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Biomedical subjects

A V Starikov

Publications and source records attributed to A V Starikov.

At least 19 recordsLinked to original sources
PubMed2006

Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation.

Tumour development is characterised by the increased circulating DNA (cirDNA) concentration and by tumour-related changes in blood plasma DNA. Concentration of cirDNA and methylation of RARbeta2, RASSF1A and HIC-1 gene promoters were investigated in cell-free and cell-surface-bound fractions from healthy donors, patients with breast cancer, and patients with breast fibroadenoma. Tumour development was shown to lead to significant changes in the distribution of cirDNA between cell-free and cell-surface-bound fractions. Analysis of RARbeta2 and RASSF1A methylation in the total cirDNA provides 95% diagnostic coverage in breast cancer patients, 60% in patients with benign lesions, and is without false-positive results in healthy women. Results of the study indicate that methylation-specific PCR of RARbeta2 and RASSF1A genes based on the total cirDNA combined with the quantitative analysis of cirDNA distribution between cell-bound and cell-free fractions in blood provide the sensitive and accurate detection and discrimination of malignant and benign breast tumours.

Breast Neoplasms↗
PubMed2005

Plasma content of extracellular nucleic acids in donors and patients with mammary tumors.

The concentrations of extracellular DNA and RNA were measured in the plasma of donors and patients with fibroadenoma and breast cancer. The content of extracellular DNA surpassed the normal in 80% plasma samples from patients with mammary tumors. Extracellular RNA was detected in 30% plasma samples from donors and patients with breast tumors. No correlations were found between plasma concentration of extracellular DNA and size and stage of tumor growth. Hence, measurement of extracellular DNA in the plasma of patients can be used only as an accessory test for tumor diagnosis.

Breast Neoplasms↗
PubMed2005

[Application of glass-crystalline granules of biosit-elcor for reducing the size of trepanation cavity in middle ear surgery].

The authors describe experience in application of bioglass preparations (biosit-elcor) for partial obliteration of mastoid cavities in open operations on the middle ear in 17 patients. Long-term results were studied with otomicroscopy and computed tomography of the temporal bones. A good morphological result of the operation (complete epithelization of the wound surface, no discharge from the ear) was achieved in all the patients. Computed tomography showed step-by-step osteointegration of the implant.

Adolescent↗
PubMed2004

[Application of plasmapheresis and perftoran in thoracic diseases].

In patients with purulent disease of thoracic cavity the discrete plasmapheresis and infusion-transfusional therapy, using perftoran emulsion, were applied in complex of treatment. The efficacy of application of oxygentransporting blood substitutes, based on perfluorohydrocarbons, for the plasmexfusion and in the treatment of respiratory hypoxia in patients was established.

Adult↗
PubMed1989

[Plasmapheresis in the complex treatment of acute pancreatitis].

After the performance of therapeutical plasmapheresis in the blood of the patients with acute pancreatitis, the concentrations of bilirubin, urea, creatinine++, the plasma toxicity decreased. The use of plasmapheresis in the complex of intensive therapy permits to reduce considerably endotoxemia, facilitates the effectiveness of treatment.

Acute Disease↗
PubMed1989

[Plasmapheresis in the intensive therapy of renal insufficiency].

Results of the treatment of 12 patients operated on organs of the abdominal cavity for peritonitis and 2 patients with purulent pyelonephritis are described. The patients had different degrees of disturbances of the renal function (renal insufficiency included). The use of plasmapheresis improved the diuretic function of the kidneys, parameters of glomerular filtration and reduced azotemia. However in patients with the terminal renal insufficiency the including of plasmapheresis and hemofiltration proved to be unsuccessful.

Adult↗
PubMed1987

[Blood transfusion and therapeutic plasmapheresis].

The authors used gravitation plasmapheresis in 153 patients with different diseases and developed and substantiated principles of correcting therapy based on the combination of different transfusion media. The use of transfusion maintenance in plasmapheresis results in considerably less side reactions and complications.

Blood Transfusion↗