PubMed Health⌕ Search

Biomedical subjects

A V Frolov

Publications and source records attributed to A V Frolov.

At least 19 recordsLinked to original sources
PubMed2004

[Novel functional stress test (stochastic) and perspectives of its application].

AIM: To assess advantages of a stochastic functional stress test during which workloads change according to law of random numbers. METHOD: Results of stochastic tests and standard stress tests with stepwise increments of workloads were compared in 45 healthy subjects and 90 patients with ischemic heart disease (45 with angina pectoris, 45 after myocardial infarction). RESULTS: Compared with standard tests stochastic test was characterized by shorter times of achievement of ischemic threshold and higher double product. Sensitivity and specificity of stochastic test were significantly better than those of standard stress test. The difference between results of two tests can be explained by increased information content of the stochastic test.

Chronic Disease↗
PubMed2004

[Psychoemotional stress tests and prospects for their use in cardiology].

Social and economic transformations of the society enable to suggest an ever increasing role of psychoemotional factors in the development of cardiovascular pathology. The paper contains a review of psychoemotional functional stress tests (arithmetic, speech, information, computer games). Stroop-testing method, which over the recent half of a century has been acknowledged as < >, is described in detail. Criteria for assessment of psychoemotional stress tests, including ECG and blood pressure dynamics, echocardiography, heart rate variability etc., are also described. Method for quantitative evaluation of effectiveness of psychoemotional Stroop-testing from the positions of information theory is suggested. The method is based on correlations between physiological response and flow of information being processed (bit/s).

Blood Pressure↗
PubMed2004

[A renoprotective effect of enalapril in chronic transplantation nephropathy].

AIM: To study safety and efficacy of ACE inhibitor enalapril in chronic transplantation nephropathy (CTN) as well as nephroprotective efficacy of this drug in various clinical variants of CTN. MATERIAL AND METHODS: A retrospective study covered 220 recipients with CRF. The patients were divided into the study group (n = 103) and the control group (n = 117). The study group was given ACE inhibitor enalapril the efficacy of which was assessed by arterial pressure (systolic, diastolic, mean) dynamics, 24 h proteinuria and the rate of CTN progression. This rate was suggested by probability of plasm creatinin doubling (Kaplan-Meier technique). RESULTS: Enalapril significantly inhibited CTN progression running with minimal or marked proteinuria, had a pronounced hypotensive effect, promoted stabilization of minimal proteinuria (in CTN with minimal proteinuria) or reduction of protein excretion (in a proteinuric variant of CTN). CONCLUSION: Use of enalapril in CTN in a daily dose 10 mg maximum is safe and can be used for inhibition of CTN progression.

Adolescent↗
PubMed2002

[Modification of clinical classification of heart failure with quantitative evaluation of functional state].

Definite dissociation exists between severity of clinical symptoms of heart failure and degree of cardiac dysfunction. Comparative analysis of existing heart failure classifications reveals low degree of congruence in evaluation of patient's state by different experts. This disagreement is mainly caused by limited number of gradations in NYHA classification and descriptive character of information. That is why supplementation of current classification with quantitative assessment of functional state by means of introduction of precise and easily obtainable statements is required. A modification of 6 min walk test is suggested for this purpose. The paper contains methodology of the test and calculations necessary for assessment of working capacity (in joules) and intensity of work (in watts). Possibility of evaluation of results of cardiovascular surgery is especially stressed.

Disability Evaluation↗
PubMed2002

[Some results and perspectives of heart failure research].

Heart failure is a frequent often in the practice of a cardiologist but data on its actual incidence are inconsistent. This can be explained by variations in methodological approaches. Screening studies require simple easily obtainable and safe techniques capable to characterize activity of a patient. Their results should be compatible with widely accepted NYHA classification. Six minute walking test is one of possible solutions. Its results agree with NYHA classes, peak oxygen consumption and prognosis of survival. For improvement of accuracy of estimation of physical working capacity it is important to consider body mass. This can be achieved by a simple portable device constructed by the authors. To assess sufficiency of circulation during testing it is advisable to determine the load at which decorreleation between dynamics of effort and that of physiological parameters is revealed. Basing on the above considerations the authors suggest to define heart failure as a condition when decorrelation of physiological functions causes deterioration of perfusion and worsening of quality of life.

