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Biomedical subjects

A V Kalinin

Publications and source records attributed to A V Kalinin.

At least 19 recordsLinked to original sources
PubMed1994

[Acute and chronic gastroduodenal erosions: characteristics of etiology, pathogenesis, clinical aspects and diagnosis].

Comprehensive investigation of 2620 patients with general somatic diseases revealed acute gastroduodenal erosions in 252 of them and chronic gastroduodenal erosions in 178 patients. Principal differences between clinical, endoscopic and morphological features of those two types of erosion due to etiological and pathogenetic character of their formation were established as the changes in the immune response, disorders in the protein and lipid metabolism. Almost 75% of chronic erosions correlated with circulation disorders, the diseases of hepatobiliary system and were their local morphological equivalents.

Adult↗
PubMed1993

[The clinical picture and diagnosis of pancreatic carcinoma].

A total of 97 patients with pancreatic carcinoma were examined with sonography, computed tomography of the pancreas and endoscopy of the stomach and duodenum. The tumor involved mainly the head of the pancreas in 69 (71.1%), the body in 21 (21.7%) and the tail in 7 (7.2%) patients. Two basic types of the disease were identified: disseminated in 83 patients and rare in 14 patients. The disseminated type included a central (45 patients) and a peripheral (38 patients) variant. The latter is classed as peripheral (n = 30) and paraduodenal (n = 8). The rare types included masked variants (n = 6), miniblastomas (n = 3), megablastomas (n = 2) of the pancreas, as well as thrombotic variants of the disease (n = 3). The highest diagnostic value of sonography and computed tomography was observed in intrinsic peripheral variants of carcinoma. Gastroduodenal endoscopy along with biopsy of suspected segments is highly diagnostic in paraduodenal variants of the disease.

Biopsy, Needle↗
PubMed1993

[The use of the carbohydrate antigen CA-19-9, the carcinoembryonic antigen and alpha fetoprotein in the diagnosis of pancreatic cancer].

Enzyme immunoassay was used to study blood levels of CA-19-9, cancerous embryonal antigen, and alpha-fetoprotein in blood donors (n = 33), patients with chronic pancreatitis (n = 35), those with pancreatic carcinoma with metastases (n = 28), and without them (n = 21). A differential diagnosis was found to be made between healthy individuals and patients with chronic pancreatitis and those with pancreatic carcinoma via determination of the above tumour markers. The presence of hepatic metastases of pancreatic carcinoma may be suspected if the blood levels of the cancerous embryonal antigen and CA-19-9 are over 15 ng/ml and over 600 U/ml. The level of alpha-fetoprotein was higher only in 14.3% of pancreatic carcinoma patients with hepatic metastases. A comprehensive examination of the levels of all three tumor markers allows one to differentiate pancreatic carcinoma and chronic pancreatitis and to determine whether a patient with pancreatic carcinoma is operable.

Adult↗
PubMed1993

[Helicobacter pylori infections in various groups of patients at a general hospital and in blood donors].

Incidence of Helicobacter pylori (HP) infection in inpatients of a general hospital and donors was evaluated immunologically: the serum was examined for IgG antibodies to HP using enzyme immunoassay. Of 354 examinees 89 had duodenal ulcer (DU), 101 were healthy donors. HP infection was found prevalent in all the groups of the inpatients. Cases of HP were more numerous in the gastroenterological department as compared to other departments (81.6% against 39.6%, respectively). Among patients of the gastroenterological department DU patients were most frequent HP carriers (93.2%), this being indicative of a close correlation between DU and HP revealed previously by other diagnostic methods. Rare occurrence of HP in normal subjects (6-11%) reported by many authors was not confirmed, as HP was detected in 33% of the donors. Age-related analysis points to early onset of HP infection (25-26% incidence in 18-20-year-olds), its peak in middle-aged and presenile patients (78-80% in 50-69-year-olds) and lower occurrence in senile patients (25% at the age over 70).

Adolescent↗
PubMed1992

[Diagnostic difficulties and errors in early stomach cancer].

Difficulties that occur in the diagnosis of early gastric carcinoma (EGC) were studied on a material of 1617 prophylactic endoscopic examinations of persons who did not make any complaints of the alimentary organs and 2158 primary gastroscopies performed in accordance with the patients' complaints, results of the dispensary follow-up of 811 patients who made up a risk group, and an analysis of case reports of 183 patients in whom EGC was confirmed by surgery. The authors emphasize a high percentage of errors determined by the lack of the pathognomonic symptomatology, difficulties of interpreting the endoscopic appearance and histologic confirmation of carcinoma. To improve early diagnosis of gastric carcinoma (GC), it is recommended that every endoscopic investigation be performed with oncological apprehension, paying attention even to the minimum focal changes in the gastric mucosa and making spot biopsy of those changes. It is also advisable that a more strict approach should be exercised to the formation of risk groups, restricting them to the patients at greater risk for GC or with unrecognized GC (first revealed and poorly healing ulcers, polyps measuring over 2 cm in diameter, grade III dysplasia discovered in gastric biopsy specimens). Such patients should be placed under dispensary observation including endoscopy which is to be made in the first stage after 1, 3 and 6 months.

Adult↗
PubMed1992

[The outpatient treatment possibilities for patients with exacerbated peptic ulcer].

The efficacy of hospital and ambulatory treatment of patients with peptic ulcer exacerbation was compared. 209 patients were treated in the hospital and 116 on an ambulatory basis. No appreciable differences were found in the times of the removal of the painful syndrome or gastroduodenal ulcer healing. At the same time early relapses were recorded in 26.4% of the inpatients and in 14.9% of the outpatients. Indications for the treatment of outpatients with gastroduodenal ulcers were developed: rare relapses, lack of complications, moderate painful syndrome, small ulcer dimensions, a possibility of arranging good treatment and control over ulcer healing, favourable living conditions, and being in a positive mood for outpatient treatment.

Ambulatory Care↗
PubMed1991

[Erosive changes of the gastroduodenal mucosa--is it a pre-ulcer state?].

The evidence obtained on 280 ulcer patients, 107 of whom have preulcer erosive gastritis, duodenitis or gastroduodenitis, suggest the conclusion on ulcerogenesis dependence on the type and site of erosions, response of blood germs, characteristics of protein, carbohydrate and electrolyte metabolism. Erosive processes in the gastroduodenal mucosa seem a facultative preulcer state.

Duodenitis↗
PubMed1991

[The characteristics of the internal picture of the disease in patients with endogenous psychoses and peptic ulcer].

The studies which were conducted at a group of patients with endogenic psychosis and ulcer of stomach or duodenum have shown that the internal course of ulcer diseases might camouflage for a long period the existence of mental illness that would negatively influence upon the treatment of such patients. In particular these are the cases of continuous sluggish schizophrenia and affective psychosis. All the patients with inadequate course of somatic illness need psychiatric consultation in order to prove the absence of mental illness and choose an adequate medical tactics.

Bipolar Disorder↗