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Biomedical subjects

A V Epishin

Publications and source records attributed to A V Epishin.

At least 19 recordsLinked to original sources
PubMed1992

[The incidence and nature of hepatobiliary system diseases in workers of the Ternopol Clothing Association].

A detailed clinico-laboratory examination of workers of Ternopol sewing factories revealed in 13.9% chronic inflammatory diseases of the hepatobiliary system which exceeds 4 times the indices of seeking medical advice (3.5%) mainly due to latent course. Entropy of blood serum protein data are more informative than bilirubin and transaminase data used in evolution of homeostasis disorders in these patients.

Adult↗
PubMed1991

[The blood coagulation status and the immunochemical and clinical indices in patients with active rheumatism during treatment with nerobol].

Blood coagulation, immunobiochemical, and clinical characteristics were studied in patients with rheumatic fever running a protracted course treated by combined therapy including nerobol. To assess the therapeutic efficacy of nerobol, the patients were divided into 2 groups: Group 1 (30 patients) were administered combined antirheumatic therapy, Group 2 (30 patients) were administered the same + nerobol in a daily dose of 15 mg for 3-4 weeks. The findings evidence a positive effect of the drug on the status of patients in whom rheumatic fever runs a protracted course: blood procoagulative activity is reduced and anticoagulative activity elevated, blood immunobiochemical and clinical characteristics normalized.

Adolescent↗
PubMed1991

[Infectious-toxic shock in patients with acute pneumonia].

An analysis of case records, medical documentation of the emergency service and out-patient departments of 629 patients with acute pneumonia (AP) showed that infectious-toxic shock was an early grave complication of acute pneumonia. It was observed in 9.4% of patients with acute pneumonia and resulted in a fatal outcome in 5.1%. Infectious-toxic shock developed prevalently in males of young or middle age suffering of concomitant diseases in acute pneumonia due to viral-bacterial associations. At the pre-hospital period shock was detected only in 5.1% of patients due to inadequate examination, underestimation of symptoms and their erroneous interpretation. Clinical manifestations of infectious-toxic shock, their polymorphism may masquerade acute pneumonia symptoms and lead to diagnostic errors.

Acute Disease↗
PubMed1991

[Immunologic disorders in patients with primary hypothyroidism].

Most patients with primary hypothyroidism showed changes in the immune status manifested in a reduction of the number and functional activity of T-lymphocytes, increased sensibilization of lymphoid cells to thyreoglobulin, content of B-lymphocytes, serum immunoglobulins of M, G classes, antithyreoglobin antibody titer and circulating immune complexes. The frequency and grade of immune disorders are directly related to the severity of the disease. The most pronounced changes were revealed in spontaneous hypothyroidism.

Adolescent↗
PubMed1991

[Immunoactive drugs in the combined modality therapy of patients with hypothyroidism].

Comparative studies into the clinico-immunologic status of patient with primary hypothyrosis have shown that the multimodality treatment including differentiated administration of immunoactive agents (glucocorticoids, splenin) promoted more well-defined normalization of cellular, humoral immunity and nonspecific defence as well as reduction or disappearance of the clinical disease manifestations as compared to patients who did not receive those drugs as part of the multimodality therapy. The use of glucocorticoids and splenin may be recommended as part of the multimodality treatment of patients suffering from primary hypothyrosis marked by pronounced disorders in the immune system.

Adjuvants, Immunologic↗
PubMed1990

[The importance of the complement consumption reaction for the differential diagnosis of diseases of the hepatobiliary system].

A study is presented of 94 patients with chronic inflammatory diseases of the hepatobiliary system and in 22 patients with dyskinesia of the biliary tract. The importance of the complement consumption reaction was evaluated (N. I. Kondrashova modification). The results of the investigation revealed distinct increase of the level of antitissue antibodies in patients with chronic inflammatory diseases of the hepatobiliary system at the stage of exacerbation. This may be used for assessment of the activity of the pathological process, differential diagnosis of biliary tract dyskinesia and as an index of treatment efficacy.

Adolescent↗
PubMed1989

[Significance of immunologic tests in the evaluation of treatment results in subacute thyroiditis].

The authors suggest that the prognosis of subacute thyroiditis may be based after treatment on the immunity state. It was revealed that T- and B-lymphocyte as well as nonspecific defence disorders in treated patients with subacute thyroiditis promote more frequent recurrences or hypothyrosis and autoimmune thyroiditis in comparison with patients whose immunity was slightly involved or not involved at all.

Adult↗
PubMed1989

[The effect of mercasolyl on immunologic indicators in patients with diffuse toxic goiter].

A study of system of cellular and humoral immunity, unspecific defense in 187 patients with diffuse toxic goiter before and after treatment with mercasolyl revealed that despite the clinical effect, the agent did not essentially influence the content and functional activity of T-lymphocytes. The effect was more favourable on the content of immunoglobulins, titer of antithyroid antibodies. This was observed in mild and average severe course of the disease. It is suggested that mercasolyl effects lymphocytes synthesizing autoantibodies to the thyroid gland.

Adult↗
PubMed1989

[Effect of glucocorticoids on immunological indices in patients with subacute thyroiditis].

Use of glucocorticoid agents in 110 patients with subacute thyroiditis furthered normalization of the cellular, humoral immunity and unspecific defense factors. Clinical signs of the disease disappeared quicker than reduction of the severity of immune and autoimmune disorders evidencing protraction of the disease and necessity of prophylactic treatment and use of additional immunoregulating agents.

Adolescent↗