PubMed Health⌕ Search

Biomedical subjects

A V Nekrasov

Publications and source records attributed to A V Nekrasov.

At least 19 recordsLinked to original sources
PubMed2002

[Use of conjugated allergen-polymer vaccines (pollen allergens of new generation) for allergen-specific immunotherapy].

AIM: To assess effectiveness of new pollen allergotropins for allergen-specific immunotherapy (ASI). MATERIAL AND METHODS: The allergotropins were produced basing on conjugation of pollen allergoids (timothy, birch, mugwort pollen) and polyelectrolite (polyoxidonium) with immunomodulating properties. Pollen allergotropins (timpol, berpol) were designed to treat pollenosis caused by sensitization to timothy and birch pollen. Pollen allergotropins were studied in ASI given to 140 patients with pollenosis and 10 patients with bronchial asthma. RESULTS: In the group of pollenosis patients with hypersensitivity to birch pollen the response to berpol was excellent in 55% patients (the disease symptoms disappeared, antihistamine drugs intake was stopped), good--in 33%, satisfactory--in 12%. Timpol produced a marked response in all the patients treated for hypersensitivity to timothy pollen. CONCLUSION: Pollen allergotropins have a high therapeutic effect under low risk of provoking reactions of anaphylactic type in patients on ASI.

Adult↗
PubMed1997

[Use of immunomodulator polyoxydony in treatment and prevention of septic conditions in surgical patients].

52 patients (group 1) with a high risk of postoperative infective and septic complications and 58 surgical patients (group 2) with the developed infective septic complications are analysed. In 32 patients of group 1 and in 37 patients of group 2 immunomodulator Polyoxydony was used. The use of Polyoxydony in patients of both groups contributed to favourable dynamics of immune status, decrease of the rate of complications and postoperative mortality. Polyoxydony is effective medicine in prevention and treatment of postoperative infective and septic complications.

Adjuvants, Immunologic↗
PubMed1996

[Study of immunobiological properties of specific immunomodulators of the adjuvant type in experimental tuberculosis].

CBA mice served as experimental tuberculosis model to study protective, immunomodulating and toxico-allergic properties of two drugs including cytoplasma and cell walls of BCG mycobacteria as well as of synthetic adjuvant polyoxidonium. Doses and schemes are presented developed for experimental tuberculosis treatment with cytoplasm and not causing toxico-allergic reactions in mice. The specific immunomodulator of cytoplasm, polyoxidonium, proved effective therapeutic modality in experimental mouse tuberculosis.

Adjuvants, Immunologic↗
PubMed1992

[The current problems of relaparotomy].

Relaparotomy was performed in 252 of 23,232 (1.08%) patients operated upon. The most frequent cause of relaparotomy is purulent complications. These patients have immunodeficient states due to different causes (duration of the disease, old age, diabetes mellitus, toxemia, anemia, extension of the injuries, irrational administration of antibiotics). Due to it, anaerobic neclostridial infection is widely used. Its participation in the purulent process in the abdominal cavity achieves 80-90%. For prevention and treatment of purulent complications of great importance is the modern and adequate struggle against intoxication and hypoxia, correction of immunodepression, purposeful antimicrobial therapy. Problems in determination of indications for relaparotomy are emphasized and the necessity to perform it in earlier terms.

Adult↗
PubMed1991

[Antibodies to the rhamnose determinants of the polysaccharide of streptococci group A in the sera of rheumatism patients and donors].

In the sera of patients with recurrent rheumocarditis, and especially in cases of primary rheumatism, the level of antibodies to group A streptococcal polysaccharide (A-PS) has been found, according to the results of the enzyme immunoassay, to be considerably higher than in the sera of healthy donors. The level of antibodies to rhamnose determinants (RD) of A-PS has been determined by the inhibition of the immunoenzyme reaction with A-PS under the influence of a variant of group A streptococcus and rhamnose disaccharides with the bonds alpha 1-2 and alpha 1-3. In patients with recurrent rheumocarditis the level of antibodies to A-PS has been shown to be considerably higher than in healthy donors having these antibodies. In acute primary rheumatism a high level of antibodies to A-PS has been detected only in a few cases, and at the same time the prevalence of antibodies to the specific RD of A-PS, bound with beta-N-acetylglucosamine, is observed. In the sera of patients with recurrent rheumocarditis and donors having a high content of antibodies to the rhamnose site of A-PS antibodies, seemingly active against at least two RD, have been detected. In acute primary rheumatism an insignificant amount of antibodies to the rhamnose site of A-PS may probably cause the autoimmune process accompanying rheumatism. This suggestion is substantiated by the previously established capacity of these antibodies for inducing the suppression of cytotoxic cell reactions to microbial antigens.

Acute Disease↗
PubMed1991

[The enhancement of the immunogenicity of streptococcal group-A M protein by conjugation with a synthetic polyelectrolyte].

