PubMed Health⌕ Search

Biomedical subjects

A V Volodina

Publications and source records attributed to A V Volodina.

18 recordsLinked to original sources
PubMed2004

Structural and functional rearrangement of muscle spindles in rats under conditions or zero gravity.

Electron microscopy of muscle spindles in m. extensor halucis longus of rats 14 days after space mission on board SLS-2 space laboratory (USA) showed structural rearrangement in the receptors. The number of intrafusal fibers increased, but some fibers developed degenerative changes. The changes were also seen in the spindle capsule, but its integrity was not impaired. Vascularization of the spindle capsule was impaired as a result of necrobiotic changes in capillary endotheliocytes. Sensory nerve endings were the most sensitive structures of the receptor. Destructive changes in various structures of the muscle spindles were paralleled by regenerative processes.

Animals↗
PubMed1993

[Ultrastructural features of muscle spindle organization in a replanted limb].

It has been shown that in a month after replantation of extremity the muscle fibres survive. Some of them have got good safety, in others--destructive-degenerative changes prevail. The reinnervation processes were not perfect because of the disturbance of axon-Schwann interrelations and as a result of this--the presence of the degenerative forms of Schwann cells.

Animals↗
PubMed1991

[Analysis of the causes of incomplete structural and functional restoration of the skeletal muscles after severe traumatic injury to the limb (ultrastructural study)].

The work is concerned with light-optic and ultrastructural analysis of the causes of incomplete structural and functional restoration of skeletal muscles after extensive trauma and replantation of the limb. It was found that posttraumatic myogenesis was limited due to change of some of the satellite cells from the myogenic type of development to differentiation with the formation of fibroblast-like cells. In distinction from the embryonal cells, the myoblasts form the surrounding basal membranes earlier which prevents their fusion and the formation of the myosymplast. The features of the macrophageal reaction, its permanency lead to accumulation of collagen in the interstitium. Progressing secondary neurogenic atrophy develops at the tissue level. The developing posttraumatic microangiopathies are the cause of secondary destructive changes in the muscles. The disorders of tissue nutrition and the progressing atrophic and destructive-degenerative processes gear the autoimmune mechanisms in the late periods which is conducive to stable chronicity of the pathological process in the muscle.

Animals↗
PubMed1988

[Characteristics of post-traumatic differentiation of satellite cells in skeletal muscles].

Muscle trauma during preliminary denervation stimulates generation and differentiation of satellite cells. There are two types of posttraumatic cells with different types of albumin synthesis (intracellular and extracellular) under the sarcolemma of the muscle fibers. It is assumed that either two different types of cells differentiating along myogenic and fibrogenic lines are to be found under muscle sarcolemma, or the original satellite cell is capable of differentiating in several directions.

Albumins↗
PubMed1983

[Ultrastructural study of posttraumatic regeneration of muscle tissue in adult rats].

Regeneration of muscle fibers in pubertal rats (days 8 and 10 after mechanical trauma) can be followed until the occurrence of muscle tubules, resembling tissue formation during embryogenesis. Apart from the cellular type regeneration, the contractile apparatus recovery was also observed inside the preserved basal-sarcolemmal skirts according to the type of intracellular reparative regeneration.

Animals↗
PubMed1981

[Ultrastructural study of the early stages of skeletal muscle regeneration in sexually mature animals].

It has been found that during the crush of musculus gastrocnemius in adult rats, there occur two sources of myoblast formation: satellite cells and nucleo-sarcoplasmatic areas that split off injured muscle fibers. The latter process is preceded by changes in the ultrastructure of the perinuclear cytoplasmic zone where microtubules, ribosomes and polyribosomes, fissural cavities, vesicles, myofilaments, and cisterns of the rough endoplasmic reticulum are formed.

Animals↗
PubMed1976

[The vesicular system of the endothelium in the blood-carrying capillaries of the diaphragm with different functional states].

Micropinocytotic vesicles were counted in the endothelial cells of blood capillaries in the muscle of the diaphragm in its indirect rhythmic stimulation at a frequency of 50 imp/s after section of the phrenic nerve, and also in natural contraction and relaxation of the muscle during respiration. A change in the total count of the vesicles and even more pronounced changes in the ratio of the vesicles bound with plasmic membranes and freely located in the cytoplasm of the cells were revealed; this pointed to the change in the transendothelial transfer of substances. It appeared that the state of the process of vesicle formation could influence the method of fixation applied.

Animals↗
PubMedDate not supplied

[Features of the structural-functional organization of muscles of replanted rat limb].

The article characterizes the structural-functional organization of fast and slow muscles of replanted rat limb by methods of light-optic, ultrastructural, and morphometric analysis. The results of the study allowed a conclusion to be drawn that the initial organization of the muscles is not restored in the late terms after replantation. New structural-functional units form in them which differ from the initial system of functioning and vitality provision. Grounds for advancement of destructive-degenerative changes are laid down in the newly formed system of neuro-muscular and vascular-tissue relations. The possible vascular, neural, and autoimmune mechanisms of timing of the pathological process in the replant muscles are discussed.

Animals↗