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Biomedical subjects

A Tudor

Publications and source records attributed to A Tudor.

14 recordsLinked to original sources
PubMed1999

Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease.

We report a pair of monozygotic Huntington's disease (HD) twins who, although sharing identical CAG repeat lengths, not only present with marked differences in clinical symptoms but also behavioral abilities as measured by our experimental procedures. Both HD twins and two healthy control subjects were tested twice over 2 years. Patient A was generally more impaired at a motor level, whereas Patient B showed greater attentional impairment; Patient B, however, showed more progressive deterioration. The control subjects' performance remained consistent over the 2-year interval. Patient A clinically had the more hyperkinetic hypotonic variant of the disease, whereas Patient B, who was the more impaired, presented with a more hypokinetic hypertonic (rigid) variant. The influences of epigenetic pre- and postnatal environmental factors should not be ignored.

Adult↗
PubMed1997

Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.

The translation initiation factor eIF4E is a novel protooncogene found over expressed in most breast carcinomas (Kerekatte et al., 1995), but the pathology where this elevation is initially manifested and its possible role in cancer progression are unknown. We report that eIF4E is markedly increased in vascularized malignant ductules of invasive carcinomas, whereas necrotic and avascular ductal carcinomas in situ display significantly lower levels. eIF4E facilitates the synthesis of FGF-2, a powerful tumor angiogenic factor. Conversely, reducing eIF4E with antisense RNA in MDA-435 cells suppresses their tumorigenic and angiogenic properties, consistent with loss of FGF-2 synthesis. These findings suggest a causal role for eIF4E in tumor vascularization.

Animals↗
PubMed1991

Fourier transform-Raman spectroscopy for the qualitative and quantitative characterization of sulfasalazine-containing polymeric microspheres.

FT-Raman spectroscopy (FTRS) has been used to characterize microspheres produced from the pharmaceutical polymer Eudragit RS containing a range of concentrations of the drug sulfasalazine. While pure sulfasalazine produced an intense and complex Raman spectrum, the spectrum of drug-free Eudragit RS microspheres was considerably weaker in intensity and contained only a few prominent Raman scattering peaks. In spectra of the drug-polymer microspheres, peaks arising from the individual components could be identified. This enabled a quantitative analysis to be undertaken by calculating the ratio between the area of a sulfasalazine peak and the area of a Eudragit RS peak for each microsphere spectrum. A correlation was shown between the peak area ratio and the microsphere sulfasalazine content. FTRS was then applied to a series of microsphere samples which had been dissoluted into pH 7 buffer for 1, 3, 6, 9, 12, or 24 hr. For each spectrum, the drug-polymer peak area ratio was determined and this in turn enabled calculation of the residual drug content of the microsphere sample. FTRS-calculated data showed good agreement with microsphere drug content values determined spectrophotometrically.

Acrylic Resins↗
PubMed1983

[Idiopathic recurrent proximal tibiofibular dislocation in adults. 3 cases treated by an original surgical technic].

Three cases of recurrent dislocation of the proximal end of the fibula were seen and treated by an original technique combining a fibulo-tibial screw and the creation of a pseudarthrosis at the upper end of the fibula shaft. The results were satisfactory. The authors have made a review of the literature and found seventeen comparable cases, ten in children and seven in adults. The authors describe the complications which may follow a tibio fibular arthrodesis or resection of the proximal end of the fibula.

Adolescent↗
PubMed1975

[Lumbrical plus syndrome].

A rare case of paradoxical extension of the medius finger - the so-called lumbrical plus finger syndrome-is described. At operation was found a fibrous adherence of the third lumbrical at the sheath of the flexor digitorum profundus. Some of pathological mechanisms are discussed. A satisfactory result was obtained after the resection of the tendon of the second lumbrical.

Adult↗
PubMedDate not supplied

[Intestinal obstruction caused by abdominal pseudotumoral endometriosis mimicking a peritoneal carcinomatosis--case report].

