed, even in the case of carcinoma in situ, provided: There is a specialist well-experienced in cytology, colposcopy, and histology; the patient and family are fully satisfied with the physician's explanation; the physician can maintain good contact with the patient and family and continue to provide adequate follow up treatment, and the lesion is in the ectocervix, and the whole lesion can be removed by conization without leaving intact foci.

Adult↗
PubMed1983

[Second-look operations in malignant ovarian cancers].

We have been performing second look operations as a measure to improve the results of ovarian cancer therapy. Remarkable advances have been made recently in anticancer drugs; we have been using such agents in combination with the present method not only after conventional trial laparotomies, but also wherever possible in cases having undergone one year of chemotherapy, especially cases presenting neither subjective nor objective symptoms. Of the cases where a therapeutic effect of the drugs was observed, the patient's life was prolonged whenever all residual tumors could be removed as a result of this method. As none of the tumor markers currently in use has been found to be effective in early detection, the second look operation would seem to be indicated both for early detection of reoccurrence and judgment of therapeutic results.

Female↗
PubMed1983

[Treatment of advanced ovarian cancer with cis-dichlorodiammine platinum (CDDP) as single agent or cddp in combination with adriamycin (ADM)].

Twenty-five patients with advanced ovarian cancer were treated with Cis-dichlorodiammneplatinum (CD-DP) 50 mg/m2 as single agent or CDDP 50 mg/m2 in combination with adriamycin (ADM) 50 mg/m2. Both CDDP and CDDP-ADM combination were administered intravenously. Thirteen patients received CDDP alone and twelve patients received CDDP-ADM combination. The single agent activity of CDDP produced a complete response (CR) of 23.1% and a partial response of 15.4% with an overall response rate of 38.5%. The combination of CDDP and ADM gave a response of 58.3% (CR 25.0%, PR 33.3%). Thus, the combination of CDDP and ADM produced a response rate superior to that of CDDP alone. These clinical findings were supported by our investigation of novel experimental therapies in 7, 12 dimethylbenz (a) anthracene induced rat ovarian cancer.

Adolescent↗
PubMed1982

Squamous cell carcinoma arising from an epidermoid cyst in the ovary of a rat treated with 7,12-dimethylbenz[a]anthracene.

Primary non-teratomatous ovarian squamous cell carcinomas are very rare. A case of rat ovarian squamous cell carcinoma has been found in which the tumor arose from a squamous element in the ovary. Squamous epithelial aggregates were found in the wall of a cyst and on serial section, the cyst was found to be unaccompanied by any teratomatous components and showed a thin squamous epithelial lining with keratinizing debris. On the basis of these findings, it was suggested that the squamous element was a rat ovarian epidermoid cyst from which a squamous cell carcinoma arose, presumably by a direct carcinogenic effect of 7,12-dimethylbenz[a]anthracene.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1981

Development of ovarian tumors experimentally studied in mice by 60Co-ray irradiation.

Female C3H strain mice aged 5 to 6 weeks were exposed to a single dose of 400 Rad irradiation to their lower abdomens and the morphological changes of their ovaries were observed until 72 weeks after irradiation. The incidence of tumor development increased gradually from 34 weeks after irradiation till 72 weeks, when ovarian tumors were noted in more than 90% of the animals. Three types of ovarian tumors developed after a prolonged period, postirradiation: tubular adenoma, granulosa cell tumor and luteinizing tumor. Mixed tumor types account for 68% of the tissue examined. The tubular adenoma is believed to arise from the germinal epithelial inclusion cyst, the granulosa cell tumor and luteinizing cell tumor arise from the interstitial cells. In the case of the granulosa cell tumor, it is believed that tumor cells one capable of secreting estrogen, because vaginal smears demonstrated estrus and histological sections of endometrium demonstrated hypertrophy.

Adenoma↗