Heart Failure↗
PubMed1996

[The transformation of acute viral hepatitis B into chronic].

500 patients with hepatitis B have been followed up from the acute onset to long-term outcome. As for chronic transformation of the disease, at higher risk are patients with mild form, progredient run and inadequate immune response. Of the highest value for identification and prognostication was a dynamic quantitative control over the system HBeAg-anti-HBe providing separate prognosis of establishment of replicative or integrative variants of chronic hepatitis B. In progredient infection an early administration of reaferon in combination with thymogen is thought valid which in many patients is sufficient to prevent the disease transformation into a chronic form.

Acute Disease↗
PubMed1992

Stable cupola-shaped bilayer lipid membranes with mobile Plateau-Gibbs border: expansion-shrinkage of membrane due to thermal transitions.

Stable bilayer lipid membranes (BLM) with mobile Plateau-Gibbs border (PGB) have been formed. The precondition of the formation was the presence of a lipid coverage on the teflon surface near the hole, where the membrane has been formed. This allowed the movement of the PGB along the teflon surface after transformation of the planar bilayer into a cupola-shaped by bowing of the bilayer due to excess hydrostatic pressure. As a result the giant bilayers were obtained with an area up to two orders larger in magnitude compared with the initial area. Changes in lipid bilayer area depend on the temperature at the phase transition of the lipid. Cooling of the expanded bilayer was followed by a significant shrinkage of the bilayer at temperatures below the main phase transition.

Chemical Phenomena↗
PubMed1991

[Use of personal computers for early detection of cardiovascular pathology among industrial workers].

The results are provided on the development and introduction of automated working places on the basis of personal computers for the prevention, follow-up and treatment of patients with arterial hypertension (AH) and ischemic heart disease (IHD) at an industrial enterprise. The process of identifying persons with AH and IHD is automatized. Automated working places on ECG processing, assessment of central and cerebral hemodynamic parameters are introduced. Information load has been developed in the form of a computer game for identifying persons with early stages of AH. A base has been created for storage of the results of regular medical check-ups. The complex has been tested during 2 years in the settings of a health unit at the Lenin tractor plant in Minsk. As a result of comprehensive measures, provisional functional diagnosis expenditures were reduced by 30-70%. Losses due to temporary disability as a result of circulatory diseases were reduced by 26%.

Coronary Disease↗
PubMed1984

[A new psychophysiologic test, "The Information Test", and its possible use in cardiology].

The authors describe a new psychophysiological test based on the use of commercially available television apparatuses and aimed at determining the efficiency of information processing. The use of the test in 346 people has demonstrated its acceptability for building up psychoemotional tension and detecting the hypertensive hemodynamic response. The analysis of the results of the testing conducted in normal subjects and cardiovascular patients has permitted the selection of the most informative criteria of the test. These include the coefficient of information processing, and also the increment and time-course of the blood pressure. This standardized psychophysiological test may be employed in the diagnosis of the early stages of arterial hypertension and neurocirculatory dystonia.

Adolescent↗
PubMedDate not supplied

[Formation of stabile cupola-like lipid bilayer membranes with a mobile plateau Gibbs boundary].

Stable bilayer lipid membrane with mobile Platear-Gibbs border have been formed. The predominant condition of the formation is the presence of lipid coverage on the teflon surface near the hole. The formation process includes transformation of the initial planar lipid bilayer into cupola-shaped one by bowing of the lipid bilayer due to hydrostatic pressure, movement of the PGb along the teflon surface. The bilayer area estimated by electric capacitance increases from 0.1 x 10(-8) F to 21 x 10(-8) F. Electric conductance of the lipid bilayer has not changed except for the phase transition and membrane collapse. The electric capacitance of the BLM formed from hydrogenated egg lecithin was changed by cooling between 60 degrees and 40 degrees C with the maximum at about phase transition range. The individual membrane sustains several scannings of the temperature without disruption which is an evidence of the stability of the cupola-shaped membranes.

Electric Conductivity↗