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Biomedical subjects

A V Lipnitskiĭ

Publications and source records attributed to A V Lipnitskiĭ.

16 recordsLinked to original sources
PubMedDate not supplied

[The effect of heterologous bacilli on the infectious process in anthrax in an experiment].

The possibility of the survival of guinea pigs after the simultaneous administration of different doses of Bacillus anthracis virulent strain 81/1 in combination with both B. anthracis vaccine strain STI and heterologous bacilli (B. subtilis strain PAC) has been experimentally shown. On the basis of the results of these experiments suggestion has been made that the "survival phenomenon" is the process involving the lysosomal systems of polymorphonuclear and mononuclear phagocytes.

Animals↗
PubMedDate not supplied

[Induction of Bacillus anthracis hemolytic activity with the use of Myxococcus xanthus].

The development of a new method for the induction of the B. anthracis hemolytic activity with the use of M. xanthus and the differentiation of pure cultures of the causative agent of anthrax from those contaminated with myxobacteria is presented. To demonstrate the induction of the hemolytic acivity of B. anthracis with the use of M. xanthus, conditions for the symbiosis of B. anthracis cells STI, exhibiting no hemolytic activity, with M. xanthus non-hemolytic cells were created by mixing them and inoculating the symbiotic biomass on the surface of blood agar.

Agar↗
PubMedDate not supplied

[Venezuelan equine encephalitis: state-of-the-art].

The paper provides the currently available data on the global prevalence of Venezuelan equine encephalitis (VEE), its epidemiology, clinical picture, and specific prevention in human beings. It also discussed the problem of potential use of the causative agent of VEE as a subject of bioterrorism.

Americas↗
PubMedDate not supplied

[Dimorphism in the fungus Coccidioides immitis Rixford et Gilchrist under the action of saprophytic bacilli].

It is shown that there are specific substances produced and secreted into the environment by saprotrophic bacilli. These inhibit the growth of the coccidioidal fungus in its mycelial form and some cells are converted into the yeast form, which leads to the destruction of the fungi (in natural environment) or, if the conditions allow, to their growth in the yeast form. This phenomenon, existence of a large amount of bacilli antagonistic to Coccidioides immitis, may be one of reasons why the latter has not been isolated so far from the soil in the territory of the USSR.

Antibiosis↗
PubMedDate not supplied

[A species-specific DNA probe for identifying toxic strains of anthrax pathogens].

On the plasmid DNA pOX01 of the anthrax pathogen two BamHI fragments were localized which facilitate detection of the Bacillus anthracis strains carrying pXO1 replicon. These fragments, after complete hydrolysis of plasmid DNA by HindIII, were cloned on the vector plasmids pUC19 and pBR322 by the "shot-gun" method in Escherichia coli cells. It is shown that the 900 bp BamHI/HindIII fragment from the pZAT1 recombinant plasmid has an ability for specific hybridization with DNA of toxigenic strains of B. anthracis and could be used as species-specific anthracic DNA probe which identifies toxigenic strains of the anthrax pathogen differentiating it from the other species of Bacillus genus as well as from the bacteria of other taxonomy groups.

Bacillus anthracis↗
PubMedDate not supplied

[The characteristics of the interaction of Bacillus anthracis with host phagocytes in relation to the plasmid spectrum of the causative agent].

The study revealed that after the intraperitoneal inoculation of spores of B. anthracis strains with different plasmid composition into guinea pigs the active germination of the spores both outside and inside the cells of the host occurred as early as on hour 2 of their interaction with the macroorganism. The further fate of the infective agent and the character of its interaction with peritoneal exudate cells depended on the plasmid composition of the bacilli. Thus, the presence of toxin-formation plasmid PXO1 and capsule-formation plasmid PXO2 in B. anthracis permitted the successful adaptation of these bacilli to the conditions of the macroorganism, while the absence of such plasmids made them nonviable in this environment. The presence of plasmid PXO1 in B. anthracis permitted the manifestation of their cytopathic effort on the cells and the presence of plasmid PXO2 only gave the bacilli incomplete protection from phagocytosis.

Animals↗