Biomedical subjects
Publications and source records attributed to A V Makrushin.
A problem is discussed about origin of the mechanism of old age involution. A hypothesis is put forward according to which its predecessor was the development. The latter secured maintenance of the organism? Energy balance in deteriorating environment at the early evolution stages.
Destruction of vitally important organs in primitive Invertebrates ensures asexual reproduction and adaptation to the environment deterioration. In course of morphophysiological progress reversibility of destructive processes was lost and their meaning has changed. One of them began perhaps to cause death from old age.
In sponges, coelenterates, bryozoans, and ascidians, blastogenesis associated with the formation of resting buds and resting blastogenetic structures is similar to the oncogenesis. Just as the tumours, such buds and structures: 1) when released from control of the parent organism, developed independently of the latter and cause its destruction; 2) originate due to the action of various external and internal causes; 3) are hardy to anoxia, dehydration, overcooling; 4) consist of little differentiated and de-differentiated cells. These similarities can be explained in the frame of hypothesis which considers tumours an atavistic resting structure.
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