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Biomedical subjects

A V Novikova

Publications and source records attributed to A V Novikova.

45 records · Page 3Linked to original sources
PubMedDate not supplied

[Clinico-morphological analysis of the results of endobronchial use of helium-neon laser in the treatment of chronic pneumonia in children].

In treatment of children with chronic pneumonia by 3-5 bronchoscopic cleansing procedures with endobronchial irradiation of the mucosa with a helium-neon laser beam the highest effect is produced by a dose of 15 mWt/cm2 and 2 minute exposure. Regression is stabler and occurs more rapidly in patients with moderate deformity of the bronchial tree. The mechanisms of the therapeutic effect of the method is explained by normalization of microcirculation, intensification of epithelial proliferation and biosynthetic activity which create favorable conditions for induction of reparative processes in the bronchial mucosa.

Adolescent↗
PubMedDate not supplied

[Pathomorphology of the large intestinal mucosa in acute infectious colitis].

634 biopsies of distal colon mucosa from 393 patients with acute intestinal bacterial and viral infections were studied histologically, histochemically and morphometrically. Acute catarrhal or catarrhal-hemorrhagic inflammation was found regardless of the colitis etiology (Shigella, Salmonella, Campylobacter, rotavirus). The most pronounced inflammation was in shigellosis and minimal one in rotavirus infection. Marked eosinophilic infiltration of the epithelium and tunica propria was observed in colonic contamination with C. pylori. Correlation analysis between morphometric indices in shigellosis and salmonellosis revealed a decrease in the number of strong functional links and the appearance of new ones indicating morphofunctional derangement.

Acute Disease↗
PubMedDate not supplied

[Viral antigens in kidney biopsies of children with glomerulonephritis].

A relationship between clinical forms of glomerulonephritis and incidence of viral antigens in renal tissue was revealed: Hepatitis B virus antigens (HBsAg) are more frequently detected in the glomeruli in the patients with nephrotic glomerulonephritis, Herpes simplex antigens are detected in the glomeruli in mixed glomerulonephritis, and cytomegaloviral and Herpes simplex antigens are detected in the epithelium of the proximal canaliculi in patients with hematuric glomerulonephritis. No correlations between the persistence of Herpes simplex type 1, cytomegalovirus, and HBsAg in the renal tissue were detected. HBsAg is detected in the renal tissue mainly in the children without free HBsAg in the blood serum. This may be indicative of an important role of specific immune complexes in the pathogenesis of glomerulonephritis associated with hepatitis B viral infection. The results point to an appreciable contribution of a persistent viral infection to the progress of glomerulonephritis.

Antigens, Viral↗
PubMedDate not supplied

[The age-related characteristics of the immune reaction of the mucosa of the gastric antrum in chronic gastritis].

Stomach biopsies from 16 adult patients at the age from 18 to 55 years, 16 adults of 56-68 years and 23 children were studied histologically, immunohistochemically and morphometrically. The frequency of Helicobacter pylori findings was dependent on the age. Local production of IgM and IgG was higher in the adults of young and mature age. Number of IgA producing cells decreased and that of IgG producing cells sharply increased in the aged persons; in this category also was increased the number of intraepithelial lymphocytes and of T-lymphocytes relating to the subpopulation of suppressor cytotoxic cells.

Adolescent↗
PubMedDate not supplied

[The persistence of Shigella sonnei in epithelial tissue in Serény's model].

The duration of persistence of S. sonnei in the tissues of a guinea pig eye (Serény's model) has been studied. Bacteriological and histological investigations made with the use of fluorescent antibody techniques have revealed that S. sonnei can be preserved in macrophages (histiocytes) and intercellular space of the eye epithelium for a long time (up to 277 days). The injection of ACTH or Shigella vaccine into the animals may provoke the exacerbation of the infectious process and the release of the infective agent.

Acute Disease↗
PubMedDate not supplied

[Morphometrics and immunohistochemical characteristics of chronic gastroduodenitis in adolescents].

Mucous membrane of the antral region of the stomach and that of duodenum were studied in 36 teenagers, 21 of them had erosions revealed endoscopically and histologically. Morphometric indices of the inflammation were more pronounced when erosions were present; the latter did not influence the local production of IgA, IgM and IgG. The content of IgG was particularly high. Contamination with Helicobacter pylori was found in all cases and was more pronounced in erosive gastroduodenitis. High frequency of lymphoid follicles formation was found, particularly in the antrum.

Adolescent↗
PubMedDate not supplied

[Age-related features of inflammatory and immune responses of the gastric mucosa in women with chronic gastritis].

The paper presents the results of studies of the specific features of an inflammatory reaction of the mucosa in the gastric body and antrum in chronic gastritis associated with Helicobacter pylori (HP) in females of reproductive age and in menopause. In the gastric body, there were prevalent chronic inflammatory processes with developed mononuclear infiltration in reproductive females whereas there were predominant elements of exudative and destructive inflammation in older females. The antral mucosa of young females showed predominantly destructive changes. The magnitude of HP seeding in the superficial and fossular mucosa was much higher both in the fundum and antrum in menopausal than reproductive females. There was great differences in the nature of inflammatory and immune reactions in either females with HP-associated chronic gastritis.

Aging↗
PubMedDate not supplied

[The immunomorphology of the mucosa of the bronchi and gastroduodenal zone in children with combined disease of the bronchi and gastrointestinal tract].

Mucous membrane of the bronchi, antral zone of the stomach and duodenum were studied histologically, morphometrically, immunohistochemically and bacterioscopically in 47 children of 5 to 14 years of age with bronchial asthma (16 patients), obstructive bronchitis (12 patients), chronic pneumonia or chronic nonspecific bronchitis (19 patients). All these children had also gastroduodenitis. There was an increase of local production of IgE and enhanced degranulation of mast cells in bronchial mucosa and gastroduodenal zone in children with bronchial asthma and obstructive bronchitis. The proportion of CD4+/CD8+ decreased to 0.92 in bronchial asthma. Gastritis was associated much more frequently with Helicobacter pylori in children with chronic obstructive bronchitis and bronchial asthma.

Adolescent↗