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Biomedical subjects

A V Zhuravlev

Publications and source records attributed to A V Zhuravlev.

At least 19 recordsLinked to original sources
PubMed1995

[The dynamic importance of proteinuria and arterial pressure for detecting late toxicosis in pregnant women with chronic kidney diseases and hypertension].

Time course of 187 pregnancies was followed up in 103 females with chronic renal diseases (CRD), 76 females with essential hypertension (EH) and 14 posteclampsia females. Three variants of arterial pressure (AP) and 5 types of proteinuria changes were recognized in CRD and EH patients. The pattern of these changes was compared to that in posteclampsia patients, the eclampsia being an absolute criterium of late toxicosis. It is shown that neither elevated AP and proteinuria nor their absolute values can serve reliable signs of late gestosis in CRD and EH patients. Only the trend in these parameters is significant. CRD and EH females with late gestosis exhibit rapidly growing proteinuria in line with the onset or exacerbation of EH. Retrospective analysis of the pregnancies has confirmed association of late gestosis in 15% of EH and 7% of chronic glomerulonephritis patients. These estimates are lower than commonly accepted. Early diagnosis of late gestosis in pregnant females with CRD and EH requires not only regular AP registration, but also dynamic, in some cases hourly, evaluation of proteinuria.

Blood Pressure↗
PubMed1995

[The diagnostic characteristics of late toxicosis in pregnant women with hypertension and chronic kidney diseases].

A study was made of diagnostic significance (sensitivity and specificity) of early (precritical) signs of late gestosis (LG). A total of 179 females (187 pregnancies) with essential hypertension (EH) and chronic renal diseases (CRD) were examined. EH women are at high risk of LG when they have proteinuria above 0.3 g/s, of relative prognostic importance are severe hypertension and marked hyperuricemia. Severe hypertension, fetal growth inhibition, positive roll-over test may indicate LG in CRD. Primiparas with EH or CRD are especially at risk of LG. As all the above LG signs in its precritical stage are not specific and indicate only probability, they can be used primarily for screening of patients with high risk of LG onset. The diagnosis of LG in EH and CRD should be based on follow-up changes in the clinical and laboratory indices.

Chronic Disease↗
PubMed1990

[Cellular composition and T-lymphocyte subpopulations in the bronchoalveolar lavage fluid in patients with fibrosing alveolitis and pulmonary granulomatosis].

Cytological and immunological investigations of bronchoalveolar lavage fluid (BLF) have been performed in 87, 27, 32 and 94 patients with fibrosing alveolitis (FA), exogenous allergic alveolitis (EAA), histiocytosis and pulmonary sarcoidosis (PS), respectively. The diseases appeared to demonstrate significant differences in BLF cell composition and relations between T-lymphocyte theophyllin-resistent and theophyllin-sensitive subpopulations. The findings can be applied in differential diagnosis of disseminated processes in the lungs. The number of neutrophils and the subpopulations correlation in FA and EAA may serve criteria of the disease activity and adequacy of the treatment administered.

Alveolitis, Extrinsic Allergic↗
PubMed1988

[Diagnostic bronchoalveolar lavage in assessing the efficacy of the treatment of idiopathic fibrosing alveolitis].

A study of the results of repeated diagnostic bronchoalveolar lavage in 27 patients with idiopathic fibrosing alveolitis (IFA) has shown that the investigation of cellular composition of the bronchoalveolar content (BAC) made it possible to specify IFA activity and its therapy-related change. Normalization or a decrease below 6% of the neutrophil content in BAC was typical of achieving low activity and remission of disease. A relatively high count of neutrophils in BAC (over 10%) during therapy was observed in preserved significant IFA activity resistant to drug therapy.

Adult↗
PubMed1987

[Characteristics of the silver-stained nucleoli of tumor cells from the pleural fluid of lung cancer patients].

Tumor cell nucleoli obtained from pleural effusions of 26 patients with different morphologic types of lung cancer were evaluated by silver staining. Distinct heterogeneity of tumor cell populations, with regard to the number of nucleoli as well as their functional activity in respect to ribosomal RNA synthesis, were shown to be the most common feature of all the tumors studied, regardless of their morphologic variants. One likely cause of heterogeneity in Ag nucleolar organized region (NOR) pattern of tumor cells may be due to chromosomal losses and gains from the karyotypes of acrocentric chromosomes with active NORs. Another possible cause for heterogeneity in nucleolar activity might be due to different reactions of tumor cells towards some humoral and cellular factors of pleural fluid including T-lymphocytes.

Adult↗
PubMed1985

[Subsegmental bronchoalveolar lavage in the diagnosis of inflammatory and disseminated processes in the lungs].

Analysis of the results of the diagnostic bronchoalveolar lavage (BAL) in 108 patients has shown that based on the study of the cellular composition of the bronchoalveolar washing (BAW) one can form a judgment about the activity of chronic bronchitis and disseminated processes in the lungs. In individual patients, the cytological examination of the BAW permits detecting the characteristic cell elements (hemosiderophages, tumor cells) and verifying the pattern of the disseminated process in the lungs.

Adolescent↗
PubMed1984

[Absorption by rat fetal tissues of 14C-labeled phospholipids injected into the rat body in the late stages of pregnancy].

The authors studied the possibility of 14C-phospholipid transplacental penetration after 15C-phospholipid injection into rats at the 20th day of pregnancy. The preparation of 14C-phospholipids (total phospholipids) was isolated by thin-layer chromatography from the liver of rats injected with 2-14C-sodium acetate. One hour after its injection into the rat, 14C-phospholipids were detectable in total phospholipids of the pulmonary and cerebral fetal tissues. It was discovered that specific radioactivity of phospholipids contained by these tissues was 2--5 times higher when 14C-phospholipids were injected subcutaneously as compared with intramuscular injection. It is concluded that exogenous phospholipids entrapped in the mother's circulation penetrate the placental barrier of the fetus and the blood-brain barrier of the mature fetus, being consumed by different fetal tissues for forming membrane structures of the fetal tissues.

Animals↗