Biomedical subjects

A V Slavutskaia

Publications and source records attributed to A V Slavutskaia.

3 recordsLinked to original sources

PubMed2005

[Decrease of nitric oxide (NO)-cGMP-dependent vasodilatation in the vessels of lesser circulation in endothelial dysfunction].

Inducible NO-synthase inhibitor aminoguanidine (AG) was used for investigation into enhanced nitric oxide (NO) production influence on elevated pressure in the pulmonary circulation (pulmonary hypertension, PH) under endothelial dysfunction. PH was simulated by subcutaneous injection of 60 mg/kg MCT to Wistar rats. Experimental groups were given AG in drinking water (15 mg/(kg x day)), and control groups were given drinking water. Rate of nitrite/nitrate excretion (RENOx) with urine was measured. The RENOx was elevated since second week as long as through the PH development. Chronic AG administration led to RENOx and soluble guanylate cyclase (sGC) NO-dependent activity restoration, and also it led to partial restoration of the right ventricular pressure. AG administration restored the perfusion pressure responses of isolated pulmonary arteries to acetylcholine. These results suggest that chronic inducible NO-synthase inhibition restores the impaired endothelium-dependent and sGC-dependent relaxation of pulmonary artery in MC-induced PH.

Animals↗

PubMedDate not supplied

[Role of filtration in localization of the evoked potential dipoles in the human brain: experiment and simulation].

3D dipole tracing with 1 ms step of visual evoked potentials recorded from 40 electrodes was performed under exposition of crosses in 5 healthy human subjects. The data on dipole displacement were compared with prediction of the simulation study on distortion of dipole localization by the signal filtration in the low-frequency band. These predictions were experimentally confirmed: the effect depends on the degree of filtration (0.1 or 0.5 Hz) and on the latency of EP waves. Localization and strength of P1 dipoles were not changed under filtration, while for later components--N2 and especially P3--they changed significantly. For the improvement of these distortions time constant of the amplification tract must be some times longer than the time of the dipole activity.

Brain↗

PubMedDate not supplied

[Human visual evoked potentials to bars and cross-like figures].

Temporal and amplitude characteristics of averaged visual evoked potentials to presentation of lines, corners and crosses with different orientation recorded in 19 adult healthy subjects were compared in 34 derivations. In all subjects, the latencies of P1, N2, and P3 were shorter while their amplitudes were higher for crosses than for lines. The effect of lengthening of P1 peak latency from occipital to temporal cortex was mostly pronounced for EPs to a bar, whereas as increase in the P1 amplitude was most evident for a cross-like figure. Correlation of these data with: i) greater magnitude and shorter latencies of responses to crosses vs. bars in a half of cat striate neurons, ii) sensitivity of cells in monkey inferior temporal cortex to star-like figures, and iii) relatively better human recognition of figures with comers than with lines, as well as significance of the effects obtained for detection of image features in different areas of the human visual cortex is discussed.

Adult↗