Biomedical subjects

A V Paranich

Publications and source records attributed to A V Paranich.

43 records · Page 3Linked to original sources

PubMedDate not supplied

[Protective effect of vitamin E in total ischemia of isolated organs in rats].

The content of lipid peroxidation (LPO) products and fat-soluble vitamins in the isolated liver and heart of rats total ischemia of organs has been studied. Ischemia shifts the antioxidative balance towards LPO and formation of vitamin E metabolites of different destruction degree. It is shown that under such conditions the reactions of initial tocopherol reduction are possible in the case of preliminary introduction of physiological doses of vitamin E into the organism. In the myocardium the protective effect of tocopherol is much higher than in the liver.

Animals↗

PubMedDate not supplied

[Comparison of the effectiveness of oil and water solutions of alpha-tocopherol as radiation protection agent].

The change in alpha-tocopherol content (as an index of the antioxidative organism system mobilization) in the brain, liver, muscles and heart of rats prior to and after total gamma-irradiation with lethal dose has been studied. Prior to the irradiation alpha-tocopheryl-acetate (oil solution), alpha-tocopheryl-phosphate dipotassium salt (water solution), gammaphos (prepared WR 2721, water solution) were introduced into rats. It is shown that water-soluble form of vitamin E is more effective than gammaphos and much more efficient than oil form of alpha-tocopherol.

Amifostine↗

PubMedDate not supplied

[Effectiveness of various pharmaceutical forms of alfa-tocopherol].

The content of alpha-tocopherol in brain, liver, heart and muscle of Wistar rats has been studied. The water-soluble form of alpha-tocopherol: alpha-tocopheryl-phosphate dipotassium is more effective than the oil-soluble form: alpha-tocopheryl-acetate.

Animals↗

PubMedDate not supplied

[The effect of alimentary vitamin E on the seasonal fluctuations in the level of fluorescent lipopigments in the tissues of irradiated rats].

In seasonal experiments (spring and autumn) with Wistar female rats, a study was made of the level of lipopigments (LP) and alpha-tocopherol (TPh) fluorescence in the liver and brain. Seasonal peculiarities of the parameters under study and their dependence on Vitamin E ingestion have been revealed. After irradiation of animals, an intimate morphofunctional relationship between LP and TP and its sensitivity to alimentary factors have been found. One hour following irradiation, part of LP is disintegrated thus releasing the TPh reserve. This may be the part of the complex of adaptation changes on the postirradiation metabolic effects.

Animals↗

PubMedDate not supplied

[Effect of weak SHF radiation on the level of fat soluble vitamins A and E in rat tissues].

The effect of SHF radiation on the content of A and E vitamins in tissues of rat brain, liver and testis was studied. Among the tissues examined, the brain was found to be most sensitive to weak SHF radiation. The radiation induced a change in the ratio of A and E vitamins in the brain, which, in turn, increased the probability of damage to cell membranes. In the liver, the tocopherol level after irradiation remained unchanged, and in the testis it increased insignificantly. This suggests a high resistance of the antioxidant systems of liver and testis tissues.

Adipose Tissue↗

PubMedDate not supplied

[The antioxidative activity of the tissues and lipids in rats of different ages].

The experiment on white Wistar rats 3-, 12- and 24 months old was carried out to study antioxidative activity in homogenates of the pancreas, adrenal glands, testes, muscles, heart and in lipids isolated from these tissues. The data were obtained in the model of thermal autooxidation of homogenates and lipids as well as during autooxidation of linethol in the presence of the samples studied. kinetics of peroxidation of tissue lipids, their effect on linethol oxidation rate and content of total lipids in the tissues were estimated. Contribution of the lipids to the total antioxidative activity of the tissue varies with age. Tissue properties of the parameters in question are observed as well as active participation of all the tissues studied in the support of the antioxidative homeostasis in the organism. Intensity of the participation depended on the age of animals.

Aging↗

PubMedDate not supplied

[The trends and intensity of lipid peroxidation processes initiated by the action of "Chernobyl" factors].

The 45-day's action of nutritional radionuclides (137Cs, 90Sr, 40K) by inside organism irradiation at doses: 0.16 sGy, 0.55 cGy, 5.5 cGy was investigated. The blood, muscles, heart, kidneys, lung, liver, brain, spleen and testis were studied. The content of dienes, trienes, oxodienes, tetraenes conjugates and malondialdehyde were researched. The level of dienes increased in blood and kidneys; MDA--in spleen than more, that more of dose irradiation. Content of oxodienes, trienes and tetraenes (the biological activity eicosanoids) decreased at kidneys, lung, brain and spleen. At total, these parameters by organism's adaptational systems controlled at physiological conditions.

Animals↗