[Effects of the drug magne B6 on the trace element homeostasis of rat brain].
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Animals↗
Biomedical subjects
A V Kudrin
Publications and source records attributed to A V Kudrin.
Trace elements in regulation of NF-kappaB activity.
In recent years several studies have shown that NF-kappaB might be a very important therapeutic target in the treatment ot various chronic inflammatory, degenerative and tumour diseases. Trace elements play essential roles in the regulation ot cell signaling mechanisms via transcription tactors and a large number of genes. An important aspect of the present review is the description ot the mechanisms by which trace elements might influence transcription factor NF-kappaB. DNA-binding activity of NF-kappaB is regulated by the redox state of the cysteine residue (Gys-62) in the DNA binding domain of the p50 subunit and impaired by different metals (Go, Cr, Ni, Cd, Pb). It has been hypothesised that the broad speciticity of interrelationships between NF-kappaB. AP-1 and various metals results from interactions of metals with specific moieties of transcription factors and IkappaB-kinases, as well as trom the existence of a metal-governed redox system. The hypothetical targets in the NF-kappaB signaling pathway affected by metals are: IkappaB-kinases, IkappaBs, NF-kappaB, proteasome degradation of NF-kappaB, kappaB-sites in DNA. Possibly, this system is required by the cell for adequate regulation ot the transcription machinery in response to changes in intracellular and intranuclear fluxes of metals and radicals and is very ancient evolutionary mechanism of stress adaptation. The role of the NF-kappaB-mediated mechanism in induction or prevention of chronic intlammatory, allergic, degenerative and tumor diseases by zinc, vanadium, manganese, copper, silica, iodine and other trace elements is discussed.
Animals↗
[Hospitalization for morbidity with respiratory diseases in residents of an industrial city].
In view of the growth of adverse epidemiological indices for respiratory diseases (RD) in Russia, studies are warranted to get insights into regularities of their dynamics in a large industrial urban centre. A paradoxical decline is shown in the level of RD morbidity, caused by economical problems of health care with the growing need for hospitalization still in place, as exemplified by the situation in Orenburg. Of a serious concern to us is also an increasing latent RD morbidity resulting in disability of patients.
Hospitalization↗
[Trace elements and natural killer activity].
Each cell of human body contains from 10(5) to 10(6) ions of different trace elements which may perform the important functions of regulation of cell metabolic system activity, genomic apparatus. However, the problem of trace elements influence on immune response, cytokine system, expression of components of the major histocompatibility complex and natural killer (NK) activity is not well studied. Some trace elements (Li, Zn, Mg, Se, Ge, Fe, etc.) show their effect on the level of intracellular messenger systems, inducing the production and potentiating the action of the great number of cell cytokines stimulating NK. Immune cytokines provide efficiency of NK-lysis and promote the decrease of tumor cell resistance to it. Interactions of trace elements and antitumor immunity is a perspective field of investigation.
Humans↗
[General pathology of trace element deficiency].
According to the authors' concept, different forms of trace element deficiency show some general rules of development. All of them are followed by a decrease of immune resistance. Trace element deficiency is never isolated, it is always characterized by trace element unbalance and is followed by a considerable disturbance of metabolism (mineral, lipid, carbohydrate and protein) with relevant manifestations. Reduced immune resistance and pluriglandular endocrinopathy create the conditions for various malignancies.
Anemia, Iron-Deficiency↗