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Biomedical subjects

A V Cichelli

Publications and source records attributed to A V Cichelli.

5 recordsLinked to original sources

Pulmonary infiltrates associated with Vibrio vulnificus septicemia.

In the case described, fatal Vibrio vulnificus primary septicemia was complicated by development of diffuse pulmonary infiltrates. Clinical features of this recently discovered infectious disease are discussed. Various aspects of diagnoses of pulmonary infiltrates in patients with V vulnificus septicemia are also presented. Vibriosis should be suspected in patients with chronic, underlying, predisposing diseases, recent ingestion of raw seafood, and characteristic skin lesions.

Humans

Reactive airway dysfunction syndrome in three police officers following a roadside chemical spill.

The reactive airway dysfunction syndrome (RADS) is a recently described syndrome in which bronchial hyperreactivity and asthmatic symptoms develop in previously healthy individuals after a single large exposure to an irritating gas, fume, or vapor. We report a cluster of three Philadelphia police officers who developed RADS after a common exposure to toxic fumes from a roadside truck accident. Results of initial pulmonary function testing were normal in all three, and methacholine challenge was required for diagnosis in two out of the three. This syndrome needs to be recognized by physicians dealing with environmental or industrial medicine as a potential cause of loss of work or inability to perform on the job. Also, there is a potential for multiple individuals to develop this syndrome from a single incident.

Accidents, Traffic

Sarcoma of the pulmonary artery.

A patient is described in whom clinical presentation, V/Q scan, and pulmonary angiogram were consistent with pulmonary embolus. No improvement occurred despite therapy with heparin. When sent for surgical embolectomy, sarcoma of the pulmonary artery was diagnosed. This entity, though rare, should be considered in the differential diagnosis of pulmonary vascular disease.

Diagnosis, Differential

Angiosarcoma presenting as diffuse alveolar hemorrhage.

Angiosarcoma has been reported as occurring in both postirradiation and postradical mastectomy patients. Described is a patient, postmastectomy and irradiation, with alveolar hemorrhage secondary to angiosarcoma. Angiosarcoma, primary or metastatic to lung, should be included in the differential diagnosis of diffuse alveolar hemorrhage in this patient population.

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