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A V Spirov

Publications and source records attributed to A V Spirov.

5 recordsLinked to original sources
PubMed2000

HOX Pro: a specialized database for clusters and networks of homeobox genes.

It is now clear that the homeobox motif is well conserved across metazoan phyla. It has been established experimentally that a subset of genes containing this motif plays key roles in the orchestration of gene expression during development. Auto- and cross-regulatory functional interactions join homeobox genes into genetic networks. We have developed a specialized database HOX-Pro in order to arrange all available data on structure, function, phylogeny and evolution of Hox genes, Hox clusters and Hox networks. Its primary location is http://www.iephb.nw.ru/hoxpro. The database is also mirrored at http://www.mssm.edu/molbio/hoxpro. The HOX-Pro database is aimed at: (i) analysis and classification of regulatory and coding regions in diverse homeobox and related genes; (ii) comparative analysis of organization of 'Hox-based' genetic networks in the sea urchin Strongylocentrotus purpuratus, the fruit fly Drosophila melanogaster and the mouse Mus musculus; and (iii) analysis of phylogeny and evolution of homeobox genes and clusters.

Animals↗
PubMed1998

Graphical interface to the genetic network database GeNet.

UNLABELLED: We designed a Java applet which enables the visualization of genetic networks and can be used as a Web publishing tool by molecular biologists studying the mechanisms of gene interactions. AVAILABILITY: http://www. csa.ru/Inst/gorb_dep/inbios/ genet/Graph/Genes_Graph.html CONTACT: samson@fn.csa.ru

Computational Biology↗
PubMedDate not supplied

[The pattern of the expression of homeo box-containing genes in the mesenchyme of the mammalian limb bud as a coordinate network for subsequent morphogenetic processes].

Hypothesis is developed about mechanisms of determination of limb bud of mammals as a result of expression of homeo box containing genes (hox genes) of known up to date four hox families. Spatial pattern of the expression plays a role of coordinate system for subsequent processes of morphogenesis and differentiation of the limbs. Propositions of the hypothesis are realized in a computer dynamic model. The results of modeling are compared with known data on features of the expression of hox genes in the mesenchyme of developing limb buds in mammals and birds.

Animals↗
PubMedDate not supplied

[The role of conserved sequences in the regulatory elements of the Antp-like homeobox-containing genes of vertebrates].

By the present time the homeobox genes have been found in the representatives of the main invertebrate and vertebrate taxa. It has been demonstrated that these genes play the key role in the space and time genome expression orchestration in ontogenesis. The autoregulatory and cross-regulatory functional interactions integrate the homeobox genes into the gene networks. We found a correlation in variability of the coding and regulatory regions for vertebrate homeobox genes. The phylogenetic relations of structure and regulatory elements involved into the cross- and autoregulatory connections have been investigated in detail. The comprehensive phylogenetic analysis of the promoter region for these genes compared to results of such analysis of their homeoboxes has revealed two opposed tendencies in evolution of the regulatory elements of genes. The first trend is conservation of many regulatory elements in evolution of vertebrate homeobox genes and the second one is high variability of other non-coding gene regions.

Amino Acid Sequence↗