[Foreign body of the stomach simulating wide pedunculated polyp].
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Biomedical subjects
Publications and source records attributed to A V Arakelian.
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Fluctuations of the surface membrane potential due to adsorbtion and desorbtion of ions when environmental fluctuations generate a fluctuation in the number of adsorbtion sites were investigated. The correlation functions of surface charge density, surface potential and the spectral density of surface potential fluctuations were calculated. The characteristic features of these fluctuations were determined.
The interaction of ethidium bromide with calf thymus DNA was investigated by the method of differential pulse voltammetry. It was found that ethidium bromide binds with DNA in several ways. Corresponding values of the constants and the number of binding sites were determined. The intercalation, semi-intercalation, and electrostatic mechanisms of interaction were shown. The results obtained are in good agreement with the data obtained by spectroscopic (absorption and fluorimetric) methods.
Ligand binding with nucleic acids is described in frames of the theory of random processes. It is shown that the probabilistic description of binding of a ligand to nucleic acid allows one to describe not only the kinetics of changes in the number of bound ligands at arbitrary fillings but also to calculate stationary values of the number of bound ligands and its dispersion. A general analysis of absorption isotherms and the kinetics of ligand binding with nucleic acids allows one to determine the rate constants of formation and decomposition of the ligand-nucleic acid complex. A comparison of the results obtained with the case of low fillings is conducted.