A 40-year-old woman was admitted in emergency condition with the symptomatology of bowel obstruction. Intraoperative findings consists of a pelvic fixed tumoral mass, and numerous other tumors spread in the whole abdominal cavity mimicking a peritoneal carcinomatosis without liver metastases. Three of the tumors where about 4 cm in diameter producing stenosis of the terminal ileurn and sigma. We considered the case as it was a peritoneal carcinomatosis caused by an uterus or ovarian cancer and we decided for palliative surgery, performing ileo-transversostomy and sigmoidostomy above the obstruction. The histopathologic findings from more pieces of tumors revealed endometriosis without cancerous changes. Postoperative the patient underwent cytostatic and then hormonal therapy. After 3 month the CT scan revealed an important reducing in volume of the pelvic tumoral mass and the barium enema didn't showed any stenosis under the colostomy so, we closed it extraperitonealy. At 16 month after the first operation the patient was reoperated for a parietal defect. At the second look we found no tumors. The pelvic tumoral mass has disappeared, the uterus seemed to be normal but two big ovary cysts were present. We performed bilateral adnexectomy and the repair of the parietal defect. Postoperative evolution was favorable without any complication or complains at 3 month after the last operation.

Adult↗
PubMedDate not supplied

Correlation of serum interferon with some clinical and humoral signs of systemic lupus erythematosus.

The serum level of total interferon (IFN) was measured in 15 male patients with systemic lupus erythematosus (SLE) in the active phase and in remission, before and during corticotherapy. The values found were correlated with the clinical and humoral signs of disease. The IFN titer was high in the active phase of disease and was correlated with fever, extension of skin rash, polyarthritis, myositis, autoimmune hemolysis, cardiac and cerebral involvement as well as with ESR, reacting protein C, CIC, ANF and the percentage of LE cells. Isolated LE nephropathy without rapidly progressive or advanced renal failure was not associated with high IFN titer.

Adult↗
PubMedDate not supplied

Pulmonary involvement in systemic lupus erythematosus.

In the course of an ample study of collagen diseases carried out in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest over a long period, a group of 608 patients with systemic lupus erythematosus (SLE) hospitalized between 1974 and 1986 formed the object of the present study. Of these patients 18% presented pulmonary alterations due to SLE and 3.9% lung diseases of other etiology. The types of pulmonary involvement due to SLE were: pleurisy, interstitial pneumonia, diaphragmatic myopathy. Latent pulmonary damage could also be diagnosed in 8 patients. Most of the patients (94.1%) were females and had been hospitalized several times. Concomitantly with pulmonary damage other organ involvements have also been observed. Complex investigation of respiratory function performed in a selected group of patients revealed: restrictive syndrome, decrease of the gas transfer factor, increase of elastic recoil, hypoxemia on exercise. In most of the cases (92%) the pulmonary diseases had a chronic evolution. The treatment used was corticosteroids in 60% of the cases investigated.

Adolescent↗
PubMedDate not supplied

Study of respiratory and immunologic changes in the workers of a poultry farm.

The present investigation was designed to the study of respiratory symptoms and immunologic changes in workers of a poultry farm, chronically exposed to various organic allergens (avian, fungi, etc.). The group studied included 202 exposed subjects (109 at the slaughter house, 93 on the farms) and 100 controls. Although the group was chiefly made up of young women, non-smokers, exposure to avian allergens increased the prevalence of respiratory symptoms. Thus, coughing and expectoration was noted in 8.2% of the workers in the slaughter house and 10.7% of those on the farms, wheezing being present especially in the latter (13.9%). An apparently obstructive pulmonary function was observed in 16.10% of the farm hands and 1% of controls. The study of humoral immunity suggested that the presence of precipitation antibodies (76% positive reactions in the farms, 63% in the slaughter house, 44% among the controls) indicated exposure to avian allergens rather than the clinical and radiologic presence of the disease.

Abattoirs↗