[Mechanism of participation of vitamin PP and its nucleotide derivatives in neuromuscular transmission in smooth muscle].
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A V Romanenko
Publications and source records attributed to A V Romanenko.
[Vitamin PP, nicotinamide nucleotides and neuro-muscular transmission in guinea pig cecum longitudinal muscle (taenia coli)].
The membrane potential, inhibition postsynaptic potentials, resistance of the guinea pig taenia coli membrane were studied as affected by exogenic vitamin PP and its derivatives of nucleotide nature. It is shown that nicotinic acid, nicotinamide, NAD+, NADH, NADP+, NADPH evoke the membrane hyperpolarization and a decrease in the amplitude of the inhibition postsynaptic potentials. Nicotinamid dinucleotides cause a decrease in the membrane resistance, whereas nicotinic acid and nicotinamide do not affect this parameter. The character of the observed effects does not depend on the degree of nicotinamide dinucleotides oxidation.
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[Mechanism of action of vitamin B1, thiamine pyrophosphate, and FAD on smooth muscle cells].
The contractile activity of the guinea pig taenia coli longitudinal muscle was studied as affected by exogenic thiamine, thiamine pyrophosphate and FAD. The mentioned substances in a concentration of 1 . 10(-3) M relax the smooth-muscular cells. Against a background of apamine FAD causes a contraction of taenia coli, which is not observed with application of thiaminepyrophosphate. Evidently, there are two, types of receptors sensitive to FAD and one sensitive to vitamin B1 on the membrane of the smooth-muscular cell.
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