Immunization with the polypeptide fragment of group A streptococcal protein M conjugated with the copolymer of acrylic acid and N-vinylpyrrolidone in complete Freund's adjuvant has been found to lead to a sharp increase in the level of antibodies to the type-specific determinants of protein M, detected in the enzyme immunoassay (EIA). The possibility of the application of such sera to preliminary typing of streptococci in EIA with the use of whole microbial cells as antigens has been shown. The data on high activity of the sera thus obtained in the bactericidal test with streptococci of the homologous type are presented. Recommendations on the use of sera obtained by the above method for highly precise typing of the virulent cultures of group A streptococci in the bactericidal test are given.

Acrylic Resins↗
PubMed1991

[Level of antibodies to different determinants of Streptococcus group A polysaccharide and autoantibodies to basal layer of the skin epithelium in rheumatism].

Direct dependence was established between the presence of autoantibodies reacting with the basal layer of the skin epithelium (BLSE) and the high level of antibodies to the streptococcal group A polysaccharide (APS). By the primary active rheumatic fever (PARF) autoantibodies to the BLSE are revealed. By the recurrent active rheumatic fever (RARF) and in the control sera, autoantibodies reacting with the BLES, apparently, are directed to the rhamnose determinants of APS. These data confirm: different level of antibodies to the GS and to the rhamnose determinants of APS by PARF, RARF and in the control sera; the experiments of the autoantibody inhibition, reacting with the BLSE by the APS or the polysaccharide of streptococci A-variant, containing only the rhamnose determinants.

Adolescent↗
PubMed1989

[Actual problems of the treatment of lactation mastitis].

The article describes the experience with the treatment of 886 patients with lactation mastitis. For limited purulent foci preference is given to the dissection or wide opening of the abscess with wound dialysis and putting primary sutures. In patients with mastitis and symptoms of anaerobic damage wide openings (beyond the limits of the tissue involved) with necrectomy and following aeration of the wound are recommended; after complete cleansing the wound secondary sutures are possible or plastic closure of the wound. Complex conservative treatment after operation must be combined with the application of trichopol and its derivatives, oxygentherapy.

Abscess↗
PubMed1988

[Immunogenic activity of synthetic brucellosis antigens].

Experimental data obtained in this investigation indicate that the conjugation of Brucella protective antigen with a polymer carrier essentially increase the immunogenic properties of the antigen. Synthesized vaccinal preparations can be of interest for practical use, as these preparations, while inducing the development of intense immunity, do not impede the diagnosis of brucellosis by serological reactions. The comparative study of the conjugates of Brucella antigen with different carriers shows that the conjugated preparation obtained on the basis of modified dextran possesses high protective potency, which makes it possible to regard this carrier as very promising for further use.

Animals↗
PubMed1987

[Antibodies reacting with thymus and skin epithelium and antibodies to cell nuclei in immunization with streptococcal group A polysaccharide conjugated with synthetic polyelectrolytes].

The antibodies to streptococcal group A polysaccharide (A-PS) have been obtained upon immunization of BALB/c mice with A-PS conjugated with synthetic polyelectrolytes (PEL). Prolonged immunization in the majority of cases revealed antibodies to cross-reactive determinant of A-PS reacting with human and mouse epithelium of the thymus and basal skin layer. These antibodies belong to autoantibodies. Later on, after the beginning of immunization some animals produced antibodies reacting with cellular nuclei. The formation of autoantibodies to nuclei is not related to crossreactions with A-PS, because A-PS do not inhibit these reactions. No antibodies reacting with the epithelial cells or with cellular nuclei have been observed upon immunization with A-PS in Freund adjuvant or with PEL alone. The production of autoantibodies to cellular nuclei is probably a result of immunoregulatory disorders associated with the damage of thymus epithelium by autoantibodies during immunization with A-PS conjugated with PEL.

Acrylic Resins↗
PubMed1987

[Monoclonal antibodies against group A streptococcal polysaccharide reacting with basal-cell antigen of tumors histogenetically related to epidermal tissues].

Immunofluorescence of tumour tissues histogenetically related to tissues containing cross-reacting squamous epithelial basal-cell antigen (BCAg) was performed using monoclonal antibodies (McAb) A6/I-D to squamous epithelial basal-cell antigen cross-reacting with group A staphylococcal polysaccharide. BCAg was found in tumour cells arising from surface tissues of the epidermal type (basal-cell cancer, squamous-cell cancer of the skin, esophagus, cervix uteri and other organs) and was not found in glandular tumours (adenocarcinoma of the stomach, intestine, mammary glands). The results obtained indicate that McAb A6/I-D against cross-reacting BCAg may be used while characterizing the majority of normal epidermal tissues and tumours arising from tissues containing cross-reacting BCAg.

Antibodies, Monoclonal↗