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A V Myl'nikov

Publications and source records attributed to A V Myl'nikov.

5 recordsLinked to original sources
PubMed1980

[Experimental study of a new method of endolymphatic antibiotic administration and a trial of its clinical use].

A new procedure for antibiotic administration via endolymphatic route was developed. Experiments performed on 34 dogs revealed differences in the pharmacokinetics of gentamicin in the central lymph after its administration in a dose of 4 mg/kg via endolymphatic and intramuscular routes: the maximum levels of 590 and 23 mg/kg were determined in 15 and 45 minutes respectively. In 1 hour the concentrations decreased to 17 and 10 mg/kg. When gentamicin was administered endolymphatically it remained in the lymph and blood in concentrations of 0.2 and 0.8 mg/kg respectively for 24 hours. The kinetics of gentamicin in the blood serum within the first 6 hours after its administration by both routes did not differ significantly. After endolymphatic administration high concentrations of gentamicin (56-36 mg/g) were determined in the paraaortal and retroperitoneal lymph nodes in 10-24 hours. Within the period of the 4th to the 13th day its concentrations of at least 5 mg/g were detected. The changes in the structure of the lymph nodes observed 18-48 hours after the antibiotic endolymphatic administration were reversible and returned to normal by the 96th hour. The first experience with the clinical use of the endolymphatic route of gentamicin administration showed its high efficacy in 84.8% of the patients with severe purulent inflammatory diseases of the organs of the abdominal cavity. The antibiotic was used in a dose of 80 mg once a day. The treatment course consisted of 5-6 infusions. Perspectives of the further experimental and clinical investigation of the procedure are indicated. Endolymphatic administration of antibiotics makes it possible to increase the efficacy of antibiotic therapy of a number of severe inflammatory infections.

Adult↗
PubMedDate not supplied

[Characteristics of the pain sensitivity in patients with accompanying allergic diseases prior to stomatologic surgery].

The studies were performed on 161 patients with allergosis, aged 18 to 60 years. The severity of allergosis was the most significant clinical sign affecting the pain sensitivity of the patients under study. All the patients with allergoses were characterized by a higher psychoemotional response to pain stimuli than patients without the accompanying pathology. The patients with severe clinical signs of allergosis in history were characterized by hyperalgesia, while those with moderate allergosis were characterized by hypoalgesia. In patients with severe allergosis afferent signals processing in the central nervous system was disturbed. The differences in pain sensitivity in two groups of patients suggest different approaches to the selection of analgesia technique.

Adult↗