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Biomedical subjects

A V Shpektor

Publications and source records attributed to A V Shpektor.

12 recordsLinked to original sources
PubMed2004

[The Use of Clopidogrel in Conjunction With Thrombolytic Therapy in PatientsWith ST-Elevation Acute Myocardial Infarction.].

Clopidogrel (300 mg before initiation of thrombolysis and 75 mg/day thereafter) was given to 46 of 131 patients with streptokinase treated ST-elevation acute myocardial infarction. Mortality and efficacy of thrombolysis were similar in 2 groups, however deaths of acute heart failure were distributed unevenly (0 in clopidogrel group and 8 or 9.4% among other patients, p <0.03). Clopidogrel treated compared with other patients had significantly higher left ventricular ejection fraction on days 1-2 of disease (52.5+/-2.2 and 45.9+/-2.0%, respectively, p<0.03). Number of bleedings did not differ significantly between 2 groups. Thus patients addition of clopidogrel to aspirin and thrombolysis with streptokinase was associated with better myocardial contractile function and lower mortality due to acute heart failure.

Aspirin↗
PubMed1991

[Treatment of ventricular arrhythmia resistant to sodium channel blockaders].

The efficacy of antiarrhythmic agents of various groups (Na(+)- and Ca(2+)-channel blockers, cordarone) was comparatively evaluated in the same patients with ventricular arrhythmias. Cordarone and Na(+)-channel blockers were equally effective, whereas verapamil was significantly less potent. Then the antiarrhythmic efficacy of verapamil and cordarone was assessed individually in rhythm disturbances responsive to Na(+)-channel blockers and resistent to their action. The efficacy of verapamil was significantly higher in patients resistant to Na+ blockers than in those responsive to them. The action of cordarone was equal in these two groups of patients, however, it occasionally abolished arrhythmias resistant to both Na(+)- and Ca(+)-current blockers. The findings suggest the pattern of choosing antiarrhythmic therapy in ventricular arrhythmias.

Adult↗
PubMed1990

[Relations between the duration of coupling interval and frequency fluctuations in ventricular ectopic complexes].

An attempt was made to electrocardiographically assess the likely mechanisms responsible for the occurrence of arrhythmias. The frequency of ventricular ectopic complexes was compared with fluctuations of coupling interval duration. An examination of 36 patients provided evidence for preliminary considerations concerning the causation between the frequency of ventricular ectopic complexes and the duration of coupling interval. The findings are promising from clinical and predictive points of view.

Adolescent↗
PubMed1990

[Characteristics of disorders of hemostasis and lipid metabolism in patients with different pathogenetic forms of angina pectoris].

The likely mechanisms responsible for the occurrence of angina pectoris, which were revealed by 24-hour ECG monitoring, were correlated with abnormalities in hemostasis and blood lipid spectrum. Changes in the blood lipid spectrum were demonstrated to play the leading role in the development of angina due to higher myocardial oxygen demand. Those in platelet hemostasis are mostly pronounced in impaired myocardial oxygen supply due to vessel spasm and/or formation of platelet aggregates.

Adult↗
PubMed1986

[Contrast echocardiography using hydrogen peroxide].

The practicability of using hydrogen peroxide solutions for contrast echocardiography was examined. The administration of 1-3 ml of 0.2% solution mixed with a drop of the patient's blood, into the cubital or catheterized subclavian vein produced intensive and lasting (up to 2 min) contrast of the right cavities of the heart. Cubital injection of the solution was associated with a more lasting effect, as compared to the subclavian administration. The causes of this difference are yet to be investigated. The contrasting effect was fairly persistent and marked even when concentrations of the hydrogen peroxide solutions were reduced to 0.15 or 0.1%. The rate of administration was not more than 1 ml/s and had no negative effect on the quality of the contrast. No side effects associated with repeated administration of 1-3 ml hydrogen peroxide solution in the above-mentioned concentrations were noted in either of the 20 patients thus examined.

Contrast Media↗