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Biomedical subjects

A V Arakelian

Publications and source records attributed to A V Arakelian.

4 recordsLinked to original sources

[The surface membrane potential in a fluctuating medium].

Fluctuations of the surface membrane potential due to adsorbtion and desorbtion of ions when environmental fluctuations generate a fluctuation in the number of adsorbtion sites were investigated. The correlation functions of surface charge density, surface potential and the spectral density of surface potential fluctuations were calculated. The characteristic features of these fluctuations were determined.

Adsorption↗

[Study of complexes of ethidium bromide with DNA by differential pulse voltammetry].

The interaction of ethidium bromide with calf thymus DNA was investigated by the method of differential pulse voltammetry. It was found that ethidium bromide binds with DNA in several ways. Corresponding values of the constants and the number of binding sites were determined. The intercalation, semi-intercalation, and electrostatic mechanisms of interaction were shown. The results obtained are in good agreement with the data obtained by spectroscopic (absorption and fluorimetric) methods.

Animals↗

[Kinetics of ligand binding to nucleic acids at random fillings].

Ligand binding with nucleic acids is described in frames of the theory of random processes. It is shown that the probabilistic description of binding of a ligand to nucleic acid allows one to describe not only the kinetics of changes in the number of bound ligands at arbitrary fillings but also to calculate stationary values of the number of bound ligands and its dispersion. A general analysis of absorption isotherms and the kinetics of ligand binding with nucleic acids allows one to determine the rate constants of formation and decomposition of the ligand-nucleic acid complex. A comparison of the results obtained with the case of low fillings is conducted.

Kinetics↗