PubMed Health⌕ Search

Biomedical subjects

A V Beliakov

Publications and source records attributed to A V Beliakov.

10 recordsLinked to original sources
PubMed1992

[Use of laser irradiation for the prevention and treatment of complications following surgery of the lungs and pleura].

Low-energy laser irradiation was used in treatment of 77 patients with surgical diseases of the lung and pleura. Laser therapy was performed by means of transcutaneous irradiation of the patients with the use of a semiconductor arsenide-gallium laser and influencing with helium-neon laser on the biologically active points. The use of laser therapy contributed to decrease in incidence of postoperative complications, shortening the duration of treatment of the patients at a hospital.

Adult↗
PubMed1985

[Adaptation to neuroleptic preparations and several ways of combatting it (experimental study)].

To study the possible mechanisms of the formation of secondary therapeutic resistance, the author carried out a chronic experiment on animals which were administered different doses of a neuroleptic (haloperidol) for 20 days. The neuroleptic effect of the drug was shown to significantly decrease following prolonged administration. It was found that upon the first administration of haloperidol mice developed marked catalepsy 2 hours after administration. In conditions of a prolonged administration of the drug its cataleptogenic action was observed to diminish by the 20th day. Diminution of catalepsy was explained by a decrease of the blocking effect of the neuroleptic on the dopamine system. Change in the function of dopamine receptors (zigzag administration of haloperidol or administration of the drug simultaneously with apomorphine) was found to restore the cataleptogenic properties of the neuroleptic. The data obtained were used in the treatment of 47 patients with paranoid schizophrenia who developed resistance to pharmacotherapy.

Animals↗
PubMed1984

[Various methods of overcoming secondary resistance to treatment developing in relation to adaptation to psychotropic drugs during long-term treatment (clinico-experimental study)].

Clinical and experimental studies into the phenomenon of adaptation to neuroleptic agents and into the methods of its overcoming were carried out. An experimental study of the long-term administrations of haloperidol revealed the formation of adaptation to the drug which can be overcome by a zigzag-like sharp elevation of the dosage followed by rapid reduction to the baseline level. The trial of this method under clinical conditions showed that it was expedient to use on a large scale the experimental findings on the specific features of the formation and prevention of the secondary therapeutic resistance.

Adult↗
PubMedDate not supplied

[Effect of varying the dose of haloperidol during its prolonged administration on the development of tolerance and hypersensitivity in dopamine receptors].

It has been shown in experiments on male mice that prolonged administration (for 20 days) of haloperidol in doses of 0.1, 1.0, 5.0 and 10.00 mg/kg produced an increase in the tolerance to thecataleptogenic effect at the end of administration and a rise in 3H-spiroperidole binding with striatum membranes on the 5th day after discontinuation of the neuroleptic, which attests to an increase in the sensitivity of dopamine receptors. Variation of haloperidol dose every other three days during 20 days of drug administration (1.0--0.1 ... 1.0 mg/kg and 1.0--10.00 ... 1.0 mg/kg) eliminated the manifestations of tolerance and hypersensitivity of dopamine receptors. It is assumed that variation of the neuroleptic dose during prolonged administration prevents the development of extrapyramidal disorders of the hyperkinetic type.

Animals↗